Galectin-3 and Inflammation

Wan, Lei; Liu, Fu‐Tong

doi:10.4137/gbi.s13921

Cited by 13 publications

(2 citation statements)

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“…Galectins are a family of beta-galactoside-binding proteins that share a consensus sequence in the carbohydrate recognition domain [10]. Among 17 galectin families that have been identified so far, gal3 is the most widely studied family member and can be found intracellular in the cytoplasm and nucleus, as well as extracellularly in various tissues [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Galectin-3 Is Associated with Cardiac Fibrosis and an Increased Risk of Sudden Death

Sherpa

Sonkawade

Jonnala

et al. 2023

Cells

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Background: Myocardial fibrosis is a common postmortem finding among individuals with Sudden Cardiac Death (SCD). Numerous in vivo and in vitro studies have shown that increased galectin-3 (gal3) expression into the myocardium is associated with higher incidence of fibrosis. Although elevated gal3 expression is linked with myocardial fibrosis, its role in predicting the risk of SCD is unknown. Methods: We reviewed the clinical datasets and post-mortem examination of 221 subjects who had died suddenly. We examined myocardial pathology including the extent of cardiac hypertrophy, fibrosis, and the degree of coronary atherosclerosis in these subjects. In a select group of SCD subjects, we studied myocardial gal3 and periostin expression using immunohistochemistry. To further examine if a higher level of circulating gal3 can be detected preceding sudden death, we measured serum gal3 in a porcine model of subtotal coronary artery ligation which shows an increased tendency to develop lethal cardiac arrhythmias, including ventricular tachycardia or fibrillation. Results: Of the total 1314 human subjects screened, 12.7% had SCD. Comparison of age-matched SCD with non-SCD subjects showed that SCD groups had excessive myocardial fibrosis involving both the left ventricular free wall and interventricular septum. In pigs with subtotal coronary artery ligation and SCD, we detected significantly elevated circulating gal3 levels approximately 10 days preceding the SCD event. Immunohistochemistry showed increased myocardial gal3 and periostin expression in pigs that died suddenly, compared to the controls. Conclusion: Our study shows that increased gal3 is associated with a higher risk of myocardial fibrosis and the risk of SCD. This supports the importance of larger translational studies to target gal3 to prevent cardiac fibrosis and attenuate the risk of SCD.

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Section: Introductionmentioning

confidence: 99%

Galectin-3 Is Associated with Cardiac Fibrosis and an Increased Risk of Sudden Death

Sherpa

Sonkawade

Jonnala

et al. 2023

Cells

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“…Plays a role in "cell-cell adhesion, cell matrix interaction, macrophage activation, angiogenesis, metastasis, and apoptosis". Galectin-3 expressed in tumour cells plays an important role in the processes relevant to tumorigenesis such as malignant cell transformation, invasion and metastasis [11]. Initiation tumor cell transformation through interactions with oncogenic Ras proteins (K- Ras) and activation of phosphatidylinositol 3kinase (PI3K) and Raf1, may also influence tumorigenesis through the regulation of cell cycle.…”

Section: Introductionmentioning

confidence: 99%

Study of Serum Adiponectin, Leptin, and Galectin-3 in Breast Cancer

Ibrahim¹,

Ahmed²

2023

djm

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Background: Breast cancer is the most common cancer that threatens the lives of women all over the world. Adipocytokines (adiponectin, leptin), and the β-galactoside-binding proteins (galectin-3) are new suggested parameters for the diagnosis and prognosis of breast cancer. Objective: To find relationship between serum adiponectin, leptin, and galectin-3 and breast cancer diagnosis and prognosis factors. Patients and Methods: A case-control study was done between (August 2021 to June 2022). Totally collected 111 female blood samples from patients that diagnosed with a breast cancer and healthy control, Samples were grouped into Group I (30 healthy control), Group II (43 patients pre-treatment), and Group III (38 patients post-treatment), from Rizgary Teaching Hospital, Nanakali Hospital, Hawler Teaching Hospital- General surgery and Neurosurgical Department, PAR Private Hospital, PAKY Hospital, and Rasul Private Hospital at Iraq-Erbil city and the age 18 up to 77 included in this study. Biochemical tests were performed (Adiponectin, Leptin, Galectin-3). These sample were analysed by using blood serum, statistically analysis the result. Results: The post-treatment, pre-treatment, and control in respectively about (60.52%, 60.46%, and 63.34%) were the majority of the study population (38-57) age group. There is a statistically significant differences between case and control groups in residency, family history, and BMI with a P-vale of (0.08, <0.001, 0.015), respectively. Leptin, adiponectin, and galectin-3 were statistically significant (0.007, <0.01, and <0.01), in respectively. About cancer characteristic galectin-3 was significant with (ER/PR) receptor (P:0.037) and grade (P:0.034), also leptin was significant with the grade (P: 0.025). Conclusion: We concluded that Adiponectin, Leptin, and Galectin-3 were new potential biochemical marker for diagnosis and prognosis the breast cancer, would be useful and important marker for assessing and evaluating grad, and receptor of the therapy plan.

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