Gadolinium- or iodine-based contrast media: which choice?

Thomsen, Henrik S.

doi:10.1177/0284185114533537

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…The last several decades have witnessed tremendous progress in nonionic ICMs. However, their clinical applications are still hampered by some limitations: (1) rapid renal excretion and thus a very short circulation time [ 10 , 14 , 15 ]; (2) serious adverse effects, especially contrast-induced nephropathy (CIN), with potential life-threatening injuries [ 16 , 17 ]; (3) inefficient targetability and thus unclear CT imaging at target lesions [ 18 , 19 ]. In order to address these limitations, great efforts have been made to develop and optimize these small-molecule ICMs [ 8 , 9 , 20 , 21 , 22 , 23 ].…”

Section: Iodinated Macromolecular Contrast Mediamentioning

confidence: 99%

Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging

Zhang

Guo

et al. 2021

Molecules

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X-ray computed tomography (CT) imaging can produce three-dimensional and high-resolution anatomical images without invasion, which is extremely useful for disease diagnosis in the clinic. However, its applications are still severely limited by the intrinsic drawbacks of contrast media (mainly iodinated water-soluble molecules), such as rapid clearance, serious toxicity, inefficient targetability and poor sensitivity. Due to their high biocompatibility, flexibility in preparation and modification and simplicity for drug loading, organic nanoparticles (NPs), including liposomes, nanoemulsions, micelles, polymersomes, dendrimers, polymer conjugates and polymeric particles, have demonstrated tremendous potential for use in the efficient delivery of iodinated contrast media (ICMs). Herein, we comprehensively summarized the strategies and applications of organic NPs, especially polymer-based NPs, for the delivery of ICMs in CT imaging. We mainly focused on the use of polymeric nanoplatforms to prolong circulation time, reduce toxicity and enhance the targetability of ICMs. The emergence of some new technologies, such as theragnostic NPs and multimodal imaging and their clinical translations, are also discussed.

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Section: Iodinated Macromolecular Contrast Mediamentioning

confidence: 99%

Organic Nanoplatforms for Iodinated Contrast Media in CT Imaging

Zhang

Guo

et al. 2021

Molecules

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“…The last several decades have witnessed tremendous progress in nonionic ICAs. However, their clinical applications are still hampered by some limitations: (1) serious adverse effects, such as allergic reactions and contrast-induced nephropathy (CIN) with potential life-threatening injuries, especially for the patients with chronic renal disease; , (2) rapid renal excretion, resulting in a very short circulation time and thus a very narrow imaging window; ,, (3) nonspecific distribution, leading to unclear CT imaging at some target lesions. , Great efforts have been made to develop and optimize these small molecule ICAs to address these limitations. ,,,− …”

Section: Iodine-based Contrast Agentsmentioning

confidence: 99%

Polymers for Improved Delivery of Iodinated Contrast Agents

Zhang

Liu

Zhang

et al. 2021

ACS Biomater. Sci. Eng.

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X-ray computed tomography (CT), as one of the most widely used noninvasive imaging modalities, can provide three-dimensional anatomic details with high resolution, which plays a key role in disease diagnosis and treatment assessment. However, although they are the most prevalent and FDA-approved contrast agents, iodinated water-soluble molecules still face some challenges in clinical applications, such as fast clearance, serious adverse effects, nonspecific distribution, and low sensitivity. Because of their high biocompatibility, tunable designability, controllable biodegradation, facile synthesis, and modification capability, the polymers have demonstrated great potential for efficient delivery of iodinated contrast agents (ICAs). Herein, we comprehensively summarized the applications of multifunctional polymeric materials for ICA delivery in terms of increasing circulation time, decreasing nephrotoxicity, and improving the specificity and sensitivity of ICAs for CT imaging. We mainly focused on various iodinated polymers from the aspects of preparation, functionalization, and application in medical diagnosis. Future perspectives for achieving better imaging and clinical translation are also discussed to motivate new technologies and solutions.

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“…Therefore, we should still identify patients with GFR below 30 mL/min 1.73 m 2 and carefully evaluate whether the requested study should be performed under hydration or the patients should be MR-imaged or studied with an unenhanced CT scanning. If MRI and CT are equal for diagnostic point of view, one will still prefer to do enhanced MRI with a cyclic gadolinium-based contrast agent instead of CT with an iodine-based contrast medium (19). Major prospective studies involving inpatients and outpatients who have a GFR between 45 and 30 mL/min 1.73 m 2 and who have GFR below 30 mL/min 1.73 m 2 are strongly warranted.…”

mentioning

confidence: 99%