Gait characteristics of patients with knee osteoarthritis

Kaufman, Kenton R.; Hughes, Christine; Morrey, B.F.; Morrey, Michael A.; An, Kai Nan

doi:10.1016/s0021-9290(01)00036-7

Cited by 513 publications

(398 citation statements)

References 22 publications

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“…Gait alterations are often seen in people with knee OA during walking, which have been suggested to be an attempt to reduce pain and joint load (21,41). People with knee OA typically walk more slowly and with a reduced knee ROM during early stance, as well as a reduced total knee ROM, compared to asymptomatic control subjects (20,21).…”

Section: Discussionmentioning

confidence: 99%

“…People with knee OA typically walk more slowly and with a reduced knee ROM during early stance, as well as a reduced total knee ROM, compared to asymptomatic control subjects (20,21). Changes in knee joint moments in the sagittal plane have also been reported in people with knee OA compared to asymptomatic controls (42).…”

Section: Discussionmentioning

confidence: 99%

“…However, further research is needed to ascertain the causal relationship between the level of proinflammatory markers in the muscle and joints and gait in people with knee OA. Gait velocity is an important indicator for physical function and disability in older people (43), and a reduction in gait velocity is common in people with knee OA (20,21). It is essential to understand the factors underlying reduced gait velocity in OA.…”

Section: Discussionmentioning

confidence: 99%

“…Altered gait pattern is often observed in people with knee OA (20,21). Pain associated with knee OA has been thought to result in gait modification as an attempt to reduce the load on the affected joint, with studies reporting changes in joint loading as a response to pain relief (22)(23)(24), or pain induction in experimental trials (25,26).…”

Section: Introductionmentioning

confidence: 99%

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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Levinger

Caldow

Feller

et al. 2011

Arthritis Care & Research

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Objective. Patients with knee osteoarthritis (OA) are characterized by increased muscle inflammation and altered gait. We investigated the association between proinflammatory mediators in the vastus lateralis and physical function and gait in patients with knee OA. Methods. Nineteen patients with knee OA underwent gait analysis, assessment of self-reported pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), and a muscle biopsy that was taken during their knee replacement surgery. Muscle was analyzed for cellular protein inflammatory mediators, interleukin-6, monocyte chemotactic protein 1 (MCP-1), p65 NF-B, signal transducer and activator of transcription 3 (STAT-3), and JNK-1. Sagittal plane knee function, including early stance knee range of motion (ROM) and knee sagittal plane impulse, was measured using a motion analysis system. Pearson's correlation was used to assess relationships between selected variables. Results. Significant positive correlations were found between MCP-1 and self-perceived stiffness, physical function, and the total WOMAC score (P < 0.05). MCP-1 was also negatively correlated with early stance knee ROM (r ‫؍‬ ؊0.52, P ‫؍‬ 0.023). Reduced velocity was associated with elevated levels of p65 NF-B and STAT-3 (P < 0.05). Knee sagittal plane impulse was negatively correlated with JNK-1 (P ‫؍‬ 0.02), indicating reduction in knee impulse with an increased level of JNK-1. Conclusion. Increased levels of several proinflammatory mediators were correlated with altered knee function during walking as well as greater physical disability and slower gait velocity. Identification of the cellular and molecular mechanisms associated with muscle inflammation is important to better understand the underlying mechanism responsible for altered gait and function in patients with knee OA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Levinger

Caldow

Feller

et al. 2011

Arthritis Care & Research

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“…There is increasing interest in the contribution of biomechanical variables to the pathogenesis and management of osteoarthritis in addition to biologic factors. These include mainly the lower limb alignment and knee adduction moment forces increasing the load across the articular cartilage and/or changing the material properties [14][15][16][17][18][19]. There are several reports pointing out the aetio-pathogenetic relation between the osteoarthritis of the hip, knee and lower extremity torsion [3][4][5][6][7][8]10].…”

Section: Discussionmentioning

confidence: 99%

Is there a relation between hip torsion, coverage and osteoarthritis of the knee?

Hapa

Muratli

Çakıcı

et al. 2009

Journal of Children's Orthopaedics

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Purpose Biomechanic factors play a role in the pathogenesis of knee osteoarthritis. The aim of the study was to find out whether there is a relation between femoral, acetabular anteversions, anterior, posterior acetabular coverages and primary osteoarthritis of the knee. Methods Thirty patients with primary osteoarthritis of the knee and 29 control subjects were enrolled into the study. Femoral anteversion, acetabular anteversion, McKibbin's instability index, anterior acetabular sector and posterior acetabular sector angles were measured using tomographic scanograms. Results There was no difference between groups for each parameter (P [ 0.05). Conclusion This study did not show any relationship between the axial plane changes in the hip joint and primary knee osteoarthritis.

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Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

Henriksen¹,

Graven‐Nielsen²,

Aaboe³

et al. 2010

Arthritis Care & Research

141

100

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Objective. Medial knee osteoarthritis (OA) is characterized by pain and associated with abnormal knee moments during walking. The relationship between knee OA pain and gait changes remains to be clarified, and a better understanding of this link could advance the treatment and prevention of disease progression. This study investigated changes in knee moments during walking following experimental knee pain in healthy volunteers, and whether these changes replicated the joint moments observed in medial knee OA patients. Methods. In a crossover study, 34 healthy subjects were tested on 3 different days; gait analyses were conducted before, during, and after pain induced by hypertonic saline injections (0.75 ml) into the infrapatellar fat pad. Isotonic saline and sham injections were used as control conditions. Peak moments in frontal and sagittal planes were analyzed. The results were compared with data from 161 medial knee OA patients. The patients were divided into less severe OA and severe OA categories, which was based on radiographic disease severity of the medial compartment. Results. Experimental knee pain led to reduced peak moments in the frontal and sagittal planes in the healthy subjects, which were similar to the patterns observed in less severe OA patients while walking at the same speed. Conclusion. In healthy subjects, pain was associated with reductions in knee joint moments during walking in a manner similar to less severe knee OA patients. The experimental model may be used to study mechanically-driven knee OA progression and preventive measures against abnormal joint loading in knee OA.

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Gait characteristics of patients with knee osteoarthritis

Cited by 513 publications

References 22 publications

Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Is there a relation between hip torsion, coverage and osteoarthritis of the knee?

Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain

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