Gallbladder Function Is Altered in Sickle Hemoglobinopathy

Everson, Gregory T.; Németh, Antal; Kourourian, Soheila; Zogg, Donald L.; Leff, Nancy Berger; Dixon, Donna L.; Githens, John H.; Pretorius, Dolores H.

doi:10.1016/s0016-5085(89)80018-6

Cited by 42 publications

(18 citation statements)

References 30 publications

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“…However, cholelithiasis is often asymptomatic and can lead to serious complications (cholecystitis, cholangitis, pancreatitis, septicemia starting in the bile) which can jeopardize patients' lives [2] [3]. If excessive bilirubin excretion related to chronic hemolysis is a major risk factor for gallstones formation, other conducive factors which have not been identified yet could intervene [1] [4]. Many studies show that the prevalence of cholelithiasis in patients with sickle cell disease increases with age and affects 6% of patients before 15 years of age and more than 50% of young adults [1] [5] [6].…”

Section: Introductionmentioning

confidence: 99%

Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Kouéta¹,

Kaboret²,

Yonaba³

et al. 2015

OJPed

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Introduction: Sickle cell disease (SCD) causes chronic hemolysis which is a risk factor for cholelithiasis. Its development may lead to severe and life-threatening complications. Objective: Determine the prevalence of cholelithiasis, the conditions of diagnosis and related factors. Materials and Method: We retrospectively reviewed records of 110 patients with sickle cell disease followed up in Charles de Gaulle University Pediatric Hospital from January 2003 to December 2013, including 103 patients who had abdominal ultrasonography. Results: Cholelithiasis prevalence was 24.3%. The mean age of patients was 10.8 years, (range 3 to 15 years). Sex ratio was 2.1. In 88% cases, cholelithiasis was diagnosed based on the characteristic symptoms of right hypocondrial pain, fever and icterus. Most factors associated with cholelithiasis were as follows: age above 10 years (OR = 4), occurrence of at least three (03) vaso-occlusive crises per year (OR = 7.6), history of blood transfusion (OR = 8), right hypochondrial pain (OR = 4.5) and icterus (OR = 15). Only 20% of patients suffering from a symptomatic cholelithiasis underwent laparoscopic cholecystectomy and results were conclusive. Conclusion: Patients with sickle cell disease, especially those aged above 10, should be routinely tested for cholelithiasis using abdominal ultrasonography at least once a year. Because of the difficulties in managing evolutive complications in case of an emergency in our context, we advocate laparoscopic cholecystectomy of any cholelithiasisas soon as it is diagnosed in children with sickle cell disease.

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Section: Introductionmentioning

confidence: 99%

Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Kouéta¹,

Kaboret²,

Yonaba³

et al. 2015

OJPed

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“…However, many SCD patients with marked haemolysis do not develop gallstones. Thus, abnormalities in gallbladder function or bile acid metabolism may contribute to gallstone formation in these patients 8 .…”

Section: Introductionmentioning

confidence: 99%

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Attalla¹,

Karrar²,

Ibnouf³

et al. 2013

Af Hlth Sci

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Background: SCA causes chronic haemolysis which is a risk factor for cholelithiasis. Objective: To determine the prevalence and outcome of children with SCA complicated with gallstones treated at the sickle cell clinic at the children emergency hospital Khartoum state. Methods: 261 patients age 4 months to 16 years were studied. AUS examination was carried out. The 30 patients in whom gall stones were detected followed prospectively from June 1996 to September 2009 when a second AUS examination was obtained.Results: Gall stones occurred in 30 patients of whom four were lost to follow up in the first year. The overall prevalence of cholelithiasis was 11.5% and it increased with age. The youngest patient with cholelithiasis was 2 1/2 years old. Haematological variables, bilirubin and sex did not identify a subgroup of patients at higher risk for gallstones. All the patients were asymptomatic at the time of diagnosis. One patient developed symptoms 3years after the diagnosis and he was submitted to surgery. The 25 remaining asymptomatic patients were followed up for 13 years and none of them presented complications related to cholelithiasis during this period. Conclusion: The prevalence of cholelithiasis in Sudanese children and adolescents with SCA was significant. The large majority patients remained asymptomatic over a long period. African Health Sciences 2013; 13(1): 154 -159 http://dx.doi.org/10.4314/ahs.v13i1.21

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“…Cost analysis indicates that the ultimate cost of laparoscopic cholecystectomy is significantly less that of open cholecystectomy [3,7]. The laparoscopic technique decreases hospitalization time in this population without increasing complications [6].…”

Section: Discussionmentioning

confidence: 99%

“…Cholelithiasis often complicates sickle cell disease: 50% of patients with sickle cell anemia (SS) have gallstones by the age of 20 [3], and 75% of these patients become symptomatic [14]. Patients with sickle cell disease who undergo Correspondence to: P. de Lagausie surgery are considered to be at greater risk for perioperative complications than those without this disorder [11].…”

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confidence: 99%