Galangin ameliorates cisplatin induced nephrotoxicity in vivo by modulation of oxidative stress, apoptosis and inflammation through interplay of MAPK signaling cascade

Tomar, Ameesha; Vasisth, Swati; Khan, Sana Irfan; Malik, Salma; Nag, Tapas Chandra; Arya, Dharamvir Singh; Bhatia, Jagriti

doi:10.1016/j.phymed.2017.05.007

Cited by 64 publications

(41 citation statements)

References 32 publications

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“…In the CP-related apoptosis; propolis and NP applications increased the release of Bcl-2 protein and decreased the release of Bax protein. In a study, in which galangin was used to prevent the renal tubular damage induced by CP in rats [ 67 ], it was determined that CP increased the expression of Bax, which is a proapoptotic protein, and decreased the expression of Bcl-2, which is an antiapoptotic protein. On the other hand, the use of galangin reversed that situation.…”

Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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This study was performed to determine the effects of chitosan-coated nano-propolis (NP), which is synthesized via a green sonochemical method, and propolis on the side effects of cisplatin (CP), which is a widely used drug in the treatment of cancer. For this aim, 56 rats were divided into seven groups, balancing their body weights (BW). The study was designed as Control, CP (3 mg/kg BW at single dose of CP as intraperitoneal, ip), Propolis (100 mg/kg BW per day of propolis by gavage), NP-10 (10 mg/kg BW of NP per day by gavage), CP + Propolis (3 mg/kg BW of CP and 100 mg/kg BW of propolis), CP + NP-10 (3 mg/kg CP and 10 mg/kg BW of NP), and CP + NP-30 (3 mg/kg BW of CP and 30 mg/kg BW of NP). Propolis and NP (especially NP-30) were preserved via biochemical parameters, oxidative stress, and activation of apoptotic pathways (anti-apoptotic protein: Bcl-2 and pro-apoptotic protein: Bax) in liver and kidney tissues in the toxicity induced by CP. The NP were more effective than propolis at a dose of 30 mg/kg BW and had the potential to ameliorate CP’s negative effects while overcoming serious side effects such as liver and kidney damage.

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Section: Discussionmentioning

confidence: 99%

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Seven

Karakuş

et al. 2020

Plants

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“…Malik et al observed the use of apigenin ameliorated streptozotocin-induced diabetic nephropathy in rats via preventing the activation of the MAPK pathway, which then inhibited inflammation (reduced TNF-α, IL-6, and NF-κB expression) and apoptosis (increased expression of Bcl-2 and decreased Bax and caspase-3) [32]. Similarly, pretreatment with galangin preserved renal function (normalized serum creatinine and blood urea nitrogen), suppressed oxidative stress (decreased level of malondialdehyde), inflammation (reduced levels of TNF-α and IL-6), and the activation of apoptotic pathways (decreased expression of Bax and caspase-3) by de-phosphorylating p38, JNK, and ERK1/2 proteins [33]. In our study, MAPK11, MAPK15 as well as pro-inflammatory cytokine CCL5 and pro-apoptotic Bax were also found to be significantly upregulated in MN, further verifying the MAPK-mediated inflammation and apoptosis mechanisms for MN.…”

Section: Discussionmentioning

confidence: 99%

Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy

et al. 2019

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BackgroundTo identify noninvasive diagnostic biomarkers for membranous nephropathy (MN).Material/MethodsThe mRNA microarray datasets GSE73953 using peripheral blood mononuclear cells (PBMCs) of 8 membranous nephropathy patients and 2 control patients; and microRNAs (miRNA) microarray dataset GSE64306 using urine sediments of 4 membranous nephropathy patients and 6 control patients were downloaded from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) and differentially expressed miRNAs (DEMs) were respectively identified from PBMCs and urine sediments of membranous nephropathy patients, followed with functional enrichment analysis, protein-protein interaction (PPI) analysis, and miRNA-target gene analysis. Finally, the DEGs and the target genes of DEMs were overlapped to obtain crucial miRNA-mRNA interaction pairs for membranous nephropathy.ResultsA total of 1246 DEGs were identified from PBMCs samples, among them upregulated CCL5 was found to be involved in the chemokine signaling pathway, and BAX was found to be apoptosis related; while downregulated PPM1A and CDK1 were associated with the MAPK signaling pathway and the p53 signaling pathway, respectively. The hub role of CDK1 (degree=18) and CCL5 (degree=12) were confirmed after protein-protein interaction network analysis in which CKD1 could interact with RAB1A. A total of 28 DEMs were identified in urine sediments. The 276 target genes of DEMs were involved in cell cycle arrest (PPM1A) and intracellular signal transduction (BRSK1). Thirteen genes were shared between the DEGs in PMBCs and the target genes of DEMs in urine sediments, but only hsa-miR-192-3p-RAB1A, hsa-miR-195-5p-PPM1A, and hsa-miR-328-5p-BRSK1 were negatively related in their expression level.ConclusionsBoth peripheral blood and urinary miR-195-5p, miR-192-3p, miR-328-5p, and their target genes PPM1A, RAB1A, and BRSK1 may be potential biomarkers for membranous nephropathy by participating in inflammation and apoptosis.

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“…Moreover, multiple underlying pathophysiological mechanisms leads to chronic renal failure [4]. Several factors such as diabetes mellitus [5], hypertension [6], drugs [7], obesity [8], chronic infection [9], sickle cell anaemia [10], smoking [11], environmental toxins [12] and advanced age [13] are involved in the initiation and progression of CKD. Approximately more than three people become diabetic once every 10 seconds or almost ten million new cases reported per year [14, 15].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies

Kpemissi

Eklu-Gadégbéku

Veerapur

et al. 2019

Heliyon

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Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of Combretum micranthum and to carry out chemoprofiling, in-vitro antioxidant and ex-vivo nephroprotective capacity of the title plant. The phytochemical and biological activity survey of C. micranthum has reveals the presence of many bioactive compounds such as flavonoids, terpenoids, steroids and alkaloids with many biological activities. Phytochemical investigation re-confirmed the presence of these compounds. Hydroalcoholic extract of C. micranthum (CM extract) showed a strong antioxidant activity by scavenging AAPH, DPPH, nitric oxide, hydrogen peroxide and chelating metal ions. CM extract exhibited significant ( P < 0.001) dose dependent inhibition of ferric chloride-ascorbic acid induced lipid peroxidation. Diabetic nephropathy is a serious and common complication leading to end stage renal disease. Therefore, in the present study, glucose-induced toxicity was also studied in human embryonic kidney cells (HEK-293) as an in vitro model for diabetic nephropathy. The results showed that exposure of cells to high glucose (100 mM) for 72 h significantly reduced the cell viability resulting in morphological changes such as cell shrinkage, rounded cell shape and cytoplasmic vacuolation. Treatment with CM extract at 10 and 25 μg/mL resulted in significant improvement in cell viability from 10 to 23% compared to the high glucose control. This study demonstrated the potential antioxidant and nephroprotective properties of C. micranthum , justifying its traditional use in the treatment of various diseases.

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Galangin ameliorates cisplatin induced nephrotoxicity in vivo by modulation of oxidative stress, apoptosis and inflammation through interplay of MAPK signaling cascade

Cited by 64 publications

References 32 publications

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Turkish Propolis and Its Nano Form Can Ameliorate the Side Effects of Cisplatin, Which Is a Widely Used Drug in the Treatment of Cancer

Both Peripheral Blood and Urinary miR-195-5p, miR-192-3p, miR-328-5p and Their Target Genes PPM1A, RAB1A and BRSK1 May Be Potential Biomarkers for Membranous Nephropathy

Antioxidant and nephroprotection activities of Combretum micranthum: A phytochemical, in-vitro and ex-vivo studies

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