Galantamine as a Treatment Option for Nicotine Addiction

Jamali, Qutub

doi:10.1155/2021/9975811

Cited by 6 publications

(3 citation statements)

References 12 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…64,65 The potential therapeutic utility of anti-inflammatory and blood glucose lowering medications was also suggested by our analyses, in addition to an anti-Parkinson medication known to interact with dopaminergic activity (i.e., biperiden) and one that acts both as an antagonist of acetylcholinesterase and an agonist of nicotinic receptors (i.e., galantamine), as shown in recent independent studies. 65,66 Although, to date, no repurposed drugs have been developed for treating SUDs based on GWAS data, this is an important potential path forward, particularly for SUDs, where few effective pharmacotherapies are available.…”

Section: Discussionmentioning

confidence: 99%

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Toikumo

Jennings

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factors influence smoking behaviors, and although strides have been made using genome-wide association studies (GWAS) to identify risk variants, the majority of variants identified have been for nicotine consumption, rather than TUD. We leveraged five biobanks to perform a multi-ancestral meta-analysis of TUD (derived via electronic health records, EHR) in 898,680 individuals (739,895 European, 114,420 African American, 44,365 Latin American). We identified 72 independent risk loci; integration with functional genomic tools uncovered 330 potential risk genes, primarily expressed in the brain. TUD was genetically correlated with smoking and psychiatric traits from traditionally ascertained cohorts, externalizing behaviors in children, and hundreds of medical outcomes, including HIV infection, heart disease, and pain. This work furthers our biological understanding of TUD and establishes EHR as a source of phenotypic information for studying the genetics of TUD.

show abstract

Section: Discussionmentioning

confidence: 99%

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Toikumo

Jennings

Pham

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Smoking also increases the risk of tuberculosis, certain eye diseases, and autoimmune system diseases such as rheumatoid arthritis [41,42]. Delayed coronary healing Hypertension Tachycardia Smoke-associated dryness [34][35][36] Despite the availability of current treatment options, such as behavioral therapy and medication-assisted treatment, they are often ineffective for addressing the underlying mechanisms of addiction [37,38]. These treatments typically involve behavioral therapies, medications, and support groups, but they do not address the underlying neurobiological mechanisms of addiction.…”

Section: General Effects Of Addiction On the Bodymentioning

confidence: 99%

Tryptophan and Substance Abuse: Mechanisms and Impact

Davidson

Rashidi

Hossain

et al. 2023

IJMS

View full text Add to dashboard Cite

Addiction, the continuous misuse of addictive material, causes long-term dysfunction in the neurological system. It substantially affects the control strength of reward, memory, and motivation. Addictive substances (alcohol, marijuana, caffeine, heroin, methamphetamine (METH), and nicotine) are highly active central nervous stimulants. Addiction leads to severe health issues, including cardiovascular diseases, serious infections, and pulmonary/dental diseases. Drug dependence may result in unfavorable cognitive impairments that can continue during abstinence and negatively influence recovery performance. Although addiction is a critical global health challenge with numerous consequences and complications, currently, there are no efficient options for treating drug addiction, particularly METH. Currently, novel treatment approaches such as psychological contingency management, cognitive behavioral therapy, and motivational enhancement strategies are of great interest. Herein, we evaluate the devastating impacts of different addictive substances/drugs on users′ mental health and the role of tryptophan in alleviating unfavorable side effects. The tryptophan metabolites in the mammalian brain and their potential to treat compulsive abuse of addictive substances are investigated by assessing the functional effects of addictive substances on tryptophan. Future perspectives on developing promising modalities to treat addiction and the role of tryptophan and its metabolites to alleviate drug dependency are discussed.

show abstract

“…Not supervising, approximately 66% of Australian smokers are classified as unsuccessful quitters ( 6 ). In 2019, the prevalence rate of smoking was 14.5% among the general adult population, which was 26.8% among adults with mental illness ( 7 ). The higher smoking rate among individuals with mental illness is unclear ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of exercise with nicotine replacement therapy for smoking cessation in adults: A systematic review

et al. 2022

View full text Add to dashboard Cite

ObjectiveThis systematic review aimed to evaluate the efficacy of exercise programmes with nicotine replacement therapy (NRT) for smoking cessation in adults.IntroductionNicotine addiction is mediated by dopamine. Exercise can also activate the dopamine reward system. Therefore, exercise may effectively facilitate NRT to reduce cigarette cravings and withdrawal symptoms.Inclusion criteriaClinical trials between 2000 and 2022 used exercise protocols of any intensity for smoking cessation, in current smokers or recent quitters of both genders, aged 18–70, without severe diseases and pregnancy. Mental disorders were not excluded, as exercise can improve mental health status. Therefore, it may be as effective among people with mental health issues as the general population in preventing nicotine cravings and supporting abstinence.MethodsFour databases (PubMed, Embase, Cochrane, and Medline) were searched for papers in English using the terms “nicotine replacement therapy’, “exercise,” and “smoking cessation.” Titles and abstracts were screened for potentially eligibility before full texts were reviewed. Sample size, gender, study duration, and age was then extracted. The certainty of the evidence was assessed using Joanna Briggs Institute’s (JBI’s) GRADE approach.ResultsSeventeen studies were identified with a total of 3,191 participants. Three studies are not a randomised control study. There was moderate-high quality evidence that exercise can aid NRT in promoting smoking cessation in the short term. Several studies reported temporary reductions in cravings; however, only one trial reported a decrease in cigarette consumption due to exercise intervention and one demonstrated increased smoking abstinence at 1 year of the intervention.ConclusionExercise with NRT aids smoking cessation in the short term, but no evidence suggests its efficacy in the long term when combined. Future trials should include larger sample sizes and strategies to increase exercise adherence.

show abstract

Galantamine as a Treatment Option for Nicotine Addiction

Cited by 6 publications

References 12 publications

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Multi-ancestry meta-analysis of tobacco use disorder prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Tryptophan and Substance Abuse: Mechanisms and Impact

The effects of exercise with nicotine replacement therapy for smoking cessation in adults: A systematic review

Contact Info

Product

Resources

About