Gall stones in sickle cell disease in the United Kingdom.

Bond, L; Hatty, S.R.; Horn, M E; Dick, Moira; Meire, Hylton B.; Bellingham, A. J.

doi:10.1136/bmj.295.6592.234

Cited by 88 publications

(76 citation statements)

References 24 publications

(1 reference statement)

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“…The lower incidence of cholelithiasis and the milder clinical manifestations in these patients were related to an unusually high level of foetal haemoglobin which averaged more than 20%. Other studies 28,29,30,31,32,33 reported higher prevalence than this study. In these studies some have used the same diagnostic method as ours 29,31,33 , other used less sensitive methods 30 and the rest used more than one method 28,32 .…”

Section: Resultscontrasting

confidence: 55%

“…Other studies 28,29,30,31,32,33 reported higher prevalence than this study. In these studies some have used the same diagnostic method as ours 29,31,33 , other used less sensitive methods 30 and the rest used more than one method 28,32 . This is because they studied older children and adults 29,30 , and those who studied only children did not include those under 2 years of age 28,31,32,33 .…”

Section: Resultscontrasting

confidence: 55%

“…This trend was also reflected in other studies when they were categorized into age groups 20,28,29,30,32,33 . In this study there was no evidence for a subgroup at higher risk of gallstones because of the haematological factors or sex.…”

Section: Resultssupporting

confidence: 49%

“…In these studies some have used the same diagnostic method as ours 29,31,33 , other used less sensitive methods 30 and the rest used more than one method 28,32 . This is because they studied older children and adults 29,30 , and those who studied only children did not include those under 2 years of age 28,31,32,33 . In this study the number of patients studied was large and the period of follow-up was long however the fact that the ultrasound technique was not optimal -in terms of MHz used -for infants and very young children was a limitation.…”

Section: Resultsmentioning

confidence: 99%

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Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Attalla¹,

Karrar²,

Ibnouf³

et al. 2013

Af Hlth Sci

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Background: SCA causes chronic haemolysis which is a risk factor for cholelithiasis. Objective: To determine the prevalence and outcome of children with SCA complicated with gallstones treated at the sickle cell clinic at the children emergency hospital Khartoum state. Methods: 261 patients age 4 months to 16 years were studied. AUS examination was carried out. The 30 patients in whom gall stones were detected followed prospectively from June 1996 to September 2009 when a second AUS examination was obtained.Results: Gall stones occurred in 30 patients of whom four were lost to follow up in the first year. The overall prevalence of cholelithiasis was 11.5% and it increased with age. The youngest patient with cholelithiasis was 2 1/2 years old. Haematological variables, bilirubin and sex did not identify a subgroup of patients at higher risk for gallstones. All the patients were asymptomatic at the time of diagnosis. One patient developed symptoms 3years after the diagnosis and he was submitted to surgery. The 25 remaining asymptomatic patients were followed up for 13 years and none of them presented complications related to cholelithiasis during this period. Conclusion: The prevalence of cholelithiasis in Sudanese children and adolescents with SCA was significant. The large majority patients remained asymptomatic over a long period. African Health Sciences 2013; 13(1): 154 -159 http://dx.doi.org/10.4314/ahs.v13i1.21

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Section: Resultscontrasting

confidence: 55%

Section: Resultscontrasting

confidence: 55%

Section: Resultssupporting

confidence: 49%

Section: Resultsmentioning

confidence: 99%

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Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Attalla¹,

Karrar²,

Ibnouf³

et al. 2013

Af Hlth Sci

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“…In our study as in Sarnaik and al [13] and Bond and al [14], cholelithiasis was, from the onset, diagnosed in case of symptoms evocative of bile ducts disorders (right hypocondrial pain, icterus and fever) in 88%, 60% and 56% of cases, respectively. On the other hand, in the work of Attala [1] and Parez [3], cholelithiasis was initially detected through a routine ultrasonography.…”

Section: Conditions Of Diagnosismentioning

confidence: 99%

Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Kouéta¹,

Kaboret²,

Yonaba³

et al. 2015

OJPed

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Introduction: Sickle cell disease (SCD) causes chronic hemolysis which is a risk factor for cholelithiasis. Its development may lead to severe and life-threatening complications. Objective: Determine the prevalence of cholelithiasis, the conditions of diagnosis and related factors. Materials and Method: We retrospectively reviewed records of 110 patients with sickle cell disease followed up in Charles de Gaulle University Pediatric Hospital from January 2003 to December 2013, including 103 patients who had abdominal ultrasonography. Results: Cholelithiasis prevalence was 24.3%. The mean age of patients was 10.8 years, (range 3 to 15 years). Sex ratio was 2.1. In 88% cases, cholelithiasis was diagnosed based on the characteristic symptoms of right hypocondrial pain, fever and icterus. Most factors associated with cholelithiasis were as follows: age above 10 years (OR = 4), occurrence of at least three (03) vaso-occlusive crises per year (OR = 7.6), history of blood transfusion (OR = 8), right hypochondrial pain (OR = 4.5) and icterus (OR = 15). Only 20% of patients suffering from a symptomatic cholelithiasis underwent laparoscopic cholecystectomy and results were conclusive. Conclusion: Patients with sickle cell disease, especially those aged above 10, should be routinely tested for cholelithiasis using abdominal ultrasonography at least once a year. Because of the difficulties in managing evolutive complications in case of an emergency in our context, we advocate laparoscopic cholecystectomy of any cholelithiasisas soon as it is diagnosed in children with sickle cell disease.

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Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus

Faillie

Yin

et al. 2016

JAMA Intern Med

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Gall stones in sickle cell disease in the United Kingdom.

Cited by 88 publications

References 24 publications

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Outcome of cholelithiasis in Sudanese children with Sickle Cell Anaemia (SCA) after 13 years follow-up

Cholelithiasis in Children with Sickle Cell Disease in Ouagadougou Pediatric Hospital

Association of Bile Duct and Gallbladder Diseases With the Use of Incretin-Based Drugs in Patients With Type 2 Diabetes Mellitus

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