Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications

Rhee, Hyungjin; Cho, Eun-Suk; Nahm, Ji Hae; Jang, Mi; Chung, Yong Eun; Baek, Seung-Min; Lee, Sunyoung; Kim, Do Young; Park, Mi-Suk; Han, Dai Hoon; Choi, Jin Young; Park, Young Nyun

doi:10.1016/j.jhep.2020.08.013

Cited by 78 publications

(57 citation statements)

References 30 publications

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“…However, the relatively narrow CIs of the estimated ORs in our study should be attributed to the higher prevalence of the two subtypes. Recently, Rhee et al (17) found that arterial phase hypovascular component on gadoxetic acid-enhanced MRI could help stratify the probability of MTM HCC. Intratumor necrosis is not a generally reported feature of aggressiveness for HCC but is regarded as an LR-M feature of non-HCC malignancy (18).…”

Section: Discussionmentioning

confidence: 99%

Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma

Feng

Zhao

et al. 2021

Radiology

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Background: Macrotrabecular-massive (MTM) subtype and vessels encapsulating tumor clusters (VETC) pattern of hepatocellular carcinoma (HCC) are associated with unfavorable prognosis.Purpose: To estimate the potential of preoperative CT in the prediction of MTM subtype and VETC pattern. Materials and Methods:Patients who underwent surgical resection or liver transplant and preoperative CT for HCC between January 2015 and June 2018 were retrospectively included in the primary cohort. CT imaging features were evaluated by two radiologists. Predictors associated with the MTM subtype or VETC pattern were determined by using logistic regression analyses and the performance was tested in a validation cohort. Prognostic factors associated with early recurrence after surgical resection were identified by using Cox regression analyses. Results:The primary cohort included 170 patients (median age, 55 years; interquartile range, 48-63 years; 152 men). Serum -fetoprotein level higher than 100 ng/mL (odds ratio [

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Section: Discussionmentioning

confidence: 99%

Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma

Feng

Zhao

et al. 2021

Radiology

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“…Indeed, the extent of tumor necrosis may also be affected by the larger HCC size. In a recent multicenter study, Rhee et al [14] developed two diagnostic criteria based on hypovascular components during the hepatic arterial phase to identify MTM-HCC on gadoxetate disodium MRI. However, after scoring APHE hypovascular components were classified into 11 different patterns, which could be challenging in clinical practice with possible negative effects on inter-reader variability, especially with less experienced readers [15].…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

“…For instance, the MTM-HCC subtype has been reported to be an independent predictor of early and overall recurrence in patients after either surgical resection or radiofrequency ablation. 6 Only a few studies have described the imaging features of HCC subtypes, in particular MTM-HCC [10] , [11] , [12] , [13] , [14] , [15] , [16] and SH-HCC. 17 These studies have focused on a combination of subjectively defined qualitative imaging features on computed tomography (CT) and magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS

et al. 2021

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…A new subtype was recently described, which is the macrotrabecular variant of HCC, with an aggressive phenotype, frequent satellite nodules and both macro and micro‐vascular invasion 17 . Because of the clinical relevance of this aggressive phenotype, two studies evaluated whether preoperative imaging could help identify the macrotrabecular histological subtype 18,19 . These two studies, performed on pre‐operative MRI in 152 and 476 patients with HCC treated with surgical resection, showed that specific MRI features such as tumor heterogeneity and arterial phase hypoenhancement could be suggestive of this subtype.…”

Section: Examples Of Advances As a Results Of Quantitative Models For Hepatocellular Carcinomamentioning

confidence: 99%

“…17 Because of the clinical relevance of this aggressive phenotype, two studies evaluated whether preoperative imaging could help identify the macrotrabecular histological subtype. 18,19 These two studies, performed on pre-operative MRI in 152 and 476 patients with HCC treated with surgical resection, showed that specific MRI features such as tumor heterogeneity and arterial phase hypoenhancement could be suggestive of this subtype. To date, no radiomics-based study has been performed to characterize subtypes of HCC, but this could become an interesting field of research.…”

Section: Keeping Up With Recent Improvements In Pathological Correlations: Radio-pathology Integrationmentioning

confidence: 99%

HCC advances in diagnosis and prognosis: Digital and Imaging

Sartoris

Grégory

Burgio

et al. 2021

Liver International

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Hepatocellular carcinoma (HCC) is a major cause of cancer‐related death worldwide. Understanding of the pathogenesis of HCC has significantly improved in the past few years due to advances in genetics, molecular biology and pathology. Several subtypes have been identified with different backgrounds and outcomes, leading to possible changes in disease management and challenging the role of imaging. Indeed, despite its pivotal role in the diagnostic workup, prognosis, and the decision‐making process in patients with HCC, these recent developments are progressively redefining the role of imaging. First and most important, liver imaging is shifting from a purely qualitative to a quantitative paradigm, integrating quantitative imaging and radiomics in a digital era. Second, to improve patient management, imaging has gradually moved beyond tumor‐centered assessment to include a broader evaluation of the liver and its function. This review describes and discusses these advances in the imaging for the diagnosis and prognosis of HCC.

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Gadoxetic acid-enhanced MRI of macrotrabecular-massive hepatocellular carcinoma and its prognostic implications

Cited by 78 publications

References 30 publications

Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma

Preoperative CT for Characterization of Aggressive Macrotrabecular-Massive Subtype and Vessels That Encapsulate Tumor Clusters Pattern in Hepatocellular Carcinoma

Imaging features of histological subtypes of hepatocellular carcinoma: Implication for LI-RADS

HCC advances in diagnosis and prognosis: Digital and Imaging

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