Galla Chinensis, a Traditional Chinese Medicine: Comprehensive review of botany, traditional uses, chemical composition, pharmacology and toxicology

Ren, Yuanyuan; Zhang, Xiaorui; Li, Ting-na; Zeng, Yijia; Huang, Qinwan

doi:10.1016/j.jep.2021.114247

Cited by 37 publications

(23 citation statements)

References 98 publications

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“…Tannins have exerted positive effects on growth performance, gut morphology, and antioxidant activity in broilers under normal and stressful conditions in previous studies ( 12 – 15 ). Galla Chinensis has long been used as a traditional medicine in China, and its main bioactive component is HT, gallotannins ( 16 ). Recently, 300 mg/kg Galla Chinensis tannin (GCT) addition in the broiler diet was shown to improve growth performance and immune functions ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Yuan

Xu²,

Ma³

et al. 2023

Front. Vet. Sci.

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Herein, Galla Chinensis tannin (GCT) was examined for its influence on preventing lipopolysaccharide (LPS)-induced liver damage in broiler chickens. Approximately 486 one-day-old healthy broilers were randomly allocated to 3 treatment groups (control, LPS, and LPS + GCT). The control and LPS groups were fed a basal diet and the LPS+GCT group was fed the basal diet supplemented with 300 mg/kg GCT. LPS was intraperitoneally injected (1 mg/kg body weight BW) in broilers in the LPS and LPS+GCT groups at 17, 19, and 21 days of age. The results manifested that dietary GCT addition attenuated LPS-induced deleterious effects on serum parameters and significantly increased serum immunoglobulin and complement C3 concentrations relative to the control and LPS groups. Dietary supplementation of GCT inhibited LPS-induced increase in broiler hepatic inflammatory cytokines, caspases activities, and TLR4/NF-κB pathway-related gene mRNA expression. Therefore, 300 mg/kg GCT addition to the diet improved the immune function of broilers and inhibit liver inflammation by blocking the TLR4/NF-κB pathway. Our findings provide support for the application of GCT in poultry production.

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Section: Introductionmentioning

confidence: 99%

Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Yuan

Xu²,

Ma³

et al. 2023

Front. Vet. Sci.

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“…Galla chinensis is a traditional Chinese medicine, and is widely available and used in China. One of the main bioactive components of Galla chinensis is hydrolysable TA, which is a glycoside or ester formed by the combination of gallic acid and diacid with glucose called gallotannins [ 10 ]. Tannic acid was once thought of an anti-nutritional feed additive for monogastric animals due to their binding properties with carbohydrates, proteins, minerals, and digestive enzymes, leading to the decrease of bioavailability of nutrients in feed [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Tannic Acid Extracted from Galla chinensis Supplementation in the Diet Improves Intestinal Development through Suppressing Inflammatory Responses via Blockage of NF-κB in Broiler Chickens

Jing

Niu

Liu

et al. 2022

Animals

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The objective of this study was to investigate the effects of adding tannic acid (TA) extracted from Galla chinensis to the diet of broiler chickens on intestinal development. A total of 324 healthy 1-day-old broilers were used in a 42 d study, and divided into two treatment groups at random (six replicates per group). Broilers were either received a basal diet or a basal diet supplemented with 300 mg/kg microencapsulated TA extracted from Galla chinensis. The results showed that dietary supplemented with 300 mg/kg TA from Galla chinensis improved intestinal morphology, promoted intestinal mucosal barrier integrity, and elevated mucosal expressions of nutrients transporters and tight junction protein CLDN3 in broilers. Besides, 300 mg/kg TA from Galla chinensis supplementation decreased the concentrations of inflammatory cytokines in serum and intestinal mucosa and reduced the mRNA expression of NF-κB in intestinal mucosa. Above all, supplementation of 300 mg/kg microencapsulated TA extracted from Galla chinensis showed beneficial effects in improving intestinal development, which might be attributed to the suppression of inflammatory responses via blockage of NF-κB in broiler chickens. These findings will support the use of TA sourced from Galla chinensis in poultry industry.

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“…Multi-component Chinese medicine formulas are commonly considered to have multi-component, multipathway, and multi-target effects [70][71][72]. Owing to the lack of quantitative and objective data supporting their efficacy and safety, clarifying the pharmacological action of multiple components in a single herb or Chinese medicine formula is difficult, thus hindering the international community's acceptance of multicomponent Chinese medicine formulas [73].…”

Section: Network Pharmacologymentioning

confidence: 99%

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

Zhang

Chen

Tang

et al. 2023

Acta Materia Medica

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For hundreds of years, the drug discovery and development industry has aimed at identifying single components with a clear mechanism of action as desirable candidates for potential drugs. However, this conventional strategy of drug discovery and development has faced challenges including a low success rate and high development costs. Herein, we critically review state-of-the-art drug discovery and development based on multi-component Chinese medicine formulas. We review the policies and application status of new drugs based on multi-component Chinese medicines in the US, China, and the European Union. Moreover, we illustrate several excellent cases of ongoing applications. Biomedical technologies that may facilitate drug discovery and development based on multi-component Chinese medicine formulas are discussed, including network pharmacology, integrative omics, CRISPR gene editing, and chemometrics. Finally, we discuss potential problems and solutions in pre-clinical and clinical research in drug discovery and development based on multi-component Chinese medicine formulas. We hope that this review will promote discussion of the roles of multi-component Chinese medicine formulas in the discovery and development of new drugs for the treatment of human diseases.

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Galla Chinensis, a Traditional Chinese Medicine: Comprehensive review of botany, traditional uses, chemical composition, pharmacology and toxicology

Cited by 37 publications

References 98 publications

Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Effects of dietary Galla Chinensis tannin supplementation on immune function and liver health in broiler chickens challenged with lipopolysaccharide

Tannic Acid Extracted from Galla chinensis Supplementation in the Diet Improves Intestinal Development through Suppressing Inflammatory Responses via Blockage of NF-κB in Broiler Chickens

Multi-component Chinese medicine formulas for drug discovery: State of the art and future perspectives

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