Association between LGALS2 3279C>T and coronary artery disease: A case-control study and a meta-analysis

Abstract

Coronary artery disease (CAD) has become the main cause of mortality worldwide. Lectin galactoside-binding soluble-2 () is involved in the cytokine lymphotoxin-α (LTA) cascade that may influence the progress of CAD. The aim of the present study was to assess the association between the 3279C>T (rs7291467) polymorphism and CAD. A total of 562 cases and 572 controls were recruited to examine the association. A systematic meta-analysis was performed to evaluate the contribution of 3279C>T polymorphism to the risk of CAD among 12,093 cases and 11,020 controls. There was no significant association found in the present case-control study. However, the meta-analysis showed that 3279C>T played a protective role in CAD [P=0.008, odds ratio (OR), 0.90; 95% confidence interval (95% CI), 0.82-0.97] and particularly in the Asian population (P=0.006; OR, 0.82; 95% CI, 0.71-0.94). The present case-control study did not find a significant association between 3279C>T and CAD in the Eastern Han Chinese population. However, the meta-analysis indicated that 3279C>T played a protective role in CAD, suggesting an ethnic difference in the association of the locus with CAD.

Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

“…This single nucleotide polymorphism is located over 380 kb away from the LGALS2 -eMS cg07855639. However, subsequent studies in other Asian and European populations provided mixed results [56–61]. Studies even found the TT genotype, which leads to lower levels of galectin-2, to be associated with more severe coronary stenosis [62] and higher levels of C-reactive protein [60].…”

Molecular genetics of coronary artery disease

“…Resent meta-analysis also demonstrated the association between rs7291467 SNP and MI. 42 This genetic substitution seemed to affect the transcriptional level of galectin-2, which led to altered secretion of LTA, thereby affecting the degree of inflammation. We also found that galectin-2 binds to tubulins, which are important components of microtubules, suggesting a role in intracellular trafficking ( Figure 1).…”

IL-6-174G/C and IL-6-572C/G polymorphisms are associated with increased risk of coronary artery disease

“…It is well known that CAD has multiple causes including environmental and genetic factors (He et al, 2005;Roger et al, 2012). Recently, several studies have indicated that genetic polymorphisms, including those of the MEF2A, CRP, LGALS2, GP78, and MMP-9 genes, are associated with increased risk of CAD (Cha et al, 2014;Foroughmand et al, 2014;Ghaffari et al, 2014;Lian et al, 2014;Opstad et al, 2014).…”