Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro

Guo, Ava J.Y.; Xie, Heidi Qunhui; Choi, Roy Chi Yan; Zheng, Yuzhong; Bi, Cathy W. C.; Xu, Sherry Li; Dong, Tina Tingxia; Tsim, Karl Wah Keung

doi:10.1016/j.cbi.2010.05.002

Cited by 89 publications

(56 citation statements)

References 9 publications

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“…[57] Galangin, compound 5, a flavonol of flavonoids, appears to be the predominant constituent in all parts of A. officinarum – leaves, aerial parts, and rhizomes, showing anti-inflammatory, antioxidant, and anticancer properties, as well as the inhibition of NO production and enzymes. [323334394758717273] There have been much studies on the compound galangin;[7475767778798081] however, its molecular mechanism is still unknown. It has been reported that flavonoids and terpenes act by inhibiting the cytoplasmic membrane functions, such as altering the influx of calcium, hence promoting the disruption of the cellular membrane.…”

Section: Discussion and Future Directionsmentioning

confidence: 99%

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Basri¹,

Taha²,

Ahmad³

2017

Phcog Rev

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The rhizomes of Alpinia officinarum Hance have been used conventionally for the treatment of various ailments, triggering a wide interest from the scientific research community on this ethnomedicinal plant. This review summarizes the phytochemical and pharmacological properties of the extracts and fractions from A. officinarum, a plant species of the Zingiberaceae family. Different parts of the plant – leaves, roots, rhizomes, and aerial parts – have been extracted in various solvents – methanol, ethanol, ethyl acetate, hexane, dichloromethane, aqueous, chloroform, and petroleum ether, using various techniques – Soxhlet extraction, maceration, ultrasonication, and soaking, whereas fractionation of the plant extracts involves the solvent–solvent partition method. The extracts, fractions, and isolated compounds have been studied for their biological activities – antioxidant, antibacterial, anti-inflammatory, anticancer, antiproliferative, inhibition of enzymes, as well as the inhibition of nitric oxide production. More findings on A. officinarum are certainly important to further develop potential bioactive drug compounds.

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Section: Discussion and Future Directionsmentioning

confidence: 99%

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

Basri¹,

Taha²,

Ahmad³

2017

Phcog Rev

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“…Interestingly, most constituents of Rhizoma Alpiniae Officinarum have been reported to show profound pharmacological effects. For instance, galangin, as one of the major flavonoids in Rhizoma Alpiniae Officinarum , has been demonstrated various biological activities including anti-oxidative, anti-clastogenic, anti-mutagenic, metabolic enzyme modulating and free radical scavenging activity 74, 75 . Besides, it can inhibit the proliferation of human mammary tumor cells by down-regulation of cyclins D3, E and A 74 .…”

Section: Resultsmentioning

confidence: 99%

“…For instance, galangin, as one of the major flavonoids in Rhizoma Alpiniae Officinarum , has been demonstrated various biological activities including anti-oxidative, anti-clastogenic, anti-mutagenic, metabolic enzyme modulating and free radical scavenging activity 74, 75 . Besides, it can inhibit the proliferation of human mammary tumor cells by down-regulation of cyclins D3, E and A 74 . Pinocembrin, another major flavonoid molecule from Rhizoma Alpiniae Officinarum , exhibited estrogenic activity with EC 50 value of 67 μM 75 .…”

Section: Resultsmentioning

confidence: 99%

A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula

Wang

Yang

et al. 2017

Sci Rep

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Traditional Chinese medicine (TCM), such as Uyghur Medicine (UM) has been used in clinical treatment for many years. TCM is featured as multiple targets and complex mechanisms of action, which is normally a combination of medicinal herbs and sometimes even contains certain rare animal medicinal ingredients. A question arises as to whether these animal materials can be removed replaced from TCM applications due to their valuable rare resources or animal ethics. Here, we select a classical UM Yimusake formula, which contains 3 animal drugs and other 8 herbs, and has got wealthy experience and remarkable achievements in treating erectile dysfunction (ED) in China. The active components, drug targets and therapeutic mechanisms have been comprehensively analyzed by systemspharmacology methods. Additionally, to validate the inhibitory effects of all candidate compounds on their related targets, in vitro experiments, computational analysis and molecular dynamics simulations were performed. The results show that the modified, original and three animal materials display very similar mechanisms for an effective treatment of ED, indicating that it is quite possible to remove these three animal drugs from the original formula while still keep its efficiency. This work provides a new attempt for deleting animal materials from TCM, which should be important for optimization of traditional medicines.Traditional Chinese medicine (TCM) including Uyghur Medicine (UM) has been used for pharmaceutical and dietary therapy for several millennia 1 . UM is also characterized as multiple chemical components and multiple targets, which has been acknowledged with remarkable curative effects in treating some complex diseases such as arthritis, rheumatism, chronic back leg pain 2 . Due to these extensive use and the remarkable therapeutic effects, the interest in studying UM is gradually increased nowadays.However, UM often contains not only, as usual as common TCMs, a combination of many medicinal herbs, but also certain animal medicinal materials 3 . Some of these animal taxa like rhino, tiger, or musk beer, etc., are now at the brim of extinction due to commercial overexploitation 4 . Additionally, poaching of animals for their medicinal uses has also brought many wild species under the red data book, for a possibility of their extinction. For instance, bear bile has a decades-long history in the treatment of hepatic and biliary disorders, but it is just due to this extensive consumption of bear bile that has made bears become endangered species 5 . Moreover, the rapid deterioration of the natural biodiversity, as well as the loss and destruction of the habitat have also caused many rare animals in danger of extinction 4 . Due to these reasons, animal species for therapeutic purposes are becoming more and more precious, a question of whether animal ingredients in UM preparations can be removed arises, due to the current limitations of experimental approaches and the complex function mechanism of "multiple components, multiple targets" of...

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“…Naturally derived AchE inhibitors are also a promising area of interest (28). Amongst numerous examples of drugs originating from plants that act as an AchE inhibitors are huperzine A and B (lycopodium alkaloid isolated from Huperzia serrate ) (293031), galangin (flavonoid isolated from Rhizoma Alpiniae Officinarum ) (32), and also Himatanthus lancifolius extract (33). …”

Section: Introductionmentioning

confidence: 99%

Cognitive enhancing of pineapple extract and juice in scopolamine-induced amnesia in mice

et al. 2017

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The objective of the present study was to evaluate the cognitive enhancing of pineapple juice and ethanolic extract in scopolamine-induced cognitive deficit mice. The ethanolic extract of pineapple (Ananas comosus (L.) Merr.) was prepared by maceration method and its juice was obtained by a homogenizer. Object recognition task was used to evaluate the mice memory. Exploration time in the first and second trial was recorded. The differences in exploration time between a familiar and a novel object in the second trial were taken as a memory index. Animals were randomly assigned into 15 groups of 6 each including: control group (normal saline + vehicle), positive control group (scopolamine + rivastigmine), seven experimental groups (received scopolamine alone or scopolamine + ethanolic extract of pineapple in different doses), six other experimental groups were treated by ethanolic extract or juice of pineapple in different doses. Scopolamine (100 μL, 1 mg/kg, i.p.) and pineapple juice or extract (50, 75 and 100 mg/kg, i.p.) were administered 40 and 30 min before starting the second trial in the experimental groups. Object discrimination was impaired after scopolamine administration. Results showed that juice and ethanolic extract of pineapple significantly restored object recognition ability in mice treated with scopolamine. These finding suggested that pineapple had a protective role against scopolamine-induced amnesia, indicating its ability in management of cognitive disorders.

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Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro

Cited by 89 publications

References 9 publications

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

A review on the pharmacological activities and phytochemicals of Alpinia officinarum (Galangal) extracts derived from bioassay-guided fractionation and isolation

A New Strategy for Deleting Animal drugs from Traditional Chinese Medicines based on Modified Yimusake Formula

Cognitive enhancing of pineapple extract and juice in scopolamine-induced amnesia in mice

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