Galectin‐10 mRNA is overexpressed in peripheral blood of aspirin‐induced asthma

Devouassoux, Gilles; Pachot, Alexandre; Laforest, Laurent; Diasparra, Jennifer; Freymond, N.; Ganse, Éric Van; Mougin, Bruno; Pachéco, Yves

doi:10.1111/j.1398-9995.2007.01558.x

Cited by 45 publications

(28 citation statements)

References 41 publications

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“…In peripheral blood, flow-cytometric determination of basophil activation has been proposed for in vitro diagnosis of NSAID hypersensitivity syndrome 22. Galectin -10 mRNA23 and plasma eotaxin 224 have been shown to be elevated in subjects with AERD compared with those with ATA. Several proteomic candidates have been found to be associated with an increased risk of AERD 25.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma

Chang

Park

Jang

et al. 2011

Allergy Asthma Immunol Res

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PurposeAspirin-exacerbated respiratory disease (AERD) has attracted a great deal of attention because of its association with increased asthma severity. However, oral aspirin challenge (OAC) to diagnose AERD is a time-consuming procedure, and some patients experience serious complications. Thus, we evaluated diagnostic values of non-invasive clinical parameters to predict AERD in asthmatic patients.MethodsA total of 836 Korean subjects were recruited from an asthma cohort. They underwent OAC, and clinical parameters including the history of aspirin hypersensitivity, nasal polyposis, and chronic sinusitis of aspirin-tolerant asthma (ATA) and AERD asthmatic patients were compared.ResultsSignificant differences (P<0.01) were found in eight parameters: age at diagnosis, body mass index, FEV1%, PC20, history of urticaria, nasal polyps, chronic sinusitis, and history of aspirin hypersensitivity. After logistic regression analysis based on the eight clinical parameters, nasal polyps, history of aspirin intolerance, sinusitis, and log [PC20 methacholine] remained significantly associated with AERD (P<0.05). The sensitivity and specificity of the history of aspirin hypersensitivity to predict AERD were 64.7% and 92.0%, respectively, and the positive and negative predictive values were 56.9% and 94.1%, respectively. Overall, the accuracy of the test was 88.2%. The accuracy of the tests for nasal polyps and chronic sinusitis were 67.3% and 60.4%, respectively.ConclusionsAmong clinical parameters associated with AERD, the history of aspirin hypersensitivity has the best positive and negative predictive values for the oral aspirin challenge test. Because the false-positive and -negative rates were still high, additional non-invasive methods are needed to reduce the rate of false outcomes.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma

Chang

Park

Jang

et al. 2011

Allergy Asthma Immunol Res

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“…The upregulation of galectin-10 has been reported in several models of physiological and pathological stresses. Bronchial and nasal inflammation is accompanied by the activation and recruitment of eosinophils, and a corresponding accumulation of galectin-10 in peripheral blood [72], samples of sputum [73], and nasal lavage [74]. Elevated levels of galectin-10 have also been reported in gut biopsies of patients with celiac disease, an autoimmune disorder of the intestine caused by an allergy to gluten [75].…”

Section: Galectin-10mentioning

confidence: 96%

Towards molecular mechanisms regulating the expression of galectins in cancer cells under microenvironmental stress conditions

Timoshenko

2015

Cell. Mol. Life Sci.

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Galectins, a family of soluble β-galactoside-binding proteins, serve as mediators of fundamental biological processes, such as cell growth, differentiation, adhesion, migration, survival, and death. The purpose of this review is to summarize the current knowledge regarding the ways in which the expression of individual galectins differs in normal and transformed human cells exposed to various stimuli mimicking physiological and pathological microenvironmental stress conditions. A conceptual point is being made and grounded that the modulation of galectin expression profiles is a key aspect of cellular stress responses. Moreover, this modulation might be precisely regulated at transcriptional and post-transcriptional levels in the context of non-overlapping transcription factors and miRNAs specific to galectins.

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“…Taking into account that the ASRD is a clinical syndrome associated with severe and chronic inflammation in both upper and lower airways and a recent finding [10], where the authors reported an overexpression of galectin-10 mRNA in peripheral blood of aspirin-induced asthma, we thought it was interesting to investigate whether galectin-10 was released in the nasal lavage fluid of a group of patients with ASRD before and after the challenge with the triggering agent (L-ASA) and to analyze its probable participation in the associated inflammatory process in ASRD.…”

Section: Introductionmentioning

confidence: 99%

Galectin-10 Is Released in the Nasal Lavage Fluid of Patients with Aspirin-Sensitive Respiratory Disease

Negrete-Garcia

Jiménez-Torres

Alvarado-Vásquez

et al. 2012

The Scientific World Journal

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The aim of this work was to determine the presence of galectin-10 in nasal lavage fluid (NLF) of patients with aspirin-sensitive respiratory disease (ASRD) before and after challenge with L-ASA (aspirin) by ELISA. Fifteen ASRD patients, ten aspirin-tolerant asthmatics (ATA), and fifteen healthy controls (HC) were studied. The baseline presence of Galectin-10 in PBMC was determined using real time PCR. Galectin-10 was evaluated in tissue of nasal polyps by western blot. Our results showed a lower expression in PBMC of ASRD patients than in ATA and healthy controls. However, a higher concentration of galectin-10 in NLF was found in ASRD patients before and after L-ASA challenge; western blot confirmed a high expression of galectin-10 in tissue from nasal polyps obtained from ASRD patients. Our results suggest a probable role of galectin-10 in the inflammatory response observed in ASRD patients; however, confirmatory studies are needed.

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Galectin‐10 mRNA is overexpressed in peripheral blood of aspirin‐induced asthma

Cited by 45 publications

References 41 publications

Diagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma

Diagnostic Value of Clinical Parameters in the Prediction of Aspirin-Exacerbated Respiratory Disease in Asthma

Towards molecular mechanisms regulating the expression of galectins in cancer cells under microenvironmental stress conditions

Galectin-10 Is Released in the Nasal Lavage Fluid of Patients with Aspirin-Sensitive Respiratory Disease

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