Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Whang, Wan Kyunn; Park, Hyung Soon; Ham, In-Hye; Oh, Mihyun; Namkoong, Hong; Kim, Hyun Kee; Hwang, Dong Whi; Hur, Soo Young; Kim, Tae Eung; Park, Yong Gyu; Kim, Jae-Ryong; Kim, Jin Woo

doi:10.1038/emm.2005.44

Cited by 53 publications

(24 citation statements)

References 36 publications

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“…Our study provides an explanation for the functional redundancy of the sigma-1 receptor KO mouse. From our study as well as other published reports (Whang et al, 2005; Hayashi and Su, 2007; Yang et al, 2007; Smith et al, 2008), it is clear that the sigma-1 receptor has both antioxidative as well as chaperoning activities, which are sensitive to sigma-1 receptor ligands. Thus, it is expected that the sigma-1KO mouse would have higher levels of proteins and/or metabolites, which have either antioxidative or chaperoning activities in the cells.…”

Section: Discussionsupporting

confidence: 84%

“…Increased ligand binding activity to sigma-1 receptors in retinal Muller cells has been observed in vitro when the cells were treated with NO and reactive oxygen species donors (Jiang et al, 2006) and protection of human umbilical vein endothelial cells (HUVEC) from oxidative stress by the antioxidant methyl gallate, has been linked to up-regulation of the sigma-1 receptor gene (Whang et al, 2005). It has been also reported that sigma-1 receptor ligands can protect retinal cells against oxidative stress (Smith et al, 2008) and provide protection by increased transcription of antiapoptotic bcl-2 mRNA to preserve a favorable bcl-2/bax ratio in injured neurons (Yang et al, 2007) as well as in CHO cells via NFkappaB pathway (Meunier and Hayashi, 2010).…”

Section: Discussionmentioning

confidence: 99%

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The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

Pal

Fontanilla

Gopalakrishnan

et al. 2012

European Journal of Pharmacology

138

116

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Sigma-1 receptors are associated with Alzheimer's disease, major depressive disorders, and schizophrenia. These receptors show progrowth/antiapoptotic properties via their chaperoning functions to counteract ER (endoplasmic reticulum) stress, to block neurodegeneration, and to regulate neuritogenesis. The sigma-1 receptor knock out mouse offered an opportunity to assess possible mechanisms by which the Sigma-1 receptor modulates cellular oxidative stress. Nuclear magnetic resonance (NMR) metabolomic screening of the WT (wild type) and sigma-1 KO (knockout) livers was performed to investigate major changes in metabolites that are linked to oxidative stress. Significant changes in protein levels were also identified by two-dimensional (2D) gel electrophoresis and mass spectrometry. Increased levels of the antioxidant protein peroxiredoxin 6 (Prdx6), and the ER chaperone BiP (GRP78) compared to WT littermates were detected. Oxidative stress was measured in WT and sigma-1 KO mouse liver homogenates, in primary hepatocytes and in lung homogenates. Furthermore, sigma-1 receptor mediated activation of the antioxidant response element (ARE) to upregulate NAD(P)H quinone oxidoreductase 1 (NQO1) and superoxide dismutase 1 (SOD1) mRNA expression in COS cells was shown by RT PCR. These novel functions of the sigma-1 receptor were sensitive to well-known sigma ligands via their antagonist/agonist properties.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

Pal

Fontanilla

Gopalakrishnan

et al. 2012

European Journal of Pharmacology

138

116

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“…Many natural products including flavonoids, coumarins, polyols have been studied for the characterization and the development as antioxidative reagents (Finkel and Holbrook, 2000;Han, 2003;Whang et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress

Whang

Park²,

Ham³

et al. 2005

Exp Mol Med

Self Cite

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Coumarins comprise a group of natural phenolic compounds found in a variety of plant sources. In view of the established low toxicity, relative cheapness, presence in the diet and occurrence in various herbal remedies of coumarins, it appears prudent to evaluate their properties and applications further. The purpose of this study is to investigate cellular protective activity of coumarin compound, fraxin extracted from Weigela florida var. glabbra, under oxidative stress, to identify genes expressed differentially by fraxin and to compare antioxidative effect of fraxin with its structurally related chemicals. Of the coumarins, protective effects of fraxin against cytotoxicity induced by H2O2 were examined in human umbilical vein endothelial cells (HUVECs). Fraxin showed free radical scavenging effect at high concentration (0.5 mM) and cell protective effect against H2O2-mediated oxidative stress.

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“…have shown inhibitory actions on NF-κB related inflammatory responses. For instance, phytosterols present in Rosa spp., such as, β-sitosterol, attenuates the phosphorylation of NF-κB in TNF-α-stimulated human endothelial cells [115]. Phenolic compounds, such as gallic acid, re-establishes the association of IκBα with NF-κB, hampering the capacity of NF-κB to bind DNA [116], while astragalin and tormentic acid inhibit IkBα phosphorylation and degradation as well as NF-κB nuclear translocation [111,117].…”

Section: Rose Hip and Diseasementioning

confidence: 99%

Therapeutic Applications of Rose Hips from Different Rosa Species

Mármol

Sánchez-de-Diego

Jiménez-Moreno

et al. 2017

IJMS

127

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Rosa species, rose hips, are widespread wild plants that have been traditionally used as medicinal compounds for the treatment of a wide variety of diseases. The therapeutic potential of these plants is based on its antioxidant effects caused by or associated with its phytochemical composition, which includes ascorbic acid, phenolic compounds and healthy fatty acids among others. Over the last few years, medicinal interest in rose hips has increased as a consequence of recent research that has studied its potential application as a treatment for several diseases including skin disorders, hepatotoxicity, renal disturbances, diarrhoea, inflammatory disorders, arthritis, diabetes, hyperlipidaemia, obesity and cancer. In this review, the role of different species of Rosa in the prevention of treatment of various disorders related to oxidative stress, is examined, focusing on new therapeutic approaches from a molecular point of view.

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Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress

Abstract: Methyl gallate (meGAL) is known as one of major antioxidants. To investigate whether meGAL protects human cells from oxidative stress, meGAL extracted from Korean medicinal plant, Cercis chinensis leaves, was primarily screened using cell viability assay against oxidative stress.

Cited by 53 publications

References 36 publications

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements

Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress

Therapeutic Applications of Rose Hips from Different Rosa Species

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