Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy

Abstract

Rol de sCD40L en la predicción de súper-respuesta a la terapia de resincronización cardiaca Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy

Updated insights into predictive biomarkers for response to cardiac resynchronization therapy - A literature review

“…Soluble CD40 Ligand (sCD40L), with a dual role in initiating inflammation and platelet activation, was moderately correlated with super-response [28]. However, the levels of NT-proBNP, hsCRP, IL-6 and TNFα were not significantly different in super-responders [28].…”

“…A prospective study analyzed biomarkers in relation to CRT super-response, defined as a reduction in end- systolic left ventricular volume by ≥30% [28]. Soluble CD40 Ligand (sCD40L), with a dual role in initiating inflammation and platelet activation, was moderately correlated with super-response [28]. However, the levels of NT-proBNP, hsCRP, IL-6 and TNFα were not significantly different in super-responders [28].…”