Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Kouéta, Fla; Kaboret, Sonia; Yonaba, Caroline; Kaboré, Aïssata; Li, Dao; Daïla, Sak-Wend-Tongo; Bandré, Emile; Yé, Diarra

doi:10.4236/ojped.2015.53039

Cited by 3 publications

(4 citation statements)

References 19 publications

(28 reference statements)

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“…In contrast to our findings, Koueta et al [42] found the prevalence of Cholelithiasis to be 24.3% among children with sickle cell anaemia in Burkina Faso (West Africa), despite having a study population and perhaps environmental factors similar to this study. The higher prevalence they reported compared to this and others within sub-Saharan Africa may be attributable to differences in study design; the Burkina Faso study was a 10 year retrospective review of abdominal ultrasound reports from their clinic over ten years.…”

Section: Discussioncontrasting

confidence: 99%

Cholelithiasis in Children with Sickle Cell Anaemia: A Cross-Sectional Analysis from Northeast Nigeria

Ajani¹,

Jalo²,

Saad³

2019

OJPed

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Background: Nigeria contributes 30% to the global sickle cell anaemia burden. Cholelithiasis occurs commonly in children with sickle cell anaemia and may remain undiagnosed, mimic abdominal vaso-occlusive crises or become complicated by calculus cholecystitis. Early identification of children with sickle cell anaemia who have Cholelithiasis reduces the chances of misdiagnosis, mistreatment and improves outcomes. There is limited knowledge about the prevalence of Cholelithiasis among Nigerian children with sickle cell anaemia. The present study aimed to determine the prevalence of Cholelithiasis in children with sickle cell anaemia in Gombe, northeast Nigeria. Methodology: This was a cross-sectional analysis of children with sickle cell anaemia being followed-up at the sickle cell centre of the Federal Teaching Hospital, Gombe, northeast Nigeria. We consecutively recruited 294 children aged 2-17 years while in steady state from June to November 2017. Quantitative data were collected from parents/caregivers via a researcher administered questionnaire and cholecystosonography performed after a minimum of 8-hour fast. Predictors of Cholelithiasis were examined using binary logistic regression. Results: The mean age of children with sickle cell anaemia was 9.0 ± 4.5 years. The prevalence of Cholelithiasis in children with sickle cell anaemia in steady state was 4.8%. Children aged 15-17 years had 12 times higher odds of having Cholelithiasis [AOR = 12.268 (95% CI = 1.3-112.8)]. Conclusion: The prevalence of Cholelithiasis in children with sickle cell anaemia though generally low, increases progressively with age to peak during middle to late adolescence.

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Section: Discussioncontrasting

confidence: 99%

Cholelithiasis in Children with Sickle Cell Anaemia: A Cross-Sectional Analysis from Northeast Nigeria

Ajani¹,

Jalo²,

Saad³

2019

OJPed

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“…Indeed, in our series, patients who have been transfused more than three times since birth were 3 times more likely to develop cholelithiasis. The same observation was made by Koueta in Burkina Faso [ 14 ]. In the USA, a study on the effects of chronic transfusions on abdominal sonographic abnormalities in children with sickle cell anemia reported that gallbladder disease was correlated with older age ( p =0.002), longer duration of transfusions ( p =0.034), and higher total bilirubin ( p ≤ 0.001) [ 15 ].…”

Section: Discussionsupporting

confidence: 80%

“…No significant association was found between VOC frequency and the occurrence of LB. Koueta reported a significant risk (OR = 7.6) when children had at least three VOCs per year [ 14 ]. Alhawsawi in Saudi Arabia and Martins in Brazil reported similar results to ours with a higher prevalence of LB in children of phenotype SS compared to S β -thalassemias and SC without the difference being significant [ 11 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Associated Factors of Cholelithiasis among Younger Children with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease in Brazzaville, Congo

Galiba Atipo Tsiba,

Mikia,

Elira Samba

et al. 2023

Anemia

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Introduction. Chronic hemolysis predisposes sickle cell patients to the development of gallstones. Their frequency increases with age, but they may appear early in young children. In the absence of management, they expose the patient to complications that can hinder the quality of life and sometimes even death. This survey aimed to identify the associated factors of the occurrence of cholelithiasis. Materials and Methods. It was a case-control study carried out between January 2017 and June 2022 at the National Reference Center for Sickle Cell Disease (SCD) “Antoinette Sassou N’guesso” in Brazzaville. It concerned 37 children with cholelithiasis. Sociodemographic (socioeconomic status and diet) and clinical (body mass index, frequency of vasoocclusive crises and hospitalization for vasoocclusive crises, number of blood transfusion, and chronic complications) as well as hematological examination (type of SCD and blood count in the intercritical period) and hydroxyurea treatment were compared with those of 74 children with no clinical and radiographic signs of cholelithiasis. The chi-squared statistical test and the odds ratio were used for the comparison ( p < 0.05 ). Results. The average age was 9.70 ± 1.73 years. The 10–12 age group was the most represented (22 cases or 59.45%), followed by 7- to 9-year-olds (12 cases or 32.43%). Three children (8.10%) were 6 years old. The sex ratio was 0.68 vs. 1.38. Factors associated with cholelithiasis were low socioeconomic status (83.78% vs. 45.95%; IC 95% 1.46−3.89; p ≤ 0.001 ), a higher number of blood transfusions (5.54 ± 1.22 vs. 2.46 ± 1.13; IC 95% 1.55−6.70; p ≤ 0.001 ), and irregular systematic monitoring (5.54 ± 1.22 vs. 2.46 ± 1.13; IC 95% 1.55−6.70; p ≤ 0.001 ). Conclusion. A national strategy to facilitate access to care for patients living with sickle cell disease is imperative. Moreover, emphasis should be placed on the prevention and early management of acute complications of SCD.

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“…Initially, the literature search retrieved 1135 published articles. After exclusion of studies because of irrelevance and insufficient data to estimate the outcomes of interest, a total of 34 eligible studies published from 1977 to 2020, which met the eligibility for data extraction and analyses, were used for qualitative and quantitative synthesis; 15 studies from Africa, 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 seven studies from the South America and North America, 42 , 43 , 44 , 45 , 46 , 47 , 48 seven studies from Asia, 8 , 49 , 50 , 51 , 52 , 53 , 54 and four studies from Europe. 55 , 56 , 57 , 58 Overall, this analysis included a total of 6771 SCD patients.…”

Section: Resultsmentioning

confidence: 99%

Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

et al. 2021

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Sickle cell disorders are the most common hemoglobinopathies worldwide. Clinical variability of sickle cell disease (SCD) and susceptibility to its complications have been attributed to hematologic, genetic, and other influencing factors. This review aimed to provide further summary and analyses of the prevalence and factors associated with cholelithiasis among patients with SCD. A systematic database search was conducted in MEDLINE (PubMed), ScienceDirect, Google Scholar, World Health Organization Virtual Health Library, Cochrane Library databases, and System for Information on Gray Literature in Europe (SIGLE). Pooled prevalence, odds ratio (OR), and standardized mean difference (SMD) with the corresponding 95% confidence interval (CI) were calculated using Comprehensive Meta‐Analysis Software version 3.3. A total of 34 studies that fulfilled the eligibility criteria were included in the analyses. The overall prevalence of cholelithiasis among SCD patients was 25.3% (95% CI 19.4–32.3%). The risk of developing cholelithiasis was significantly associated with lower total hemoglobin level (SMD = −0.45; P = 0.002), lower hemoglobin F (HbF) level (SMD = −0.85; P = 0.003), higher total serum bilirubin level (SMD = 1.15; P < 0.001), higher reticulocytes count (SMD = 0.44; P = 0.007), and UDP‐glucuronosyltransferase‐1A1 enzyme (UGT1A1) promoter polymorphism. This review provides a comprehensive view of the high rate of cholelithiasis and its associated factors in SCD patients.

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Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Cited by 3 publications

References 19 publications

Cholelithiasis in Children with Sickle Cell Anaemia: A Cross-Sectional Analysis from Northeast Nigeria

Cholelithiasis in Children with Sickle Cell Anaemia: A Cross-Sectional Analysis from Northeast Nigeria

Associated Factors of Cholelithiasis among Younger Children with Sickle Cell Disease at the National Reference Center for Sickle Cell Disease in Brazzaville, Congo

Correlates of gallbladder stones among patients with sickle cell disease: A meta‐analysis

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