Galactose-PEG dual conjugation of β-(1→3)-d-glucan schizophyllan for antisense oligonucleotides delivery to enhance the cellular uptake☆

Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kimitaka; Hasegawa, Takeshi; Numata, Munenori; Shinkai, Seiji

doi:10.1016/j.biomaterials.2005.08.023

Cited by 27 publications

(16 citation statements)

References 31 publications

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“…3)-D-glucan SPG for delivery of antisense oligonucleotides. This dual conjugation facilitates enhancement in cellular uptake along with endocytosis escape (Karinaga et al 2006). Blood clearance of SPG was found to be confirmation dependent.…”

Section: Schizophyllanmentioning

confidence: 99%

Cationic Polymers for the Delivery of Therapeutic Nucleotides

et al. 2015

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Section: Schizophyllanmentioning

confidence: 99%

Cationic Polymers for the Delivery of Therapeutic Nucleotides

et al. 2015

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“…Reductive amination is then carried out by first treating the oxidized schizophyllan with a bisamino(polyethyleneglycol) that has been derivatized with lactose, and then with sodium cyanoborohydride. This sequence of reactions introduces lactose into schizophyllan (as in 7), which on one hand can associate with DNA, and on the other hand can be recognized by asiaoglycoprotein receptors [82][83][84][85][86][87][88][89].…”

Section: Complexation Through Nucleic Acid-polysaccharide Interactionmentioning

confidence: 99%

Glycotargeting to improve cellular delivery efficiency of nucleic acids

Yan

Tram

2007

Glycoconj J

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Nucleic acids bearing glycans of various structures have been under vigorous investigation in the past decade. The carbohydrate moieties of such complexes can serve as recognition sites for carbohydrate-binding proteins-lectins-and initiate receptor-mediated endocytosis. Therefore, carbohydrates can enhance cell targeting and internalization of nucleic acids that are associated with them and thus improve the bioavailability of nucleic acids as therapeutic agents. This review summarizes nucleic acid glycosylation in nature and approaches for the preparation of both non-covalently associated and covalently-linked carbohydrate-nucleic acid complexes.

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“…Schizophyllan has been modified with galactose and PEG units to enhance cellular uptake. It has been observed that the antisense effect was maximized with the use of schizophyllan derivative when the complex is administered to hepatoblastoma HepG2 and melanoma A375 cell lines [55]. Thus, 1,3--glucan based drug delivery devices serve as biocompatible carriers for a variety of nucleotides.…”

Section: Glucan Complexes With Polynucleotidesmentioning

confidence: 99%