Tannic Acid Extracted from Galla chinensis Supplementation in the Diet Improves Intestinal Development through Suppressing Inflammatory Responses via Blockage of NF-κB in Broiler Chickens

Jing, Changwei; Niu, Jiaxing; Liu, Yang; Jiao, Ning; Huang, Libo; Jiang, Shuzhen; Yan, Lei; Yang, Weiren; Li, Yang

doi:10.3390/ani12182397

Cited by 10 publications

(8 citation statements)

References 45 publications

(60 reference statements)

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“…This study found that jejunal pro-inflammatory mediators (IL-8, IL-1β, iNOS, IFN-γ) were significantly upregulated, the anti-inflammatory mediator (IL-10) was significantly downregulated in broilers with the CCP challenge, and these results suggested that CCP-infected broilers elicited an intestinal inflammatory response in the jejunum. In our study, dietary supplementation with 1000 mg/kg TA significantly diminished pro-inflammatory mediators and elevated anti-inflammatory mediators with CCP challenge, consistent with previous studies [ 43 , 44 , 45 ]. These results suggest that dietary supplementation with 1000 mg/kg TA is beneficial in alleviating intestinal inflammatory responses in broilers co-infected with CCP.…”

Section: Discussionsupporting

confidence: 93%

Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium perfringens

Zhang,

Xu,

Liu

et al. 2024

Animals

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The purpose of this study was to determine the efficacy of tannic acid on the antioxidative function, immunity, and intestinal barrier of broilers co-infected with coccidia and Clostridium perfringens (CCP). A total of 294 1-day-old arbor acres(AA) broilers were divided into three groups: control group (CON), CCP co-infected group (CCP), and 1000 mg/kg TA + CCP co-infected group (CTA). This trial lasted for 28 days. The results showed that the CCP group decreased the activity of glutathione peroxidase (GSH-Px), total superoxide dismutase (T-SOD), catalase (CAT), and total antioxidant capacity (T-AOC) levels and increased the contents of hydrogen peroxide (H2O2) and malondialdehyde (MDA) in the jejunum (p < 0.05). The mRNA levels of GSH-Px3 and CAT in the liver and jejunum, and the mRNA levels of GSH-Px3, SOD, HO-1, and NAD(P)H quinone oxidoreductase I (NQO1) in the liver were down-regulated by CCP challenge (p < 0.05). In addition, the Keap1 and Nrf2 mRNA levels in the liver and jejunum, jejunal glutathione S-transferase (GST), and heme-oxygenase-1 (HO-1) were upregulated in the CCP group compared with CON (p < 0.05). The mRNA levels of interleukin 8 (IL-8), IL-1β, inducible nitric oxide synthase (iNOS), and interferon γ (IFN-γ) in the jejunum were elevated, and jejunal mRNA levels of IL-10, zonula occludens protein1 (ZO-1), claudin-1, claudin-2, and occludin were decreased in the CCP treatment (p < 0.05). Dietary supplementation with 1000 mg/kg TA increased the activity of GSH-Px, T-SOD, CAT, and T-AOC and decreased the contents of H2O2 and MDA in the jejunum (p < 0.05). Compared with the CCP group, TA decreased the mRNA level of Keap1 and Nrf2 in the liver and jejunum, increased the GSH-Px3, SOD, and CAT mRNA in the liver, and alleviated the rise of IL-8, IL-1β, iNOS, and IFN-γ and decrease in IL-10, occludin gene expression in the jejunum (p < 0.05). In conclusion, the addition of 1000 mg/kg TA to the diet improved the jejunal barrier, mitigated the jejunal inflammation, and increased the antioxidant capacity of the liver and jejunum through the activation of the transcription factor Nrf2 downstream of the Nrf2-Keap1 pathway in broilers with NE condition.

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Section: Discussionsupporting

confidence: 93%

Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium perfringens

Zhang,

Xu,

Liu

et al. 2024

Animals

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“…Moreover, although the protein expression of tight junction (Occludin and Claudin‐2) was not affected by dietary treatment, TA significantly downregulated pro‐inflammatory cytokines (IL‐1β and TNF‐α) expression at the protein level in the jejunum compared to the CON. These results further suggested that TA not only does not cause damage to the intestinal barrier but may also have the potential to decelerate intestinal inflammation [45].…”

Section: Discussionmentioning

confidence: 99%

Tannic acid extracted from gallnut improves intestinal health with regulation of redox homeostasis and gut microbiota of weaned piglets

Deng,

Wang,

Wang

et al. 2024

Animal Research and One Health

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The objective of this study is to evaluate the effects of tannic acid (TA) derived from gallnut supplementation on growth performance and health status of weaned piglets. A total of 432 weanling piglets (7.05 ± 1.05 kg) were randomly allocated into 4 treatment groups with 6 replicates of 18 pigs/pen. Piglets were fed either a basal diet (CON), or basal diets supplemented with 1.5 kg/t TA, 3.0 kg/t TA, or 1.8 kg/t zinc oxide (ZnO) for 21 days. The results showed that, compared to the CON, dietary TA supplementation did not affect (p > 0.05) growth performance and serum biochemistry of weaned piglets. However, 3.0 kg/t TA had higher SOD, GPX, and CAT activities and a lower MDA concentration in the jejunum than those of the CON or the ZnO group. Meanwhile, 3.0 kg/t TA increased (p < 0.05) villus height and villus height/crypt depth, and decreased (p < 0.05) crypt depth in the small intestine. Dietary TA also downregulated (p < 0.05) IL‐1β and TNF‐α expression in jejunum. Furthermore, 3.0 kg/t TA reduced (p < 0.05) the abundance of Candidatus Brocadia and Escherichia‐Shigella in cecal digesta. Notably, both Candidatus Brocadia and Escherichia‐Shigella had a negative correlation with antioxidant enzymes activities (R < −0.60, p < 0.01), but Escherichia‐Shigella was positively correlated with MDA concentrations (R = 0.44, p < 0.05) in the jejunum. In conclusion, compared to the CON, 3.0 kg/t TA supplementation improved the gut health status of weaned piglets, potentially by regulating redox homeostasis and gut microbiota.

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“…Li et al [ 89 ] found that supplementation with dandelion tannins or soy isoflavones increased the jejunal VH and decreased the jejunal CD. Jing et al [ 90 ] found that adding tannins to broiler diets increased VH/CD and decreased CD. Dietary astragalus polysaccharide supplementation in broilers increased the jejunal VH/CD and decreased the jejunal CD [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Terminalia chebula Extract on Growth Performance, Immune Function, Antioxidant Capacity, and Intestinal Health of Broilers

Cheng,

Liu,

Wang

et al. 2024

Animals

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Terminalia chebula extract (TCE) has many physiological functions and is potentially helpful in maintaining poultry health, but its specific effect on the growth of broilers is not yet known. This research investigated the effects of dietary Terminalia chebula extract (TCE) supplementation on growth performance, immune function, antioxidant capacity, and intestinal health in yellow-feathered broilers. A total of 288 one-day-old yellow-feathered broilers were divided into four treatment groups (72 broilers/group), each with six replicates of 12 broilers. The broilers were given a basal diet of corn–soybean meal supplemented with 0 (control), 200, 400, and 600 mg/kg TCE for 56 d. The results demonstrated that, compared with the basal diet, the addition of TCE significantly increased (linear and quadratic, p < 0.05) the final body weight and overall weight gain and performance and decreased (linear and quadratic, p < 0.05) the feed-to-gain ratio in the overall period. Dietary TCE increased (linear, p < 0.05) the levels of IgM, IL-4, and IL-10 and decreased (linear and quadratic, p < 0.05) the level of IL-6 in the serum. Dietary TCE increased (linear and quadratic, p < 0.05) the levels of IL-2 and IL-4, decreased (linear and quadratic, p < 0.05) the level of IL-1β, and decreased (linear, p < 0.05) the level of IL-6 in the liver. Dietary TCE increased (linear and quadratic, p < 0.05) the level of IgM and IL-10, increased (linear, p < 0.05) the level of IgG, and decreased (linear and quadratic, p < 0.05) the levels of IL-1β and IL-6 in the spleen. Supplementation with TCE linearly and quadratically increased (p < 0.05) the catalase, superoxide dismutase, glutathione peroxidase, and total antioxidant capacity activities while decreasing (p < 0.05) the malonic dialdehyde concentrations in the serum, liver, and spleen. TCE-containing diets for broilers resulted in a higher (linear and quadratic, p < 0.05) villus height, a higher (linear and quadratic, p < 0.05) ratio of villus height to crypt depth, and a lower (linear and quadratic, p < 0.05) crypt depth compared with the basal diet. TCE significantly increased (linear, p < 0.05) the acetic and butyric acid concentrations and decreased (quadratic, p < 0.05) the isovaleric acid concentration. Bacteroidaceae and Bacteroides, which regulate the richness and diversity of microorganisms, were more abundant and contained when TCE was added to the diet. In conclusion, these findings demonstrate that supplementing broilers with TCE could boost their immune function, antioxidant capacity, and gut health, improving their growth performance; they could also provide a reference for future research on TCE.

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Tannic Acid Extracted from Galla chinensis Supplementation in the Diet Improves Intestinal Development through Suppressing Inflammatory Responses via Blockage of NF-κB in Broiler Chickens

Cited by 10 publications

References 45 publications

Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium perfringens

Effect of Tannic Acid on Antioxidant Function, Immunity, and Intestinal Barrier of Broilers Co-Infected with Coccidia and Clostridium perfringens

Tannic acid extracted from gallnut improves intestinal health with regulation of redox homeostasis and gut microbiota of weaned piglets

Effects of Dietary Terminalia chebula Extract on Growth Performance, Immune Function, Antioxidant Capacity, and Intestinal Health of Broilers

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