The role of galectin-3 in modulation of anxiety state level in mice

Stajic, Dalibor; Selaković, Dragica; Jovičić, Nemanja; Joksimović, Jovana; Arsenijević, Nebojša; Lukic, Miodrag L.; Rosić, Gvozden

doi:10.1016/j.bbi.2019.01.019

Cited by 27 publications

(30 citation statements)

References 52 publications

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“…Furthermore, our future investigations in this field will cover the potential regional differences inside the targeted regions involved in mood regulation. Namely, according to our previous investigations, the possible mechanisms that connect behavioral alterations and the pathophysiological base of cisplatin action may be linked to very specific changes in mood controlling receptors, as well as to the amount of neurotrophic factors in a subregion of the hippocampus [39] instead of overall expression of mood regulators in each brain region responsible for mood regulation.…”

Section: Discussionmentioning

confidence: 99%

N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

et al. 2019

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Since cisplatin therapy is usually accompanied with numerous toxicities, including neurotoxicity, that involve tissue oxidative damage, the aim of this study was to evaluate the possible protective effect of N-acetylcysteine (NAC) on the anxiogenic response to cisplatin (CIS). Thirty-two male Wistar albino rats divided into four groups (control, cisplatin, NAC, and CIS + NAC). All treatments were delivered intraperitoneally. On day one, the control and cisplatin groups received saline while the NAC and CIS + NAC groups were administered with NAC (500 mg/kg). On the fifth day, the control group received saline while the CIS group was treated with cisplatin (7.5 mg/kg), the NAC group again received NAC (500 mg/kg), and the CIS + NAC group was simultaneously treated with cisplatin and NAC (7.5 and 500 mg/kg, respectively). Behavioral testing, performed on the tenth day in the open field (OF) and elevated plus maze (EPM) tests, revealed the anxiogenic effect of cisplatin that was significantly attenuated by NAC. The hippocampal sections evaluation showed increased oxidative stress (increased lipid peroxidation and decline in antioxidant enzymes activity) and proapoptotic action (predominantly by diminished antiapoptotic gene expression) following a single dose of cisplatin. NAC supplementation along with cisplatin administration reversed the prooxidative and proapoptotic effects of cisplatin. In conclusion, the results obtained in this study confirmed that antioxidant supplementation with NAC may attenuate the cisplatin-induced anxiety. The mechanism of anxiolytic effect achieved by NAC may include the decline in oxidative damage that down regulates increased apoptosis and reverses the anxiogenic action of cisplatin.

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Section: Discussionmentioning

confidence: 99%

N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

et al. 2019

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“…These animal experiments suggest that galectin-3 is involved in the overall regulation of physiological responses to psychological stress [25]. Untreated mice lacking galectin-3 expression showed anxiogenic behaviors compared to wild-type animals, and this was associated with lower brain-derived neurotrophic factor (BDNF) gene expression and immunoreactivity in hippocampal tissue (predominantly in the CA1 region) [33]. Interestingly, hippocampal gene expression of the GABA-A receptor subunits 2 and 5 was attenuated in the transgenic mice.…”

Section: Discussionmentioning

confidence: 98%

Higher galectin-3 levels are independently associated with lower anxiety in patients with risk factors for heart failure

Sadlonova

Meyer

Binder

et al. 2020

BioPsychoSocial Med

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Background Galectin-3 promotes the proliferation of neural progenitor cells and is engaged in cell-cell adhesion, cell-matrix interactions, and macrophage activation. In addition, in patients with heart failure this carbohydrate-binding protein is a known prognostic marker for cardiovascular mortality. However, its association with psychological variables has not been investigated so far. Methods Using data from the multicenter, observational Diast-CHF (Diagnostic Trial on Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure) trial, we studied in participants with cardiovascular risk factors (n = 1260, age 66.7 ± 8.0 years, males 51%, left ventricular ejection fraction 60.0 ± 8.1%) the relationship between serum concentrations of galectin-3 and anxiety. Galectin-3 levels were measured by means of a sandwich enzyme-linked immunosorbent assay, and anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS). Results In univariate analysis, there was a weak but significant inverse correlation between galectin-3 and HADS anxiety (rho = − 0.076; p = 0.008). Linear regression models adjusted for sex, age, body-mass index, estimated glomerular filtration rate, left ventricular ejection fraction, 6-min walking distance, the 36-item Short-Form Health Survey (SF-36) subscale physical functioning, and known biomarkers for heart failure confirmed that serum galectin-3 significantly and independently predicted self-rated anxiety (B = -2.413; 95%CI = -2.413–-4.422; p = 0.019). Conclusion In patients with cardiovascular risk factors, serum concentrations of galectin-3 showed an inverse association with anxiety, which was independent of both the severity of physical impairment and established risk factors for the progression of heart failure.

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“…In another study, Stajic et al studied behavioral changes in mice after gal-3 gene deletion, 21 finding that gal-3 gene deletion prevented IL-6 increases and led to a decline in brain-derived neurotrophic factor gene expression and immunoreactivity, as well as a reduction in hippocampal GABA-AR2S, thus attenuating the anxiogenic effect of neuroinflammation. 21 In recent years, there has been an increasing number of studies on the relationship between inflammatory cytokines and schizophrenia. High concentrations of inflammatory mediators have recently been recorded in the serum of schizophrenia patients, such as IL-1b, IL-6, and TNF-a, 5 and neuroinflammation may contribute to the pathogenesis of schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…17 In addition to these studies, gal-3 has also been researched in relation to psychiatric disorders, such as attention deficit hyperactivity disorder, 18 schizophrenia 19,20 and anxiety. 21 To the best of our knowledge, very few studies have evaluated the connection between galectins and schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Serum galectin-3 levels are decreased in schizophrenia

Kılıç

Işık

Demirdaş

et al. 2020

Braz. J. Psychiatry

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Objective: To determine whether changes in serum galectin-3 (gal-3) concentrations in schizophrenia patients have etiopathogenetic importance. Since very little research has assessed the connection between galectins and schizophrenia, we wanted to examine alterations in the inflammatory marker gal-3 in schizophrenia and investigate possible correlations between clinical symptomatology and serum concentrations. Methods: Forty-eight schizophrenia patients and 44 healthy controls were included in this study. The Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were administered to determine symptom severity. Venous blood samples were collected, and serum gal-3 levels were measured. Results: Mean serum gal-3 levels were significantly lower in schizophrenia patients, and there were no significant differences in age or sex with the control group. There was also a significant positive correlation between serum gal-3 concentrations and negative schizophrenia symptoms according to the SANS. Conclusion:The results indicate that gal-3 is decreased in schizophrenia patients, which could contribute to inflammation in the pathogenesis of schizophrenia.

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The role of galectin-3 in modulation of anxiety state level in mice

Cited by 27 publications

References 52 publications

N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

N-Acetylcysteine Protects against the Anxiogenic Response to Cisplatin in Rats

Higher galectin-3 levels are independently associated with lower anxiety in patients with risk factors for heart failure

Serum galectin-3 levels are decreased in schizophrenia

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