Galactomannan More than Pectin Exacerbates Liver Injury in Mice Fed with High‐Fat, High‐Cholesterol Diet

Shtriker, Miriam G.; Peri, Irena; Taieb, Elise; Nyska, Abraham; Tirosh, Oren; Madar, Zecharia

doi:10.1002/mnfr.201800331

Cited by 11 publications

(6 citation statements)

References 38 publications

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“…The abundance of Turicibacterales, which produce butyrate, has been shown to inversely correlate with the NAFLD phenotype, and has been found to be reduced in NAFLD patients [26]. Interestingly, there was no increase in the abundance of proteobacteria at this dose of pectin, in contrast to previous studies using higher doses [15,27].…”

Section: Discussioncontrasting

confidence: 57%

“…Indeed, the impact of dietary fiber on gut microbiota has been clearly established [13]. It has been shown that fiber prevents liver injury, depending on the type; galactomannan worsens liver injury, whereas inulin or pectin may improve it [14][15][16]. Moreover, we have already demonstrated that pectin alters IM composition and improves alcohol-induced liver injury [17] by increasing the abundance of Bacteroides, bacteria for which the abundance is decreased in NAFLD.…”

Section: Introductionmentioning

confidence: 94%

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Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

et al. 2021

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Pectin, a soluble fiber, improves non-alcoholic fatty-liver disease (NAFLD), but its mechanisms are unclear. We aimed to investigate the role of pectin-induced changes in intestinal microbiota (IM) in NAFLD. We recovered the IM from mice fed a high-fat diet, treated or not with pectin, to perform a fecal microbiota transfer (FMT). Mice fed a high-fat diet, which induces NAFLD, were treated with pectin or received a fecal microbiota transfer (FMT) from mice treated with pectin before (preventive FMT) or after (curative FMT) being fed a high-fat diet. Pectin prevented the development of NAFLD, induced browning of adipose tissue, and modified the IM without increasing the abundance of proteobacteria. Preventive FMT also induced browning of white adipose tissue but did not improve liver steatosis, in contrast to curative FMT, which induced an improvement in steatosis. This was associated with an increase in the concentration of short-chain fatty acids (SCFAs), in contrast to preventive FMT, which induced an increase in the concentration of branched SCFAs. Overall, we show that the effect of pectin may be partially mediated by gut bacteria

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 94%

Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

et al. 2021

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“…Changes in Bacteroidetes/Firmicutes ratio were noticed, with all HFCD-fed groups presenting a higher ratio compared with the ND group. Our results are similar to previous studies showing elevated Bacteroidetes/Firmicutes ratio in NASH patients and animal models (40)(41)(42)(43).…”

Section: Discussionsupporting

confidence: 93%

Broccoli consumption attenuates inflammation and modulates gut microbiome composition and gut integrity-related factors in mice fed with a high-fat high-cholesterol diet

Zandani

Anavi-Cohen

Sela

et al. 2021

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Background: Nonalcoholic fatty-liver disease (NAFLD) is a global health problem associated with gut dysbiosis and intestinal permeability. Broccoli is a natural source of bioactive phytochemicals, characterized by health-promoting properties. Objective: This study evaluated the effect of broccoli florets and stalks on liver fat accumulation, inflammation, gut microbiome, and intestinal barrier integrity. Design: Male C57BL/6J mice (n = 32, 8-week-old) were fed with a high-fat high-cholesterol diet (HFCD) with/without 15% broccoli (florets or stalks) for 7 weeks. Liver damage was evaluated by changes in glucose response and histological and biochemical parameters. Protein and gene expressions related to liver inflammation were examined. The effect of broccoli on microbiota population together with genes related to barrier integrity in the gut was investigated. Results: Dietary broccoli improved the glycemic response assessed by oral glucose tolerance test (OGTT). Histological evaluation showed no change in hepatic steatosis. Broccoli consumption also attenuated inflammation as revealed by lower inducible nitric oxide synthase (iNOS) and serum amyloid A1 (SAA1) expression levels in broccoli-supplemented groups. Gut microbiota analysis demonstrated elevated Acidifaciens and reduced Mucispirillum schaedleri abundance in the stalks group, whereas Proteobacteria strains abundance was increased in the florets group. Gut integrity remained unchanged. Conclusion: Broccoli supplementation improves glucose tolerance, attenuates liver inflammation, and alters microbial composition, but does not affect gut integrity. This research provides new evidence on the effects of dietary broccoli under HFCD.

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“…When a lipid metabolism disorder occurs, the liver is unable to transport fat in a timely manner, thus causing fat to accumulate in liver cells and resulting in fatty liver. Fat accumulation in the liver affects liver function and destroys liver cells, subsequently reducing the liver compensatory capacity and causing connective tissue hyperplasia, cirrhosis, and liver damage [16]. (2) Pre-existing dyslipidemia indirectly contributes to liver damage after chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

et al. 2019

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Background This study aims to investigate the effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy. Method A total of 428 patients with malignant tumors with normal liver function in our hospital between May 2013 to June 2018 were divided into an observation group (lipid metabolism disorder, n = 265) and control group (normal lipid metabolism, n = 163). The lipid metabolism levels and liver damage of the two groups were compared before and after chemotherapy. Results No significant differences in age, gender, body mass index, tumor types, history of surgery, levels of alanine aminotransferase (ALT; an indicator of liver function), and chemotherapy regimen were observed between the two groups. However, the observation group showed increased levels of total cholesterol ( P = 0.000), triglycerides ( P = 0.000), and low-density lipoprotein ( P = 0.01), as well as decreased levels of high-density lipoprotein ( P = 0.000) before chemotherapy compared with the control group. Furthermore, patients with lipid metabolism disorders were more likely to develop abnormal liver function after chemotherapy. Moreover, mixed lipid metabolism disorder was more likely to cause severe liver damage after chemotherapy. Additionally, the number of patients with lipid metabolism disorders after chemotherapy ( n = 367) was significantly increased compared with before chemotherapy ( n = 265) ( P < 0.01), indicating that chemotherapy might induce or aggravate an abnormal lipid metabolism. Conclusions After receiving chemotherapy, patients with malignant tumors presenting lipid metabolism disorders are more prone to liver damage and lipid metabolism disorders than patients with a normal lipid metabolism.

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Galactomannan More than Pectin Exacerbates Liver Injury in Mice Fed with High‐Fat, High‐Cholesterol Diet

Abstract: In a NASH mouse model, galactomannan increases liver damage but improves glucose metabolism. Changes in the microbiota composition may answer this enigmatic observation.

Cited by 11 publications

References 38 publications

Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

Gut Microbiota Reshaped by Pectin Treatment Improves Liver Steatosis in Obese Mice

Broccoli consumption attenuates inflammation and modulates gut microbiome composition and gut integrity-related factors in mice fed with a high-fat high-cholesterol diet

Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

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