Gallbladder Metastasis of Renal Cell Carcinoma

Sparwasser, C.; Krupienski, M.; Radomsky, J; Pust, R

doi:10.1159/000282998

Cited by 21 publications

(1 citation statement)

References 2 publications

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“…Metastases to the gall-bladder are very rare and and in most cases, the primary tumour is a malignant melanoma [1,2]. Renal cell carcinomas account for approximately 3% of all adult malignancies and have the potential to metastasise to almost any site in the body [3].…”

Section: Discussionmentioning

confidence: 99%

An unusual gall-bladder polyp - site of metastatic renal cell carcinoma: a case report

et al. 2009

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Section: Discussionmentioning

confidence: 99%

An unusual gall-bladder polyp - site of metastatic renal cell carcinoma: a case report

et al. 2009

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Metastases from Cancers of the Urogenital Tract

TxNxM1

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Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

Zimmermann¹

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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The gallbladder is involved by a wide variety of non-epithelial tumors, apart from mesenchymal neoplasms. Visceral malignant melanoma develops in the biliary tract, including the gallbladder. As both primary and metastatic gallbladder melanomas may show similar of the same growth patterns, the differential diagnosis between these two conditions is often difficult. Primary gallbladder melanoma is more likely if the tumor shows a polypoid or lobulated and in particular papillary growth pattern, is a solitary lesion, and is associated with junctional activity in the adjacent mucosa. In contrast, metastatic lesions are more commonly multiple, flat, and without junctional changes. Apart from neuroendocrine tumors, other neuroectodermal neoplasms can develop as primary tumors in the gallbladder. Rare primary neoplasms in this organ include germ cell tumors, rhabdoid tumors, perivascular epithelioid cell tumors, and hemolymphatic neoplasms. Apart from malignant melanoma, numerous other malignancies can metastasize to the gallbladder, renal cell carcinoma being a particularly common metastasizing tumor. Malignant Melanoma of the Gallbladder Pathogenic Pathways Few melanocytes are present in the normal gallbladder mucosa, and it has been suggested that malignant melanomas take their origin from these cells that have spread from the neural crest to the gallbladder during oncogenesis. Primitive Neuroectodermal Tumor (PNET) of the Gallbladder Differential Diagnosis Differential diagnosis on conventionally stained sections mainly includes other small cell tumors occurring in the gallbladder, e.g., small cell carcinoma or lymphoma. Differential Diagnosis Gallbladder paraganglioma may occur as a component of multiple paragangliomas, involving the common bile duct and the liver in addition to the gallbladder (Ferrell et al. 1990).

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Gallbladder Metastasis of Renal Cell Carcinoma

Cited by 21 publications

References 2 publications

An unusual gall-bladder polyp - site of metastatic renal cell carcinoma: a case report

An unusual gall-bladder polyp - site of metastatic renal cell carcinoma: a case report

Metastases from Cancers of the Urogenital Tract

Melanocytic, Neuroectodermal, Germ Cell, Rhabdoid, Perivascular Epithelioid Cell, Hemolymphatic, and Metastatic Tumors of the Gallbladder

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