Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo

Zhu, Liping; Luo, Qiang; Bi, Jianjun; Ding, Jieying; Ge, Shengfang; Chen, Fuxiang

doi:10.1016/j.cbi.2014.10.027

Cited by 46 publications

(34 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may explain why galangin inhibits the proliferation of osteosarcoma cells. Similarly, a previous study reported that galangin induces significant cell cycle arrest of the human head and neck squamous carcinoma cells at the G0/G1 phase, with decreased expression of cyclin D1 (16), indicating that galangin mediates the cell cycle through the PI3K/Akt/ cyclin D1 signaling pathway.…”

Section: Discussionsupporting

confidence: 63%

“…Currently, it is in focus for its antitumor property. Studies have shown that galangin suppresses the proliferation and functions of various tumor cells, including renal carcinoma Caki cells (13), hepatocellular carcinoma (14), fibrosarcoma (15), and squamous carcinoma (16). However, the effects of galangin on osteosarcoma are still not clear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Yang

Han

et al. 2016

Oncology Reports

View full text Add to dashboard Cite

Osteosarcoma is the most common malignant bone tumor that frequently affects adolescents. Osteosarcoma cells tend to proliferate and invade other tissues such as those of the lungs. Currently, neoadjuvant chemotherapy is the primary strategy to prevent tumor progression. However, its adverse effects result in poor long-term outcomes. Previous research has shown that galangin exhibits antitumor properties on several types of cancer cells; however its effect on osteosarcoma cells is yet unknown. The aims of this study were to evaluate the effects of galangin on the proliferation, apoptosis, migration, and invasion of osteosarcoma cells and to explore the underlying mechanisms. We found that the proliferation of MG63 and U20S osteosarcoma cells decreased significantly, while the apoptosis of MG63 cells accelerated significantly after exposure to galangin. In addition, the migration and invasion of MG63 cells were significantly inhibited by galangin. Moreover, phosphoinositide 3-kinase (PI3K) and Aktp-Thr308 expression levels were found to be significantly lower in galangin-treated MG63 cells than in the control cells, and the protein expression levels of their downstream regulators cyclin D1 and matrix metalloproteinase 2/9 were also downregulated in galangin-treated groups, while those of p27Kip1, caspase-3, and caspase-8 were upregulated. These findings suggest that galangin suppresses osteosarcoma cells by inhibiting their proliferation and invasion and accelerating their apoptosis, and the mechanism may be associated with the inhibition of PI3K and its downstream signaling pathway.

show abstract

Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Yang

Han

et al. 2016

Oncology Reports

View full text Add to dashboard Cite

show abstract

“…It is the active constituent of the rhizome of the Alpinia galanga plant, which belongs to the Zingiberaceae family [34]. Galangin has been proven to have various pharmacological effects [35], such as antimicrobial activity [36], anticancer [37], anti-inflammatory [38], antioxidative [39], metabolic enzyme modulation [40], and antiobesity [41] effects. Moreover, galangin was found to produce a significant decrease in serum lipids [42].…”

Section: Discussionmentioning

confidence: 99%

Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats

Sayed

Ahmed

El-Shehawi

et al. 2020

Foods

View full text Add to dashboard Cite

Obesity is a serious global problem that causes predisposition to numerous serious diseases. The current study aims to investigate the effect of ginger water on body weight and energy expenditure through modulation of mRNA expression of carbohydrate and lipid metabolism. A white colored liquid obtained during freeze-drying of fresh rhizomes of Zingiber officinal was collected and named ginger water. It was used to treat rats, then blood and tissue samples were collected from the liver and white adipose at the end of the experiment. The serum was prepared and used for biochemical assays, while tissue samples were used for RNA isolation and gene expression analysis via Reverse transcription polymerase chain reaction (RT-PCR). Results of High Performance Liquid Chromatography (HPLC) analysis of ginger water revealed the presence of chrysin and galangin at concentrations of 0.24 µg/mL and 0.53 µg/mL, respectively. Average body weight gain decreased significantly in groups that received ginger water. In addition, both total cholesterol and serum triacylglycerol were reduced in the groups that received ginger water. Furthermore, mRNA expression of Sterol regulatory element-binding protein 1 (SREBP-1c) in the liver and leptin in adipose tissues were downregulated, while those of adiponectin, hepatic carnitine palmitoyltransferase1 (CPT-1), acyl-coA oxidase (ACO), Glucose transporter 2 (GLUT-2), and pyruvate kinase (PK) were upregulated in ginger water-treated groups. These results clearly revealed the lowering body weight gain effect of ginger water, which most likely occurs at the transcriptional level of energy metabolizing proteins.

show abstract

“…[57] Galangin, compound 5, a flavonol of flavonoids, appears to be the predominant constituent in all parts of A. officinarum – leaves, aerial parts, and rhizomes, showing anti-inflammatory, antioxidant, and anticancer properties, as well as the inhibition of NO production and enzymes. [323334394758717273] There have been much studies on the compound galangin;[7475767778798081] however, its molecular mechanism is still unknown. It has been reported that flavonoids and terpenes act by inhibiting the cytoplasmic membrane functions, such as altering the influx of calcium, hence promoting the disruption of the cellular membrane.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Basri¹,

Taha²,

Ahmad³

2017

Phcog Rev

View full text Add to dashboard Cite

The rhizomes of Alpinia officinarum Hance have been used conventionally for the treatment of various ailments, triggering a wide interest from the scientific research community on this ethnomedicinal plant. This review summarizes the phytochemical and pharmacological properties of the extracts and fractions from A. officinarum, a plant species of the Zingiberaceae family. Different parts of the plant – leaves, roots, rhizomes, and aerial parts – have been extracted in various solvents – methanol, ethanol, ethyl acetate, hexane, dichloromethane, aqueous, chloroform, and petroleum ether, using various techniques – Soxhlet extraction, maceration, ultrasonication, and soaking, whereas fractionation of the plant extracts involves the solvent–solvent partition method. The extracts, fractions, and isolated compounds have been studied for their biological activities – antioxidant, antibacterial, anti-inflammatory, anticancer, antiproliferative, inhibition of enzymes, as well as the inhibition of nitric oxide production. More findings on A. officinarum are certainly important to further develop potential bioactive drug compounds.

show abstract

Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo

Cited by 46 publications

References 36 publications

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Galangin suppresses human osteosarcoma cells: An exploration of its underlying mechanism

Ginger Water Reduces Body Weight Gain and Improves Energy Expenditure in Rats

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Contact Info

Product

Resources

About