Gadolinium Neutron Capture Therapy

Comparison of Radiation Effects of Gadolinium and Boron Neutron Capture Reactions

“…Advantage ratios for parallel opposing irradiation, a ratio between tumor doses with and without Gd-157, were 2.87 and 1.48, respectively for the tumor containing 100 µg/ml Gd. These data suggest that significantly enhanced effects can be achieved with Gd-157 [11].…”

“…In the process of Gd-neutron capture, photons and electrons of various energy levels are released [11]. The effect of photons with long flight ranges is significant for a large volume as gamma ray absorption increases proportionally with treatment volume.…”

“…Monte Carlo calculations have revealed that the tumor to normal tissue ratio and advantage ratio in the above conditions were 1.48 and 2.87 for Gd-neutron capture reactions, and 1.32, 2.36 for B-neutron capture reactions with a B-10 concentration of 30 µg/ml [11]. These physical calculations, however, have limitations in evaluating biological effectiveness because dose distributions in the cell cannot be fully defined.…”

“…In contrast to B-neutron capture, gadolinium (Gd) neutron capture results in release of gamma rays followed by a series of low-energy conversion and Auger electrons [2,7], a favorable characteristic because the location of the element is not critical with regard to the target cell due to their longer flight ranges. Monte Carlo calculations have suggested that over-all radiation effects are nearly equal for Gd-157 and B-10 at an equal molecular concentration [11].…”

Gadolinium concentration analysis in brain phantom by X-ray fluorescence

“…In recent years the stable element Gd has received a lot of attention in research with regards to NCT, which is a promising radiation therapy for brain cancer treatment [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25]. In this type of treatment, a non-radioactive compound that contains Gd, an element with a high thermal neutron absorption cross section for neutron reactions, is introduced into the patient.…”