Galantamine attenuates the heroin seeking behaviors induced by cues after prolonged withdrawal in rats

Liu, Huifen; Lai, Ming-Kuen; Zhou, Xin; Zhu, Huaqiang; Liu, Yu; Sun, Anna; Ma, Baomiao; Zhang, Fuqiang; Zhou, Wenhua

doi:10.1016/j.neuropharm.2012.01.031

Cited by 22 publications

(13 citation statements)

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“…Each response in the active hole was immediately reinforced with an infusion of heroin (0.1 mg per kg for d 1-2, 0.05 mg per kg for d 3-6, and 0.025 mg per kg for d 7-14) prepared in 0.9% sterile saline, which was administered via the pump over 4 s as previously described [25] . The delivery of each heroin infusion was accompanied by a light cue and was followed by a 20 s time out period, during which responses on the active nose-poke were counted but resulted in no heroin delivery.…”

Section: Heroin Self Administration Training and Withdrawalmentioning

confidence: 99%

“…The rats were anesthetized with sodium pentobarbital (50 mg per kg, ip; Serva, Germany) and then prepared and implanted with intravenous catheters in the right jugular vein as previously described [25] . The intracranial guide cannulas were implanted bilaterally to terminate 2 mm above the NAc shell (from bregma: anterior/posterior, +1.7 mm; medial/lateral, ±0.8 mm; dorsal/ventral, -6.5 mm from dura), the NAc core (from bregma: anterior/posterior, +1.7 mm; medial/lateral, ±2.2 mm; dorsal/ventral, -5.5 mm from dura) or the striatum (from bregma: anterior/posterior, +1.7 mm; medial/lateral, ±2.5 mm; dorsal/ventral, -5.0 mm from dura) according to the atlas of Paxinos and Watson using a stereotaxic frame; operations were performed as previously described [26] .…”

Section: Intravenous Catheterization and Intracranial Cannula Implantmentioning

confidence: 99%

“…After 1 h of habituation in the chamber, the rats (n=6 per group) were microinfused with MPEP in the NAc shell or core. The horizontal locomotion activities were recorded for 1 h. The primary parameter was total distance traveled during the separate 1 h session; data were analyzed as the measure of locomotion using MED Associates SOF-811 Open-field Activity Software [25] . …”

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Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

et al. 2014

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Aim: Glutamatergic neurotransmission in the nucleus accumbens (NAc) is crucial for the relapse to heroin seeking. The aim of this study was to determine whether mGluR5 in the NAc core or shell involved in heroin seeking behavior in rats. Methods: Male SD rats were self-administered heroin under a fixed-ratio 1 (FR1) reinforcement schedule for 14 d, and subsequently withdrawn for 2 weeks. The selective mGluR5 antagonist 2-methyl-6-phenylethynyl-pyridine (MPEP, 5, 15 and 50 nmol per side) was then microinjected into the NAc core or shell 10 min before a heroin-seeking test induced by context, cues or heroin priming. Results: Microinjection of MPEP into the NAc shell dose-dependently decreased the heroin seeking induced by context, cues or heroin priming. In contrast, microinjection of MPEP into the NAc core did not alter the heroin seeking induced by cues or heroin priming. In addition, microinjection with MPEP (15 nmol per side) in the NAc shell reversed both the percentage of open arms entries (OE%) and the percentage of time spent in open arms (OT%) after heroin withdrawal. Microinjection of MPEP (50 nmol per side) in the striatum as a control location did not affect the heroin seeking behavior. Microinjection of MPEP in the 3 locations did not change the locomotion activities. Conclusion: Blockade of mGluR5 in NAc shell in rats specifically suppresses the relapse to heroin-seeking and anxiety-like behavior, suggesting that mGluR5 antagonists may be a potential candidate for the therapy of heroin addiction.Keywords: heroin; addiction; relapse; mGluR5; MPEP; the nucleus accumbens; striatum Acta Pharmacologica Sinica (2014Sinica ( ) 35: 1485Sinica ( -1492 doi: 10.1038/aps.2014 published online Nov 17 2014 Original Article IntroductionRelapse is the most important manifestation of heroin addiction following prolonged periods of abstinence [1] . Relapse arises from intense craving that can be triggered by a single drug-taking experience or exposure to an environmental stimulus [2] . The pre-clinical literature indicates that longterm drug-induced alterations in glutamatergic transmission within the NAc may underlie relapse to drug-seeking behavior following the re-exposure to drugs and drugassociated stimuli during abstinence of the drug [3,4] . Type 5 metabotropic glutamate receptor (mGluR5) as a postsynaptic element is abundantly present throughout in the NAc, where it is positively coupled to NMDA receptor function and mediates various forms of synaptic plasticity [5,6] . The deletion of mGluR5 results in marked deficits in responding to the reinforcing and locomotor stimulating effects of cocaine [7] . Furthermore, the administration of the noncompetitive selective mGluR5 antagonist 2-methyl-6 (phenyethynyl) pyridine (MPEP) decreased the self-administration and/or relapse of nicotine [8,9] , cocaine [10,11] , ethanol [12][13][14] , and heroin [15,16] . MTEP, another antagonist of mGluR5, also can attenuate opiate selfadministration and opiate-seeking behavior in mice [17] . These data indicate mGluR5 plays a...

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Section: Heroin Self Administration Training and Withdrawalmentioning

confidence: 99%

Section: Intravenous Catheterization and Intracranial Cannula Implantmentioning

confidence: 99%

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Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

et al. 2014

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“…Что касается соб-ственно нейробиологических механизмов, то было уста-новлено [6], что в развитии героиновой наркомании важ-ную роль играет нарушение ацетилхолинергической трансмиссии в вентральной тегментальной области и nucleus accumbens. Предполагается также, что при злоупо-треблении героином в патологический процесс вовлека-ются прежде всего вентральный стриатум и префронталь-ная кора, дофаминергическая система, в которой дис-кретно распределены К-опиатные рецепторы [7].…”

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“…Добавим, что введение галантамина эксперименталь-ным животным с зависимостью от героина в дозе 3 мг/кг оказывало благоприятный эффект в виде блокирования связанного с героином поискового поведения [7]. Счита-ют, что эффект галантамина достигается не только за счет увеличения уровня ацетилхолина в ткани головного моз-га, но и тем, что галантамин является позитивным алло-стерическим модулятором имеющих отношение к когни-тивным функциям никотиновых рецепторов.…”

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Cognitive impairments in psychoactive drug addicts

Чухловина

2015

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Role of Opioid Receptors in the Reinstatement of Opioid-Seeking Behavior: An Overview

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Antinori

et al. 2014

Methods in Molecular Biology

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Opioid abuse in humans is characterized by discontinuous periods of drug use and abstinence. With time, the probability of falling into renewed drug consumption becomes particularly high and constitutes a considerable problem in the management of heroin addicts. The major problem in the treatment of opioid dependence still remains the occurrence of relapse, to which stressful life events, renewed use of heroin, and exposure to drug-associated environmental cues are all positively correlated. To study the neurobiology of relapse, many research groups currently use the reinstatement animal model, which greatly contributed to disentangle the mechanisms underlying relapse to drug-seeking in laboratory animals. The use of this model is becoming increasingly popular worldwide, and new versions have been recently developed to better appreciate the differential contribution of each opioid receptor subtype to the relapse phenomenon. In this chapter we review the state of the art of our knowledge on the specific role of the opioid receptors as unrevealed by the reinstatement animal model of opioid-seeking behavior.

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Galantamine attenuates the heroin seeking behaviors induced by cues after prolonged withdrawal in rats

Cited by 22 publications

References 37 publications

Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

Blockade of mGluR5 in the nucleus accumbens shell but not core attenuates heroin seeking behavior in rats

Cognitive impairments in psychoactive drug addicts

Role of Opioid Receptors in the Reinstatement of Opioid-Seeking Behavior: An Overview

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