The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

Shuang, Zhao; Guo, Zhanbao; Wei, Xu; Wang, Pingqing

doi:10.1590/1984-3143-ar2021-0063

Cited by 5 publications

(3 citation statements)

References 105 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuromedin S ( NMS ) and cocaine- and amphetamine-regulated transcripts ( CARTPT ) are two neuropeptides that are widely distributed in the central nervous system (CNS). Although their roles in avian egg production are not clear, they have been shown to participate in signal transduction pathways in estrogenic feedback regulation on the HPO axis in mammals [ 27 , 28 ]. Our study thus suggests that NMS and CARTPT might play similar roles in chicken.…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of hypothalamus and pituitary tissues reveals genetic mechanisms associated with high egg production rates in Changshun green-shell laying hens

Xu,

Mu,

Gegen

et al. 2023

BMC Genomics

View full text Add to dashboard Cite

Background Changshun green-shell laying hens are unique to the Guizhou Province, China, and have high egg quality but relatively low yield. Egg production traits are regulated by the hypothalamus-pituitary-ovary axis. However, the underlying mechanism remains unclear. Thus, we conducted RNA sequencing of hypothalamic and pituitary tissues from low- and high-yielding Changshun green-shell laying hens to identify critical pathways and candidate genes involved in controlling the egg production rate. Results More than 39 million clean reads per sample were obtained, and more than 82% were mapped to the Gallus gallus genome. Further analysis identified 1,817 and 1,171 differentially expressed genes (DEGs) in the hypothalamus and pituitary, respectively. Nineteen DEGs were upregulated in both the hypothalamus and pituitary of high-yielding chickens. The functions of these DEGs were mainly associated with ion transport or signal transduction. Gene set enrichment analysis revealed that the pathways enriched in the hypothalamus were mainly associated with gonadotropin-releasing hormone (GnRH) secretion, neurotransmitter release, and circadian rhythms. The pathways enriched in the pituitary were mainly associated with GnRH secretion, energy metabolism, and signal transduction. Five and four DEGs in the hypothalamus and pituitary, respectively, were selected randomly for qRT-PCR analysis. The expression trends determined via qRT-PCR were consistent with the RNA-seq results. Conclusions The current study identified 19 DEGs upregulated in both the hypothalamus and pituitary gland, which could provide an important reference for further studies on the molecular mechanisms underlying egg production in Changshun green-shell laying hens. In addition, enrichment analysis showed that GnRH secretion and signal transduction, especially neurotransmitter release, play crucial roles in the regulation of egg production.

show abstract

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis of hypothalamus and pituitary tissues reveals genetic mechanisms associated with high egg production rates in Changshun green-shell laying hens

Xu,

Mu,

Gegen

et al. 2023

BMC Genomics

View full text Add to dashboard Cite

show abstract

“…Several unrelated studies suggest a new role for NMB as a stimulatory peptide of the hypothalamic-pituitary-gonadal (HPG) axis, which is likely mediated via the hypothalamic gonadotropin-releasing hormone [47][48][49]. Recently, NMB was also reported to be involved in the pathogenesis of vascular smooth muscle cell calcification through the modulation of high phosphate-induced calcification [50].…”

Section: Gastrin-releasing Peptide (Grp)mentioning

confidence: 99%

Bombesins: A New Frontier in Hybrid Compound Development

Serafin,

Kleczkowska

2023

Pharmaceutics

View full text Add to dashboard Cite

Recently, bombesin (BN) and its analogs have attracted much attention as excellent anticancer agents because they interact with specific receptors widely distributed on the surface of various cancer cells. However, their biological properties proceed far beyond this, given a broad spectrum of activity. Bombesin receptor ligands are effective drugs for the treatment of rheumatoid arthritis or gastrointestinal diseases. However, most diseases are complex, and the use of polytherapy may lead to pharmacokinetic and pharmacodynamic drug–drug interactions, resulting in side effects. Therefore, there is a need to develop effective compounds that also contain BN or its analogs, which are combined with other structural entities, thus generating a so-called hybrid drug. Hybrid drugs that contain bombesin pharmacophore(s) may be proposed as a solution to the problem of polytherapy or the lack of an effective cure. Such structures have now demonstrated the desired efficacy, though information on these aforementioned compounds is relatively scarce. Therefore, our paper aims to encourage researchers to focus on bombesins. Herein, we indicate that the hybrid approach should also be firmly applied to bombesins and the BN receptor family. This paper’s structure is divided into two main sections demonstrating bombesins and their properties, as well as recent data on bombesin-based hybrid compounds and their potential usefulness in medicine. Overall, it refers to the discovery and synthesis of modified bombesin-based hybrid compounds.

show abstract

“…These steroids, in turn, provide feedback to the brain to complete the HPG axis and regulate the reproductive cycle. Thus, hypothalamic gonadotropin-releasing hormone (GnRH) is considered as the key player in the regulation of reproduction in mammals (Evans & Anderson 2017, Zhao et al 2021.…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals

Fan

Shuang

Wang

et al. 2023

Journal of Endocrinology

View full text Add to dashboard Cite

Reproduction in mammals is an extremely energy-intensive process and is therefore tightly controlled by the body's energy status. Changes in the nutritional status of the body cause fluctuations in the levels of peripheral metabolic hormone signals, such as leptin, insulin, and ghrelin, which provide feedback to the hypothalamus and integrate to coordinate metabolism and fertility. Therefore, to link energy and reproduction, energetic information must be centrally transmitted to Gonadotropin-releasing hormone (GnRN) neurons that act as reproductive gating. However, GnRH neurons themselves are rarely directly involved in energy information perception. Firstly, as key factors in the control of GnRH neurons, we describe the direct role of Kisspeptin and Arg-Phe amide-related peptide-3(RFRP-3) neurons in mediating metabolic signaling. Secondly, we focused on summarizing the roles of metabolic hormone-sensitive neurons in mediating peripheral energy hormone signaling. Some of these hormone-sensitive neurons can directly transmit energy information to GnRH neurons, such as Orexin neurons, etc., while others act indirectly through other neurons such as Kisspeptin and RFRP-3 neuron, such as (Pituitary adenylate cyclase-activating polypeptide)PACAP neurons, etc. In addition, as another important aspect of the integration of metabolism and reproduction, the impact of reproductive signaling itself on metabolic function were also considered, as exemplified by our examination of the role of Kisspeptin and RFRP-3 in feeding control. This review summarizes the latest research progress in related fields, in order to more fully understand the central neuropeptide network that integrates energy metabolism and reproduction.

show abstract

The neuroendocrine pathways and mechanisms for the control of the reproduction in female pigs

Cited by 5 publications

References 105 publications

Transcriptome analysis of hypothalamus and pituitary tissues reveals genetic mechanisms associated with high egg production rates in Changshun green-shell laying hens

Transcriptome analysis of hypothalamus and pituitary tissues reveals genetic mechanisms associated with high egg production rates in Changshun green-shell laying hens

Bombesins: A New Frontier in Hybrid Compound Development

Hypothalamic neuroendocrine integration of reproduction and metabolism in mammals

Contact Info

Product

Resources

About