Galactosylated chitosan-modified ethosomes combined with silk fibroin nanofibers is useful in transcutaneous immunization

Yang, Xingxing; Wang, Xiaoyun; Hong, Huoyan; El-Fawal, Gomaa F.; Lin, Shengrong; Wu, Jinglei; Jiang, Yuxin; He, Chuanglong; Mo, Xiumei; Kai, Guoyin; Wang, Hongsheng

doi:10.1016/j.jconrel.2020.07.047

Cited by 31 publications

(20 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eth-HA-GC/SF loaded with OVA can increase the expression of marker molecules (CD80, CD86) associated with DCs maturation in BMDCs and improve the expression of IFN-γ and IL-6 in spleen cells. Eth-HA-GC/SF is considered to have the good immunotherapeutic potential [ 187 ]. Chemically modified polysaccharides often exhibit immunomodulatory capabilities.…”

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

See 1 more Smart Citation

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

Materials derived from natural plants and animals have great potential for transdermal drug delivery. Polysaccharides are widely derived from marine, herbal, and microbial sources. Compared with synthetic polymers, polysaccharides have the advantages of non-toxicity and biodegradability, ease of modification, biocompatibility, targeting, and antibacterial properties. Currently, polysaccharide-based transdermal drug delivery vehicles, such as hydrogel, film, microneedle (MN), and tissue scaffolds are being developed. The addition of polysaccharides allows these vehicles to exhibit better-swelling properties, mechanical strength, tensile strength, etc. Due to the stratum corneum’s resistance, the transdermal drug delivery system cannot deliver drugs as efficiently as desired. The charge and hydration of polysaccharides allow them to react with the skin and promote drug penetration. In addition, polysaccharide-based nanotechnology enhances drug utilization efficiency. Various diseases are currently treated by polysaccharide-based transdermal drug delivery devices and exhibit promising futures. The most current knowledge on these excellent materials will be thoroughly discussed by reviewing polysaccharide-based transdermal drug delivery strategies.

show abstract

Section: Polysaccharide Based Drug Delivery For Diseases Therapeuticsmentioning

confidence: 99%

“… A schematic diagram of the preparation of the Eth-HA-GC/SF loaded OVA, causing cellular and humoral immune responses in the mouse model [ 187 ]. Reproduced with permission from Xingxing Yang, Journal of Controlled Release; published by Elsevier, 2020.…”

Section: Figurementioning

confidence: 99%

Polysaccharide-Based Transdermal Drug Delivery

Xiang

Zhang

et al. 2022

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Evaluation of safety and efficacy using other antigens, application suggested by authors in oncology [87] High ethanolic content can be a "double-edged sword", producing high drug entrapment, but also large leakage.…”

Section: Liposomesmentioning

confidence: 99%

The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

et al. 2021

View full text Add to dashboard Cite

The World Health Organization estimates that the pandemic caused by the SARS-CoV-2 virus claimed more than 3 million lives in 2020 alone. This situation has highlighted the importance of vaccination programs and the urgency of working on new technologies that allow an efficient, safe, and effective immunization. From this perspective, nanomedicine has provided novel tools for the design of the new generation of vaccines. Among the challenges of the new vaccine generations is the search for alternative routes of antigen delivery due to costs, risks, need for trained personnel, and low acceptance in the population associated with the parenteral route. Along these lines, transdermal immunization has been raised as a promising alternative for antigen delivery and vaccination based on a large absorption surface and an abundance of immune system cells. These features contribute to a high barrier capacity and high immunological efficiency for transdermal immunization. However, the stratum corneum barrier constitutes a significant challenge for generating new pharmaceutical forms for transdermal antigen delivery. This review addresses the biological bases for transdermal immunomodulation and the technological advances in the field of nanomedicine, from the passage of antigens facilitated by devices to cross the stratum corneum, to the design of nanosystems, with an emphasis on the importance of design and composition towards the new generation of needle-free nanometric transdermal systems.

show abstract

“…It also inhibited tumor growth in E.G7 tumor challenge by stimulating anti‐OVA immune response, suggesting the potential application of nanofibrous mats for TCI. 92 …”

Section: Noninvasive Transcutaneous Immunizationmentioning

confidence: 99%

Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

Sallam

Prakash

Kumbhojkar

et al. 2021

Bioengineering & Transla Med

View full text Add to dashboard Cite

A growing variety of biological macromolecules are in development for use as active ingredients in topical therapies and vaccines. Dermal delivery of biomacromolecules offers several advantages compared to other delivery methods, including improved targetability, reduced systemic toxicity and decreased degradation of drugs. However, this route of delivery is hampered by the barrier function of the skin. Recently, a large body of research has been directed towards improving the delivery of macromolecules to the skin, ranging from nucleic acids to antigens, using noninvasive means. In this review, we discuss the latest formulation-based efforts to deliver antigens and nucleic acids for vaccination and treatment of skin diseases. We provide a perspective of their advantages, limitations and potential for clinical translation. The delivery platforms discussed in this review may provide formulation scientists and clinicians with a better vision of the alternatives for dermal delivery of biomacromolecules, which may facilitate the development of new patientfriendly prophylactic and therapeutic medicines.

show abstract

Galactosylated chitosan-modified ethosomes combined with silk fibroin nanofibers is useful in transcutaneous immunization

Cited by 31 publications

References 45 publications

Polysaccharide-Based Transdermal Drug Delivery

Polysaccharide-Based Transdermal Drug Delivery

The Importance of Nanocarrier Design and Composition for an Efficient Nanoparticle-Mediated Transdermal Vaccination

Formulation‐based approaches for dermal delivery of vaccines and therapeutic nucleic acids: Recent advances and future perspectives

Contact Info

Product

Resources

About