Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

Sun, Yan V.; Zhang, Nie; Ding, Yuanhua; Yu, Lijiang; Cai, Jianfei; Ma, De; Wu, Yang; Lu, Wang-Kun; Niu, Jingyang

doi:10.1186/s12944-019-1063-y

Cited by 12 publications

(5 citation statements)

References 21 publications

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“…We used IHC analysis to indicate that patients with advanced age and higher serum levels of LDL and TG had higher expression of LYRM4 protein (Table 2 ). We speculated that high expression of LYRM4 may lead to cellular metabolic reprogramming and lipid metabolism disorders by modulating Fe-S cluster assembly, regulating the tricarboxylic acid cycle and β-oxidation [ 47 , 48 ], which would increase the burden on the liver and thus adversely affect the prognosis of LIHC patients [ 49 , 50 ]. Unfortunately, we did not find any other significant differences between the clinicopathological and LYRM4 expression.…”

Section: Discussionmentioning

confidence: 99%

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

et al. 2021

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Background LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of NFS1. However, the role of LYRM4 in liver hepatocellular carcinoma (LIHC) remains unclear. Methods In this study, we combined bioinformatics analysis and clinical specimens to evaluate the mRNA, protein expression, and gene regulatory network of LYRM4 in LIHC. Furthermore, we detected the activity of several classical iron-sulphur proteins in LIHC cell lines through UV-vis spectrophotometry. Results The mRNA and protein levels of LYRM4 were upregulated in LIHC. Subsequent analysis revealed that the LYRM4 mRNA expression was related to various clinical stratifications, prognosis, and survival of LIHC patients. In addition, the mRNA expression of LYRM4 was significantly associated with ALT, tumour thrombus, and encapsulation of HBV-related LIHC patients. IHC results confirmed that LYRM4 was highly expressed in LIHC tissues and showed that the expression of LYRM4 protein in LIHC was significantly correlated with age and serum low-density lipoprotein (LDL) and triglyceride (TG) content. In particular, the mRNA expression of key iron- sulphur proteins POLD1 and PRIM2 was significantly overexpressed and correlated with poor prognosis in LIHC patients. Compared with hepatocytes, the activities of mitochondrial complex I and aconitate hydratase (ACO2) in LIHC cell lines were significantly increased. These results indicated that the iron-sulphur cluster (ISC) biosynthesis was significantly elevated in LIHC, leading to ISC-dependent metabolic reprogramming. Changes in the activity of ISC-dependent proteins may also occur in paracancerous tissues. Further analysis of the biological interaction and gene regulation networks of LYRM4 suggested that these genes were mainly involved in the citric acid cycle and oxidative phosphorylation. Finally, LYRM4 expression in LIHC was significantly positively correlated with the infiltrating levels of six immune cell types, and both factors were strongly associated with prognosis. Conclusion LYRM4 could be a novel prognostic biomarker and molecular target for LIHC therapy. In particular, the potential regulatory networks of LYRM4 overexpression in LIHC provide a scientific basis for future research on the role of the ISC assembly mechanism and LYRM4-mediated sulphur transfer routes in carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

et al. 2021

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“…Computer tomography is utilized in the clinical identification process to provide assistance to radiologists in the detection of aberrant changes. CT imaging can give information that assists in medical diagnosis by allowing different types of tissues to be identified depending on the grey levels of the picture [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Image Processing and Machine Learning-Based Classification and Detection of Liver Tumor

Prasad

Prasad²,

Sawale³

et al. 2022

BioMed Research International

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The liver is in charge of a plethora of tasks that are critical to healthy health. One of these roles is the conversion of food into protein and bile, which are both needed for digestion. Inhaled and possibly harmful chemicals are flushed from the body. It destroys numerous nutrients acquired through the gastrointestinal system and limits the release of cholesterol by utilizing vitamins, carbohydrates, and minerals stored in the liver. The body’s tissues are made up of tiny structures known as cells. Cells proliferate and divide in order to create new ones in the normal sequence of events. When an old or damaged cell has to be replaced, a new cell must be synthesized. In other circumstances, the procedure is a total and utter failure. If the tissues of dead or damaged cells that have been cleared from the body are not removed, they may give birth to nodules and tumors. The liver can produce two types of tumors: benign and malignant. Malignant tumors are more dangerous to one’s health than benign tumors. This article presents a technique for the classification and identification of liver cancers that is based on image processing and machine learning. The approach may be found here. During the preprocessing stage of picture creation, the fuzzy histogram equalization method is applied in order to bring about a reduction in image noise. After that, the photographs are divided into many parts in order to zero down on the area of interest. For this particular classification task, the RBF-SVM approach, the ANN method, and the random forest method are all applied.

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“…Chemotherapy-induced liver damage in cancer patients may occur during chemotherapy or after the total course. Although liver function impairment may be reversed in some patients after the treatment, abnormal liver function may lead to an interruption of anti-tumor therapy and jeopardize the prognosis of patients [14]. Curcumin has also been used to support liver function and to treat jaundice in both Ayurvedic and Chinese herbal medicine [15].…”

Section: Resultsmentioning

confidence: 99%

Curcumin as an Alternative Medicine for Terminal Stage Endometrial Cancer Patient (Case Report)

Manuaba¹

2020

Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Curcumin has historically been used in anti-cancer therapies. However, the anti-metastatic effect and molecular mechanism of curcumin in endometrial carcinoma (EC) are still poorly understood. In this case, the patient administrated with 1,000 mg curcumin as an alternative medicine after completed operation and chemotherapy. To evaluate the effect of Curcumin as an alternative medicine after completed operation and chemotherapy of endometrial carcinoma. A 62 years old woman has been diagnosis with stage IV B endometrial cancer and was treated with Radical Hysterectomy and Omectectomy on April 18 th 2016. Patology result was endometrial carcinoma type endometrioid. After the operation, Paxus Carboplatin chemotherapy had been given for six series and finished on August 2016. In our experience, the life expectancy after completed surgical procedure and chemotherapy is not more than one year. This condition could make patient fell hopeless and ask for alternative treatment. In this case, the woman was administrated with 1,000 mg curcumin everyday which was started before the operation and continued after completed chemoterapy. During our observation, we found no side effect of using curcumin as an alternative medicine. She has free of any complaints in the year 2017. The relapse of endometrial cancer was found in July 2018. During 2018, we performed secondary debulking and continued with six series of Paxus Carboplatin chemotherapy. During 2018 until she died on January 28th 2019, her condition got worse. In this case, we have an experience using curcumin as an alternative medicine for terminal stage endometrial cancer patient which may increase the life expectancy for more than one year. Eventhougth we could not cure the patient, but we have an opportunity to prolong her life expectancy for more than 2 years with one year free of any complains. We have to conduct more research in curcumin as an alternative medicine for endometrial cancer patient to get more data of the efficacy of curcumin.

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Effect of lipid metabolism disorder on liver function in patients with malignant tumors after chemotherapy: a case-control study

Cited by 12 publications

References 21 publications

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma

Image Processing and Machine Learning-Based Classification and Detection of Liver Tumor

Curcumin as an Alternative Medicine for Terminal Stage Endometrial Cancer Patient (Case Report)

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