Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling

Chen, Hung-Lin; Chiang, Po Cheng; Lo, Chia Hui; Lo, Yuan-Hsin; Hsu, Daniel K.; Liu, Fu‐Tong

doi:10.1038/jid.2015.366

Cited by 48 publications

(44 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among tumor-related miRNAs, miR-203 is one of the critical miRNAs that plays important roles in regulating proliferation of several types of cells. miR-203 reduced the PDGF-stimulated proliferation in human airway smooth muscle (HASM) cells (27), and formed the JNK-miR-203-p63 signaling to regulate keratinocyte proliferation and differentiation (28). miR-203 also plays important roles in cancerigenesis.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

et al. 2018

View full text Add to dashboard Cite

Rapid proliferation is one of the critical characteristics of breast cancer. However, the underlying regulatory mechanism of breast cancer cell proliferation is largely unclear. The present study indicated that sevoflurane, one of inhalational anesthetics, could significantly suppress breast cancer cell proliferation by arresting cell cycle at G1 phase. Notably, the rescue experiment indicated that miR-203 was upregulated by sevoflurane and mediated the function of sevoflurane on suppressing the breast cancer cell proliferation. The present study indicated the function of the sevoflurane/miR-203 signaling pathway on regulating breast cancer cell proliferation. These results provide mechanistic insight into how the sevoflurane/miR-203 signaling pathway supresses proliferation of breast cancer cells, suggesting the sevoflurane/miR-203 pathway may be a potential target in the treatment of breast cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

et al. 2018

View full text Add to dashboard Cite

show abstract

“…MicroRNAs play a role in regulating the cashmere growth cycle by targeting various signalling pathways and transcription factors 14 . MiR-203 regulates the differentiation of epithelial keratinocytes and directly inhibits the expression of p63 12 , 15 . MiR-200b and MiR-196a are associated with hair follicle development 16 , 17 .…”

Section: Introductionmentioning

confidence: 99%

The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

Liu

Yang

Zhao

et al. 2018

Sci Rep

View full text Add to dashboard Cite

It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic changes throughout life. In the hair follicle cycle, the initiation of hair follicles is of great significance for hair follicle regeneration. To provide a reference for hair follicle research, our study compared differences in mRNA expression and microRNA expression during the growth and repose stages of cashmere goat skin samples. Through microRNA and mRNA association analysis, we found microRNAs and target genes that play major regulatory roles in hair follicle initiation. We further constructed an mRNA-microRNA interaction network and found that hair follicle initiation and development were related to MiR-195 and the genes CHP1, SMAD2, FZD6 and SIAH1.

show abstract

“…Indeed, ectopic expression or addition of exogenous galectin-7 in the DLD-1 human colon carcinoma cell line [ 55 ] and the neuroblastoma cells SK-N-MC, respectively [ 53 ], drastically reduced tumour cell proliferation. Consistently, galectin-7 knockdown in human keratinocytes results in a hyperproliferative phenotype [ 38 ]. However, ectopic expression of galectin-7 in the B16F1 melanoma cell line did not affect cell growth [ 60 ] indicating that cell context might be important for galectin-7 to modulate cell proliferation.…”

Section: Galectin-7 In Epithelial Homeostasismentioning

confidence: 82%

“…Regarding tumour biology, galectin-7 downregulation correlates with poor tumour differentiation in bladder squamous cell carcinomas [ 63 ] and in vulvar squamous cell carcinoma [ 64 ]. Recently, Liu and colleagues produced the first mechanistic evidence of a function of galectin-7 in keratinocyte differentiation in vitro [ 38 ]. In fact, in the keratinocyte cell line HaCaT, galectin-7 knockdown reduces cell differentiation as assessed by the expression of keratins.…”

Section: Galectin-7 In Epithelial Homeostasismentioning

confidence: 99%

“…However, galectin-7 is also found in the cytosol, in mitochondria and the nucleus, but its function in the nucleus is largely unknown. Diverse studies suggest an intracellular function of galectin-7 as for example in the regulation of keratinocyte proliferation and differentiation through the c-Jun N-terminal Kinase (JNK1)–miR-203-p63 pathway (see below) [ 38 ]. Galectin-7 expression can be induced via p53 or TNFα activation pathways, and both wild type and p53 mutants harbouring “hot spot” point mutation bind the galectin-7 promoter [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Galectin-7 in Epithelial Homeostasis and Carcinomas

Advedissian

Deshayes

Viguier

2017

IJMS

View full text Add to dashboard Cite

Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. They share a conserved domain for the recognition of carbohydrates (CRD). Although galectins have a common affinity for β-galatosides, they exhibit different binding preferences for complex glycans. First described twenty years ago, galectin-7 is a prototypic galectin, with a single CRD, able to form divalent homodimers. This lectin, which is mainly expressed in stratified epithelia, has been described in epithelial tissues as being involved in apoptotic responses, in proliferation and differentiation but also in cell adhesion and migration. Most members of the galectins family have been associated with cancer biology. One of the main functions of galectins in cancer is their immunomodulating potential and anti-angiogenic activity. Indeed, galectin-1 and -3, are already targeted in clinical trials. Another relevant function of galectins in tumour progression is their ability to regulate cell migration and cell adhesion. Among these galectins, galectin-7 is abnormally expressed in various cancers, most prominently in carcinomas, and is involved in cancer progression and metastasis but its precise functions in tumour biology remain poorly understood. In this issue, we will focus on the physiological functions of galectin-7 in epithelia and present the alterations of galectin-7 expression in carcinomas with the aim to describe its possible functions in tumour progression.

show abstract

Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling

Cited by 48 publications

References 45 publications

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

Sevoflurane suppresses proliferation by upregulating microRNA-203 in breast cancer cells

The intragenic mRNA-microRNA regulatory network during telogen-anagen hair follicle transition in the cashmere goat

Galectin-7 in Epithelial Homeostasis and Carcinomas

Contact Info

Product

Resources

About