Galectin-3 as a novel biotarget in cardiovascular alterations associated to development of severe aortic stenosis

Arrieta,; Sádaba,; Alvarez, Fernando; Rodríguez, J.A.; López‐Andrés, Natalia

doi:10.23938/assn.0643

Cited by 7 publications

(8 citation statements)

References 42 publications

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“…Similarly, in a study by Bobrowska et al, the median Gal-3 levels were higher in patients with critically-ill aortic valve stenosis referred to balloon aortic valvuloplasty (BAV), with further prospective TAVR [ 29 ]. In the mentioned study, there was a trend to significance for all-cause mortality in patients with Gal-3 levels exceeding 17.8 ng/mL irrespective of the type of treatment employed (the log rank p = 0.09) [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…Importantly, in experimental animal models, inhibition of Gal-3 blocked aortic valve calcification, cardiac and vascular fibrosis and inflammation [ 30 , 31 ]. These data suggest a key role for Gal-3 in cardiorenal remodeling and dysfunction induced by aldosterone.…”

Section: Discussionmentioning

confidence: 99%

“…These data suggest a key role for Gal-3 in cardiorenal remodeling and dysfunction induced by aldosterone. Moreover, targeting Gal-3 may be an upstream therapeutic option for the treatment of aortic valve and cardiovascular remodeling that accompanies the progression of DAS [ 30 , 31 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

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Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes

Baran

Niewiara

Podolec

et al. 2022

JCDD

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Background: Although degenerative aortic valve stenosis (DAS) is the most prevalent growth-up congestive heart valve disease, still little known about relationships between DAS severity, vascular stiffness (VS), echocardiographic parameters, and serum biomarkers in patients undergoing transcatheter (TAVR) or surgical aortic valve replacement (SAVR). The objective of this study was to identify biomarkers associated with DAS severity, and those that are associated with cardiovascular death (CVD) and episodes of chronic heart failure (CHF) exacerbation. Methods: A total of 137 patients with initially moderate-to-severe DAS were prospectively evaluated for the relationship between DAS severity, baseline VS, and serum biomarkers (uPAR, GDF-15, Gal-3, IL-6Rα, ET-1, PCSK9, RANTES/CCL5, NT-proBNP, and hs-TnT), and were followed-up for 48 months. The prognostic significance of each variable for CVD and CHF risk was measured by hazard ratio of risk (HR), which was calculated by Cox’s proportional hazard model. Results: DAS severity showed correlations with IL-6Rα (r = 0.306, p < 0.001), uPAR (r = 0.184, p = 0.032), and NT-proBNP (r = −0.389, p < 0.001). Levels of ET-1 and Gal-3 were strongly correlated with VS parameters (r = 0.674, p < 0.001; r = 0.724, p < 0.001). Out of 137 patients, 20 were referred to TAVR, 88 to SAVR, and 29 to OMT. In TAVR patients, the highest levels of ET-1, Gal-3, and VS were found as compared to other patients. The highest incidence of CVD was observed in patients who underwent TAVR (35%), compared to SAVR (8%) and OMT (10.3%) (p = 0.004). In a multivariate analysis, ET-1 occurred predictive of CVD risk (HR 25.1, p = 0.047), while Gal-3 > 11.5 ng/mL increased the risk of CHF exacerbation episodes requiring hospital admission by 12%. Conclusions: Our study indicated that ET-1 and Gal-3 levels may be associated with the outcomes in patients with DAS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes

Baran

Niewiara

Podolec

et al. 2022

JCDD

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“…Therefore, we decided to define SR as the reduction of LVESV≥30%. Furthermore, this is one of the most used definitions in the literature [7][8][9]12,14 . Moreover, when comparing this definition of SR with other echocardiographic definitions, the long-term results are similar 10 .…”

Section: Discussionmentioning

confidence: 99%

Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy

2021

An Sist Sanit Navar

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“…Many of the steps involved in the pathogenesis of aortic stenosis (AS) are modulated by Gal-3 and, therefore, presumably also by MCP [88]. Galectin-3 transforms quiescent fibroblasts into myofibroblasts that produce and secrete matrix proteins such as collagen [89,90].…”

Section: Fibrotic Diseasesmentioning

confidence: 99%

Pleiotropic Effects of Modified Citrus Pectin

Eliaz¹,

Raz

2019

Nutrients

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Modified citrus pectin (MCP) has a low-molecular-weight degree of esterification to allow absorption from the small intestinal epithelium into the circulation. MCP produces pleiotropic effects, including but not limited to its antagonism of galectin-3, which have shown benefit in preclinical and clinical models. Regarding cancer, MCP modulates several rate-limiting steps of the metastatic cascade. MCP can also affect cancer cell resistance to chemotherapy. Regarding fibrotic diseases, MCP modulates many of the steps involved in the pathogenesis of aortic stenosis. MCP also reduces fibrosis to the kidney, liver, and adipose tissue. Other benefits of MCP include detoxification and improved immune function. This review summarizes the pleiotropic effects of MCP.

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Galectin-3 as a novel biotarget in cardiovascular alterations associated to development of severe aortic stenosis

Cited by 7 publications

References 42 publications

Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes

Serum and Vascular Stiffness Biomarkers Associated with the Severity of Degenerative Aortic Valve Stenosis and Cardiovascular Outcomes

Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy

Pleiotropic Effects of Modified Citrus Pectin

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