Gallic Acid, an Antioxidant, Exhibits Antiapoptotic Potential in Normal Human Lymphocytes: A Bcl-2 Independent Mechanism

Synthesis, Antimicrobial and Antitubercular Activities of Some Novel Trihydroxy Benzamido Azetidin-2-one Derivatives

“…Gallic acid is a naturally existing antioxidant [9] which occurs along with tannins in most plant species. It possesses various biological activities such as analgesic [10], antimicrobial [11], antineoplastic [12] and antityrosinase [13].…”

Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

“…The radical scavenging effect and inhibition of LPO have been reported as major activities of meGAL (Westenburg et al, 2000;Galato et al, 2001;Cho et al, 2003). In addition, meGAL possesses the biological activities including antiplatelet activity (Lim et al, 2004), protection of DNA damaging against oxidative stress (Hsieh et al, 2004), protection of lung injury induced by phosgene (Sciuto and Moran, 2001), attenuation of diabetic oxidative stress (Cho et al, 2004) and antiapoptotic activity (Sohi et al, 2003). However, radical scavenging ability of meGAL has been a main focus to explain its protective function against oxidative stress.…”

“…The persistent production of abnormally large amount of ROS or RNS, however, Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress may lead to persistent changes in signal transduction and gene expression, which in turn may give rise to certain diseases. meGAL is known as one of major antioxidants (Westenburg et al, 2000;Galato et al, 2001;Cho et al, 2003;Sohi et al, 2003). meGAL is a phytochemical from various species including Meliaceae, Rosa Rugosa and Galla Rhois, and its derivative (-)-epigallocatechin gallate (EGCG) is a major pytochemical of green tea, well known antioxidative beverage (Chen and Zhang, 2003).…”

In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

“…Gallic acid is a ubiquitous natural product with various industrial applications including ink dyes, tanning products, and paper (14). Recent studies have documented that gallic acid and its esters [e.g., (-)-epi-gallocatechin-3-gallate] exert antioxidant, anticancer, antiviral, and many other biological effects (15)(16)(17). The cytoprotective properties of gallic acid in vitro have also been observed previously (18,19).…”