Gallbladder disease in Shetland Sheepdogs: 38 cases (1995–2005)

Aguirre, Ale L; Randolph, John F.; Yeager, Amy E.; Keegan, Alicia M; Harvey, Hugh; Erb, Hollis N.

doi:10.2460/javma.231.1.79

Cited by 136 publications

(260 citation statements)

References 43 publications

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“…Because GBM formation has a breed predilection for Shetland sheepdogs, is reportedly a disease of older dogs, and is suspected to be increasing in incidence, we chose to control for these variables by selecting control dogs on the basis of matching breed and corresponding in age and year of hospital accession as closely as was possible to the dog diagnosed with a GBM. Control dogs were not matched by sex based on the lack of evidence of an association with GBM formation 1, 3, 4, 6…”

Section: Methodsmentioning

confidence: 99%

“…The syndrome was reported as a rare postmortem finding before 10 years ago and has emerged as one of the most commonly recognized causes of gallbladder disease in the dog 1, 2, 3, 4, 5, 6, 7, 8, 9, 10. The extent to which diagnosis of GBM formation can be attributed to increased use of abdominal ultrasonography in dogs is unknown.…”

mentioning

confidence: 99%

“…Surgical removal of the gallbladder carries a good long‐term prognosis for some dogs. However, surgery often is associated with a high mortality rate, with a median 2‐week mortality of 27% (range, 7–45%) 1, 2, 3, 4, 8, 9, 11…”

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confidence: 99%

“…Several predisposing factors for GBM formation in dogs have been identified or are suspected such as concurrent hypothyroidism or hyperadrenocorticism,6 hyperlipidemia,3, 10 and poor gallbladder motility 12. However, the underlying cause of GBM formation essentially is unknown.…”

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confidence: 99%

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Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case‐Control Study

Gookin

Correa

Peters

et al. 2015

Veterinary Internal Medicne

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BackgroundThe cause of gallbladder mucocele (GBM) formation in dogs currently is unknown. Many available drugs represent a newer generation of xenobiotics that may predispose dogs to GBM formation.ObjectiveTo determine if there is an association between the histologic diagnosis of GBM in dogs and administration of selected drugs.AnimalsEighty‐one dogs with a histologic diagnosis of GBM and 162 breed, age, and admission date‐matched control dogs from a single referral institution.MethodsMedical records of dogs with GBM and control dogs from 2001 to 2011 were reviewed. Owner verification of drug history was sought by a standard questionnaire. Reported use of heartworm, flea, and tick preventatives as well as nonsteroidal anti‐inflammatory drugs, analgesics, corticosteroids, or medications for treatment of osteoarthritis was recorded.ResultsDogs with GBM were 2.2 times as likely to have had reported use of thyroxine (as a proxy for the diagnosis of hypothyroidism) as control dogs (95% confidence interval [CI], 0.949–5.051), 3.6 times as likely to have had reported treatment for Cushing's disease (95% CI, 1.228–10.612), and 2.3 times as likely to have had reported use of products containing imidacloprid (95% CI, 1.094–4.723). Analysis of a data subset containing only Shetland sheepdogs (23 GBM and 46 control) indicated that Shetland sheepdogs with GBM formation were 9.3 times as likely to have had reported use of imidacloprid as were control Shetland sheepdogs (95% CI, 1.103–78.239).Conclusions and Clinical ImportanceThis study provides evidence for an association between selected drug use and GBM formation in dogs. A larger epidemiologic study of Shetland sheepdogs with GBM formation and exposure to imidacloprid is warranted.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

See 2 more Smart Citations

Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case‐Control Study

Gookin

Correa

Peters

et al. 2015

Veterinary Internal Medicne

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“…A ocorrência de colelitíase em cães e gatos é rara (ROTHUIZEN, 2001) e pode ser encontrada nos ductos biliares intrahepáticos (hepatolitíase), ducto cístitico, esfíncter de Oddi ou na vesícula biliar (colecistolitíase), sendo a colecistolitíase a mais comum (AGUIRRE, 2007). O desenvolvimento da litíase é decorrente de estase biliar, infl amação ou infecção (SCHAFER, 1993).…”

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