2002
DOI: 10.1177/08934402018003011
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Galactogogues: Medications That Induce Lactation

Abstract: Galactogogues are medications that aid in initiating and maintaining adequate milk production. Most exert their pharmacologic effects through interactions with dopamine receptors, resulting in increased prolactin levels and thereby augmenting milk supply. Metoclopramide remains the galactogogue of choice due to its documented record of efficacy and safety in women and infants. Domperidone crosses the blood brain barrier and into the breast milk to a lesser extent than metoclopramide, decreasing the risk of tox… Show more

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Cited by 87 publications
(101 citation statements)
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“…Extrapyramidal side effects, such as tardive dyskinesia (ϳ1%), can occur and are more common in women and children. 4,5 Although the medical literature reports a low incidence of depression, the widely held belief among women seeking to induce lactation is that depression is a very significant and common side effect. Therefore, many women choose to seek other alternatives.…”
Section: Metoclopramidementioning
confidence: 99%
See 1 more Smart Citation
“…Extrapyramidal side effects, such as tardive dyskinesia (ϳ1%), can occur and are more common in women and children. 4,5 Although the medical literature reports a low incidence of depression, the widely held belief among women seeking to induce lactation is that depression is a very significant and common side effect. Therefore, many women choose to seek other alternatives.…”
Section: Metoclopramidementioning
confidence: 99%
“…Long-term use is associated with hyperthyroidism. 4 Although written about in the literature, none of the currently popular protocols mention use of sulpiride, chlorpromazine, or TRH.…”
Section: 5mentioning
confidence: 99%
“…They act through exerting an influence on an adrenohypothalamohypophyseal-gonadal axis by inhibiting hypothalamic dopaminergic receptors or by inhibiting dopamine producing neurons. These medications increase prolactin secretion by antagonizing dopamine receptors (Gabay, 2002). Galactogogues stimulate the activity of alveolar tissue and raise the secretory activity and thereby restore and regulate milk yield (Ravikumar and Bhagwat, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…The use of 10 mg of metoclopramide, three times a day, for 7 to 14 days, has been effective and safe for continuance of breastfeeding in mothers of PTNB infants. 64,65 Although metoclopramide reaches high concentrations in breastmilk in relation to its serum level, 66,67 this drug is compatible with breastfeeding, provided that it is not used for long time periods. 68 Side effects include extrapyramidal reactions, dizziness, nausea and depression.…”
Section: Milk Expressionmentioning
confidence: 99%
“…Several substances have been described as galactogogues, but metoclopramide has been the most widely investigated. 64 This drug antagonizes dopamine secretion into the central nervous system and promotes lactation. The use of 10 mg of metoclopramide, three times a day, for 7 to 14 days, has been effective and safe for continuance of breastfeeding in mothers of PTNB infants.…”
Section: Milk Expressionmentioning
confidence: 99%