Gait patterns after intraarticular treatment of patients with osteoarthritis of the Knee - Hyaluronan versus triamcinolone: a prospective, randomized, doubleblind, monocentric study

Abstract

Objective Evaluation of gait performance and muscle activity patterns as well as clinical efficacy and safety after single intraarticular injection with hyaluronan compared with triamcinolone in patients with knee osteoarthritis. Materials and Methods This trial evaluated the influence of a single injection of hyaluronan or triamcinolone on gait pattern and muscle activity. For clinical evaluation a visual analogue scale for pain, Lequesne index, and Knee Society Score were used. Quality of life was assessed with the SF-36. Results The complete analysis was performed in 50 of 60 patients. 26 patients were treated with triamcinolone and 24 with hyaluronan. Hyaluronan treatment led to significant improvement of range of motion at hip and knee. Significant improvement could be either demonstrated for the pain scale, Lequesne and Knee Society score in both groups. Quality of life showed greater improvement in the triamcinolone group. Conclusion Single application of high-viscosity hyaluronan shows superior range of motion and pain reduction as well as improvement in clinical results. Even if there was a lack of significant differences compared to triamcinolone, this therapy classified as safe and effective in the short follow up.

Treatment of Hip Trochanteric Bursitis Using Hyaluronate Injections

“…The rationale for hyaluronate injection rests with its known anti-inflammatory effects as well as the possibility that its presence will restore normal tissue function. Indeed, previous studies have indicated that hyaluronate injections in the knee serve to ameliorate knee function and increase muscle strength by an unknown mechanism that does not occur with steroid injections [10,11]. It should be remembered that steroid injection particularly in diabetics is likely to raise glucose levels [12].…”

NASHA hyaluronic acid vs methylprednisolone for knee osteoarthritis: a prospective, multi-centre, randomized, non-inferiority trial

“…Previous studies in knee OA have demonstrated that NASHA provides significant post-treatment benefits, lasting for at least 6 months 12,13 . NASHA has also been shown to provide similar benefit to the corticosteroid triamcinolone acetonide (TA) in a 12-week study 14 .…”

Lower limb kinematics improvement after genicular nerve blockade in patients with knee osteoarthritis: a milestone study using inertial sensors

“…The pain decreased significantly after the intervention (NRS Pain median [25-75 interquartile range] respectively before and after injection: 8 [6][7][8][9][10], 0 [0-4]) (Fig. 2).…”