Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis

Laan, A.M. van der; Schirmer, Stephan H.; Vries, Margreet R. de; Koning, Jos J. de; Volger, Oscar L.; Fledderus, Joost O.; Bastiaansen, A.J.N.M.; Hollander, Maurits R.; Baggen, Josefien M.; Koch, Karel T.; Baan, Jan; Henriques, Jose P; Schaaf, René J. van der; Vis, Marije M.; Mebius, Reina E.; Kraan, Tineke C. van der Pouw; Quax, Paul H.A.; Piek, Jan J.; Horrevoets, Anton J.G.; Royen, Niels van

doi:10.1093/eurheartj/ehr220

Cited by 47 publications

(64 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prior studies of LGALS2 function and disease associations have been inconsistent and sometimes conflicting. Higher galectin-2 levels in monocytes and macrophages are linked to low arteriogenic response in coronary artery disease patients [53] and inflammation [54]. A case–control study in Japan first reported that the 3279C > T(rs7291467) polymorphism, which reduces galectin expression, was negatively associated with risk of myocardial infarction [55].…”

Section: Discussionmentioning

confidence: 99%

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

et al. 2016

View full text Add to dashboard Cite

BackgroundDNA methylation may mediate effects of air pollution on cardiovascular disease. The association between long-term air pollution exposure and DNA methylation in monocytes, which are central to atherosclerosis, has not been studied. We investigated the association between long-term ambient air pollution exposure and DNA methylation (candidate sites and global) in monocytes of adults (aged ≥55).MethodsOne-year average ambient fine particulate matter (PM2.5) and oxides of nitrogen (NOX) concentrations were predicted at participants’ (n = 1,207) addresses using spatiotemporal models. We assessed DNA methylation in circulating monocytes at 1) 2,713 CpG sites associated with mRNA expression of nearby genes and 2) probes mapping to Alu and LINE-1 repetitive elements (surrogates for global DNA methylation) using Illumina’s Infinium HumanMethylation450 BeadChip. We used linear regression models adjusted for demographics, smoking, physical activity, socioeconomic status, methyl-nutrients, and technical variables. For significant air pollution-associated methylation sites, we also assessed the association between expression of gene transcripts previously associated with these CpG sites and air pollution.ResultsAt a false discovery rate of 0.05, five candidate CpGs (cg20455854, cg07855639, cg07598385, cg17360854, and cg23599683) had methylation significantly associated with PM2.5 and none were associated with NOX. Cg20455854 had the smallest p-value for the association with PM2.5 (p = 2.77 × 10−5). mRNA expression profiles of genes near three of the PM2.5-associated CpGs (ANKHD1, LGALS2, and ANKRD11) were also significantly associated with PM2.5 exposure. Alu and LINE-1 methylation were not associated with long-term air pollution exposure.ConclusionsWe observed novel associations between long-term ambient air pollution exposure and site-specific DNA methylation, but not global DNA methylation, in purified monocytes of a multi-ethnic adult population. Epigenetic markers may provide insights into mechanisms underlying environmental factors in complex diseases like atherosclerosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0202-4) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

et al. 2016

View full text Add to dashboard Cite

show abstract

“…A total of 48 patients with CTO were included at AMC,2 62 patients at the University Hospital Bern16 and 185 patients at the Friedrich-Schiller-University. All patients had a 100% occlusion of a coronary artery.…”

Section: Methodsmentioning

confidence: 99%

“…The degree of collateral artery development influences the outcome after acute myocardial infarction (MI) and furthermore, in stable coronary artery disease (CAD) patients with a well-developed coronary collateral circulation it shows improved long-term survival 1 2. Thus, the stimulation of arteriogenesis is of potential clinical benefit and there is an ongoing debate on the relationship between coronary collateral artery growth (arteriogenesis) and clinical parameters like age, diabetes and medication.…”

Section: Introductionmentioning

confidence: 99%

Clinical parameters associated with collateral development in patients with chronic total coronary occlusion

Hoeven

Teunissen

Werner

et al. 2013

Heart

View full text Add to dashboard Cite

show abstract

“…Galectin-2 and LTA have been shown to be expressed in smooth muscle cells (SMCs) and macrophages in the intima of human atherosclerotic plaques, but not in quiescent or normal medial SMCs (16). Recently, one study in the Japanese population proved that the CC genotype of LGALS2 3279C>T caused high expression of galectin-2 and acted as an inhibitor of arteriogenesis in the murine hindlimb model (18). Another study in the Japanese population revealed an association between the LGALS2 polymorphism and the severity of coronary atherosclerosis through a pathological study of 1,503 consecutive autopsy cases (19).…”

Section: Introductionmentioning

confidence: 99%

Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

et al. 2014

View full text Add to dashboard Cite

Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 () is involved in the cytokine lymphotoxin-α (LTA) cascade that may influence the progress of CAD. The aim of the present study was to assess the association between the 3279C>T (rs7291467) polymorphism and CAD. A total of 562 cases and 572 controls were recruited to examine the association. A systematic meta-analysis was performed to evaluate the contribution of 3279C>T polymorphism to the risk of CAD among 12,093 cases and 11,020 controls. There was no significant association found in the present case-control study. However, the meta-analysis showed that 3279C>T played a protective role in CAD [P=0.008, odds ratio (OR), 0.90; 95% confidence interval (95% CI), 0.82-0.97] and particularly in the Asian population (P=0.006; OR, 0.82; 95% CI, 0.71-0.94). The present case-control study did not find a significant association between 3279C>T and CAD in the Eastern Han Chinese population. However, the meta-analysis indicated that 3279C>T played a protective role in CAD, suggesting an ethnic difference in the association of the locus with CAD.

show abstract

Galectin-2 expression is dependent on the rs7291467 polymorphism and acts as an inhibitor of arteriogenesis

Abstract: Collectively, these results identify galectin-2 as a novel inhibitor of arteriogenesis. Modulation of galectin-2 may constitute a new therapeutic strategy for the stimulation of arteriogenesis in patients with CAD.

Cited by 47 publications

References 25 publications

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

Clinical parameters associated with collateral development in patients with chronic total coronary occlusion

Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

Contact Info

Product

Resources

About