Galanin is Co‐Expressed with Substance P, Calbindin and Corticotropin‐Releasing Factor (<scp>CRF</scp>) in The Enteric Nervous System of the Wild Boar (<i>Sus scrofa</i>) Small Intestine

Czujkowska, Agnieszka; Arciszewski, Marcin B.

doi:10.1111/ahe.12179

Cited by 6 publications

(2 citation statements)

References 40 publications

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“…Other substances observed during the present study in SP-positive neurons supplying the stomach may also show activities similar to actions of substance P. Namely, GAL takes part in the regulation of intestinal motility. The influence of GAL on the intestinal muscles may result in stimulatory or inhibitory effects depending on animal species and the intestinal fragment [36][37][38]. Similar situations have been described in the case of SP [39,40].…”

Section: Discussionmentioning

confidence: 98%

Aspirin Administration Affects Neurochemical Characterization of Substance P-Like Immunoreactive (SP-LI) Nodose Ganglia Neurons Supplying the Porcine Stomach

Rytel

Całka

2020

BioMed Research International

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Background. Acetylsalicylic acid (ASA) is a commonly used anti-inflammatory, antipyretic, and analgesic drug, which has many side effects on the gastric mucosal layer. Despite this, knowledge concerning the influence of ASA on neuronal cells supplying the stomach is very scanty. Methods. This investigation was performed on ten immature gilts of the Large White Polish race divided into two groups (five animals in each): a control group and animals which were treated with ASA. The retrograde neuronal tracer Fast Blue (FB) was injected into the prepyloric region of the stomach in all animals. ASA was then given orally to the experimental (ASA) group of gilts from the seventh day after FB injection to the 27th day of the experiment. After this period, all animals were euthanized. Immediately after euthanasia, nodose ganglia (NG) were collected and subjected to a standard double-labelling immunofluorescence technique using antibodies directed toward substance P (SP) and other selected neuronal factors, such as galanin (GAL), neuronal isoform of nitric oxide synthase (nNOS), vasoactive intestinal polypeptide (VIP), and calcitonin gene-related peptide (CGRP). Key Results. The obtained results show that SP-LI neurons located in NG supplying the porcine stomach were also immunoreactive to all the above-mentioned neuronal factors. Moreover, ASA administration caused an increase in the degree of colocalization of SP with other neuronal active substances, and the most visible changes concerned the number of neurons simultaneously immunoreactive to SP and CGRP. Conclusions and Inferences. These observations indicate that the population of SP-LI neurons supplying the stomach is not homogeneous and may undergo changes after ASA administration. These changes are probably connected with inflammatory processes and/or neuroprotective reactions although their exact mechanisms remain unknown.

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Section: Discussionmentioning

confidence: 98%

Aspirin Administration Affects Neurochemical Characterization of Substance P-Like Immunoreactive (SP-LI) Nodose Ganglia Neurons Supplying the Porcine Stomach

Rytel

Całka

2020

BioMed Research International

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“…Galanin (GAL) is a brain-gut neuropeptide widely distributed in the POA, MBH, and pituitary stalk-median eminence of the cyclic gilt ( Czujkowska and Arciszewski 2016 ). The anorexigenic neuropeptide GAL expression and immunoreactivity are regulated by Estrogen ( Spergel 2019 ).…”

Section: Neuropeptide Modulators Of Gnrh Neuronal Activity Gnrh Secretion and Reproduction That Act Directly On Gnrh Neuronsmentioning

confidence: 99%

The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

et al. 2021

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Within the hypothalamic-pituitary-gonad (HPG) axis, the major hierarchical component is gonadotropin-releasing hormone (GnRH) neurons, which directly or indirectly receive regulatory inputs from a wide array of regulatory signals and pathways, involving numerous circulating hormones, neuropeptides, and neurotransmitters, and which operate as a final output for the brain control of reproduction. In recent years, there has been an increasing interest in neuropeptides that have the potential to stimulate or inhibit GnRH in the hypothalamus of pigs. Among them, Kisspeptin is a key component in the precise regulation of GnRH neuron secretion activity. Besides, other neuropeptides, including neurokinin B (NKB), neuromedin B (NMB), neuromedin S (NMS), α-melanocyte-stimulating hormone (α-MSH), Phoenixin (PNX), show potential for having a stimulating effect on GnRH neurons. On the contrary, RFamide-related peptide-3 (RFRP-3), endogenous opioid peptides (EOP), neuropeptide Y (NPY), and Galanin (GAL) may play an inhibitory role in the regulation of porcine reproductive nerves and may directly or indirectly regulate GnRH neurons. By combining data from suitable model species and pigs, we aim to provide a comprehensive summary of our current understanding of the neuropeptides acting on GnRH neurons, with a particular focus on their central regulatory pathways and underlying molecular basis.

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Long-term treatment with naproxen changes the chemical coding of the porcine intramural duodenum neurons

Czajkowska

Rychlik

Całka

2020

Annals of Anatomy - Anatomischer Anzeiger

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Galanin is Co‐Expressed with Substance P, Calbindin and Corticotropin‐Releasing Factor (CRF) in The Enteric Nervous System of the Wild Boar (Sus scrofa) Small Intestine

Cited by 6 publications

References 40 publications

Aspirin Administration Affects Neurochemical Characterization of Substance P-Like Immunoreactive (SP-LI) Nodose Ganglia Neurons Supplying the Porcine Stomach

Aspirin Administration Affects Neurochemical Characterization of Substance P-Like Immunoreactive (SP-LI) Nodose Ganglia Neurons Supplying the Porcine Stomach

The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

Long-term treatment with naproxen changes the chemical coding of the porcine intramural duodenum neurons

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