Safety culture and unsafe behavior have been considered to be important factors in operational safety in various fields, including transportation systems. The study sought to analyze the relationship between occupational health and safety and employee work outcomes, the moderating role of public service motivation and employee work outcomes, and transformational leadership and employee work outcomes. A cross-sectional survey using convenience sampling technique was adopted with a sample of 300 public transport bus drivers from Takoradi Market Circle, Ghana. A five-point Likert scale integrated questionnaire was used. The study use SmartPLS software 3.2.8 to analyze the data. The study found Occupational Health and Safety to have direct positive and significant relationship with Employee Work Outcomes. Furthermore, the study found public service motivation also have positive and significant connection with Employee Work Outcomes. Also, the study found support for the relationship between Transformational Leadership and Employee Work Outcomes. Again, transformational leadership moderates the relationship occupational health and safety and employee work outcomes. In a similar fashion, public service motivation was found to moderate the relationship between occupational health and safety and employee work outcomes. It is recommended that workshops and training sessions on safety to enhance the alignment of safety practices for drivers as industrial employees responsible for transport operations. Also, employers should implement safety reward programs that enable drivers to follow good levels of health and safety.