Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

Bai, Shuang; Zhang, Yang; Li, Dengfeng; Shi, Xiaoxiao; Lin, Gan; Liu, Gang

doi:10.1016/j.nantod.2020.101038

Cited by 61 publications

(38 citation statements)

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is ascribed to hydrophobicity and a small molecule structure of Ppa in comparison with a big size of SSAs. [ 22 ] Furthermore, compared with the control, both SSAs and Ppa are internalized and located into endosomes/lysosomes at 24 h, as exemplified in the TEM images of Figure 3c and Figure S30 (Supporting Information). These results reveal that SSAs could be effectively uptaken by 4T1 cells after a sufficient duration.…”

Section: Resultsmentioning

confidence: 90%

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

et al. 2021

View full text Add to dashboard Cite

Supramolecular self-assemblies of dendritic peptides with well-organized nanostructures have great potential as multifunctional biomaterials, yet the complex self-assembly mechanism hampers their wide exploration. Herein, a self-stabilized supramolecular assembly (SSA) constructed from a PEGylated dendritic peptide conjugate (PEG-dendritic peptide-pyropheophorbide a, PDPP), for augmenting tumor retention and therapy, is reported. The supramolecular self-assembly process of PDPP is concentration-dependent with multiple morphologies. By tailoring the concentration of PDPP, the supramolecular self-assembly is driven by noncovalent interactions to form a variety of SSAs (unimolecular micelles, oligomeric aggregates, and multi-aggregates) with different sizes from nanometer to micrometer. SSAs at 100 nm with a spherical shape possess extremely high stability to prolong blood circulation about 4.8-fold higher than pyropheophorbide a (Ppa), and enhance tumor retention about eight-fold higher than Ppa on day 5 after injection, which leads to greatly boosting the in vivo photodynamic therapeutic efficiency. RNA-seq demonstrates that these effects of SSAs are related to the inhibition of MET-PI3K-Akt pathway. Overall, the supramolecular self-assembly mechanism for the synthetic PEGylated dendritic peptide conjugate sheds new light on the development of supramolecular assemblies for tumor therapy.

show abstract

Section: Resultsmentioning

confidence: 90%

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The interactions between nanoparticles and cancer cells are significant, the properties of nanomaterials such as size, shape, and composition are closely related to the ability of cell uptake [23]. The dimensions are a strong determinant of total cell uptake, particles with a size of∼100 nm are suitable for the tumor-specific enhanced permeability and retention effect and possess high nanomaterial retention rate, and tend to accumulate in tumor site [24]. Combined with the particle size of C 3 N 4 @RP in figure 2(A), This result indicates that C 3 N 4 @RP nanosheets has been successfully constructed, and make them good candidates for cancer cell uptake.…”

Section: Resultsmentioning

confidence: 99%

Research on selective uptake of photosensitizer C₃N₄@RP by different cancer cells

Liu¹,

Chen²,

Lin³

et al. 2022

Mater. Res. Express

View full text Add to dashboard Cite

Photodynamic therapy (PDT), as a clinical treatment, can remove malignant cells upon laser irradiation by selective uptake of photosensitizer (PS). The relative contribution of these antitumor effects depends largely on the dose and uptake of PS. In this study, C3N4@RP was chosen as a candidate for selective uptake studies of different cancer cells. C3N4@RP has been proved to possess excellent properties, including absorption edges extending up to 700 nm, efficient cellular uptake, low cytotoxicity, and favorable intracellular fluorescence localization. Considering the optimal therapeutic effect, we first incubated different concentrations of PS with A549 cells and HeLa cells in vitro to observe the uptake efficiency at different times. At a concentration of 20 µg mL−1, the cellular uptake by A549 and HeLa showed a time-dependent accumulation. The increasing accumulation for cancer cells at the most effective cellular uptake for 24 h follows an order of HeLa > A549. These results suggest that different types of cancer cells have different uptake saturation times for the same PS. All of the presented results support the idea that a properly designed PS is suitable for specific cancer at a specific time to achieve the best therapeutic effect.

show abstract

“…Cancer is a heterogeneous disease which differs from normal tissue in morphology and growth mode [ 55 , 56 , 57 ]. The rapid proliferation of tumor cells leads to the characteristic changes in energy metabolism [ 58 , 59 ]. Tumor cells are vigorous with respect to energy metabolism, consuming large amounts of glucose and converting it to lactate, resulting in an increase in extracellular H + concentration and a decrease in pH value [ 18 , 60 , 61 ].…”

Section: Activatable Nir-ii Fluorescent Probesmentioning

confidence: 99%

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Pan

et al. 2021

Biosensors

Self Cite

View full text Add to dashboard Cite

Recently, second near-infrared (NIR-II) fluorescent imaging has been widely applied in biomedical diagnosis, due to its high spatiotemporal resolution and deep tissue penetration. In contrast to the “always on” NIR-II fluorescent probes, the activatable NIR-II fluorescent probes have specific targeting to biological tissues, showing a higher imaging signal-to-background ratio and a lower detection limit. Therefore, it is of great significance to utilize disease-associated endogenous stimuli (such as pH values, enzyme existence, hypoxia condition and so on) to activate the NIR-II probes and achieve switchable fluorescent signals for specific deep bioimaging. This review introduces recent strategies and mechanisms for activatable NIR-II fluorescent probes and their applications in biosensing and bioimaging. Moreover, the potential challenges and perspectives of activatable NIR-II fluorescent probes are also discussed.

show abstract

Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

Cited by 61 publications

References 169 publications

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Research on selective uptake of photosensitizer C₃N₄@RP by different cancer cells

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Contact Info

Product

Resources

About

Gain an advantage from both sides: Smart size-shrinkable drug delivery nanosystems for high accumulation and deep penetration

Cited by 61 publications

References 169 publications

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Research on selective uptake of photosensitizer C3N4@RP by different cancer cells

Activatable Second Near-Infrared Fluorescent Probes: A New Accurate Diagnosis Strategy for Diseases

Contact Info

Product

Resources

About

Research on selective uptake of photosensitizer C₃N₄@RP by different cancer cells