Galectin‐7 in the stratum corneum: a biomarker of the skin barrier function

Niiyama, Shiro; Yoshino, T.; Yasuda, Chie; Yu, Xiaopeng; Izumi, Ryotaro; Ishiwatari, Shioji; Matsukuma, Shoko; Mukai, Hiroyuki

doi:10.1111/ics.12326

Cited by 13 publications

(20 citation statements)

References 29 publications

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“…Measurement of galectin‐7 content in tape‐stripped stratum corneum samples from healthy human subjects showed that galectin‐7 increased after barrier disruption induced by sodium dodecyl sulphate. Additionally, stratum corneum galectin‐7 contents correlated with the values of transepidermal water loss, indicating the promoting function of galectin‐7 in skin barrier formation.…”

Section: Keratinocyte Differentiation and Skin Barrier Functionmentioning

confidence: 88%

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The expression and function of galectins in skin physiology and pathology

Liu

2018

Experimental Dermatology

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The galectin family comprises β-galactoside-binding proteins widely expressed in many organisms. There are at least 16 family members, which can be classified into three groups based on their carbohydrate-recognition domains. Pleiotropic functions of different galectins in physiological and pathological processes through extracellular or intracellular actions have been revealed. In the skin, galectins are expressed in a variety of cells, including keratinocytes, melanocytes, fibroblasts, dendritic cells, lymphocytes, macrophages and endothelial cells. Expression of specific galectins is reported to affect cell status, such as activation or death, and regulate the interaction between different cell types or between cells and the extracellular matrix. In vitro cellular studies, in vivo animal studies and studies of human clinical material have revealed the pathophysiologic roles of galectins in the skin. The pathogenesis of diverse non-malignant skin disorders, such as atopic dermatitis, psoriasis, contact dermatitis and wound healing, as well as skin cancers, such as melanoma, squamous cell carcinoma, basal cell carcinoma and cutaneous haematologic malignancy can be regulated by different galectins. Revelation of biological roles of galectins in skin may pave the way to future development of galectin-based therapeutic strategies for skin diseases.

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Section: Keratinocyte Differentiation and Skin Barrier Functionmentioning

confidence: 88%

“…A study showed that the galectin‐7 level in stratum corneum of cheek skin was higher in patients with AD than in healthy controls and the level correlated with the total severity scores, as well as the erythema and pruritus in these areas …”

Section: Cutaneous Inflammationmentioning

confidence: 99%

The expression and function of galectins in skin physiology and pathology

Liu

2018

Experimental Dermatology

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“…Gal‐7 is a member of the β‐galactoside‐binding lectin family, playing a role in the maintenance of epidermal homeostasis. Gal‐7 could be used as a surrogate marker for transepidermal water loss (TEWL), and elevated levels of this protein may suggest skin barrier dysfunction …”

Section: Discussionmentioning

confidence: 99%

Noninvasive analysis of skin proteins in healthy Chinese subjects using an Orbitrap Fusion Tribrid mass spectrometer

Zhang

et al. 2019

Skin Research and Technology

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Objective The objective of this study was to perform noninvasive analysis of skin proteins in a healthy Chinese population using label‐free nanoflow liquid chromatography‐mass spectrometry (nLC‐MS). Materials and Methods Five consecutive tape strippings were obtained from the volar forearm skin of healthy Chinese subjects. Proteins were extracted, and trypsin‐digested peptides were analyzed by a nanochromatography instrument coupled to an Orbitrap Fusion Tribrid mass spectrometer. Data‐dependent acquisition allowed protein identification, which was performed by using Proteome Discoverer software (v2.2). Results In this study, we identified 80 common proteins that were expressed in the skin of healthy Chinese volunteers and divided these proteins into 16 categories, including keratins, cornified envelope proteins, and enzymes associated with substance metabolism. These proteins were closely associated with multiple functions of the skin barrier. Conclusion This study provides a noninvasive method to analyze healthy human epidermal proteins, which are closely associated with the skin barrier. In addition, this study provides a reference for further studies on the application of proteomic technologies to investigate the role of human epidermal proteins in health and disease.

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“…In conjunction with the results of a questionnaire survey of healthy volunteers, the SC Gal‐7 showed a higher expression in group C, leading to the presumption that the expression of SC Gal‐7 may be chronically increased in subjects who tend to have AV. The increased expression of Gal‐7 may cause hyperkeratosis, partially leading to the development of AV, as it reportedly reflects an impairment in skin barrier function and encourages re‐epithelialization . Increased SC Gal‐7 levels suggest the presence of the dry skin .…”

Section: Discussionmentioning

confidence: 99%

“…The expression level of Gal‐7 in the skin is increased during epithelial differentiation . In preliminary studies, we analyzed the proteins that play a role in protecting the skin against damage agents, such as environmental stress . In this study, the usefulness of stratum corneum (SC) NGAL and SC Gal‐7 as biomarkers of AV is studied.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of neutrophil gelatinase‐associated lipocalin and galectin‐7 in tape‐stripped stratum corneum of acne vulgaris

Watanabe

Yoshino

Takahashi

et al. 2018

The Journal of Dermatology

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The usefulness of stratum corneum neutrophil gelatinase-associated lipocalin and stratum corneum galectin-7 as biomarkers of acne vulgaris was studied. A comparison of neutrophil gelatinase-associated lipocalin levels on the cheeks of patients with acne vulgaris at the start of the study and at the time of symptom improvement showed a significant decrease. On the other hand, the galectin-7 levels at the time of symptom improvement were significantly higher than those at the start of the study. Therefore, because the inflammation in the epidermis and hair follicles was reduced after therapy, as a result of the solution of the inflammatory eruptions caused by acne vulgaris, the neutrophil gelatinase-associated lipocalin level also showed a significant decrease after therapy. These results suggest that stratum corneum neutrophil gelatinase-associated lipocalin may be useful as an objective biomarker of changes in acne vulgaris symptoms.

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Galectin‐7 in the stratum corneum: a biomarker of the skin barrier function

Abstract: Measurement of scGal-7 content in tape-stripped samples was useful for the evaluation of the skin barrier function in dry skin conditions such as AD.

Cited by 13 publications

References 29 publications

The expression and function of galectins in skin physiology and pathology

The expression and function of galectins in skin physiology and pathology

Noninvasive analysis of skin proteins in healthy Chinese subjects using an Orbitrap Fusion Tribrid mass spectrometer

Clinical significance of neutrophil gelatinase‐associated lipocalin and galectin‐7 in tape‐stripped stratum corneum of acne vulgaris

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