Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver

Kabalka, George W.; Buonocore, Edward; Hübner, Karl; Davis, M.A.F.; Huang, Leaf

doi:10.1002/mrm.1910080111

Cited by 93 publications

(45 citation statements)

References 19 publications

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“…[13][14][15][16][17] The properties of the contrast agents that are important for the tissue specificity include molecular size, charge and lipophilicity. Since most of the specific cell-cell interactions or recognitions are regulated by special proteins, receptor targeting can be attained by mimicking signal peptides.…”

Section: Introductionmentioning

confidence: 99%

Bis(phenylethylamide) Derivatives of Gd‐DTPA as Potential Receptor‐Specific MRI Contrast Agents

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Bis(phenylethylamide) Derivatives of Gd‐DTPA as Potential Receptor‐Specific MRI Contrast Agents

et al. 2007

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“…A disadvantage of this approach is the leakage of low-molecular-weight compounds from the vesicles in vivo. Alternatively, liposomal contrast agents were prepared using membraneincorporated reporter metal-loaded chelating agents such as Gd-DTPA-stearylamine (DTPA-SA), Gd-DTPAphosphatidyl ethanolamine (DTPA-PE), and amphiphilic acylated paramagnetic complexes of Mn and Gd (3)(4)(5). All these agents act by increasing longitudinal relaxation rates R1 of surrounding water protons, resulting in an increase of tissue signal intensity.…”

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confidence: 99%

Enhanced tumor MR imaging with gadolinium‐loaded polychelating polymer‐containing tumor‐targeted liposomes

Erdoğan

Medarova

Roby

et al. 2008

Magnetic Resonance Imaging

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Purpose: To significantly enhance tumor MR imaging by using a contrast agent combining three components-a long-circulating liposome, liposomal membrane-incorporated polychelating amphiphilic polymer heavily loaded with gadolinium, and cancer-specific monoclonal antibody 2C5 attached to the liposome surface. Materials and Methods:Tumor-bearing animals were imaged prior and 4, 24, and 48 hours after i.v. injection of 2C5-modified and unmodified Gd-PAP-containing PEGylated liposomes. The faster and more specific accumulation of the novel contrast nanoparticles in tumors was also confirmed by 3D angiograms and by direct visualization of Gd-immunoliposomes in tumor sections by confocal microscopy.Results: 2C5-modified Gd-PAP-containing PEGylated liposomes allowed for fast and specific tumor imaging as early as 4 hours postinjection. T1 inversion recovery maps demonstrated a significant increase in tumor-associated R1 in animals injected with antibody-modified Gd-loaded liposomes 4 hours postinjection, followed by a gradual decrease consistent with clearance of the agent from the tumor region. In control animals injected with antibody-free liposomes the corresponding R1 values at all investigated timepoints were significantly smaller. Conclusion:The results support the feasibility of using such multifunctional nanoparticular liposome-based agents simultaneously providing prolonged circulation, heavy Gd load, and specific cancer cell recognition as a superior contrast for MR tumor imaging.

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“…Several chelating probes with an amphiphilic nature were previously developed for liposome membrane incorporation studies, such as DTPA-PE (Grant, Karlik, Florio, 1989), DTPA-stearylamine (DTPA-SA) (Kabalka et al, 1989), and amphiphilic acylated paramagnetic complexes of Mn and Gd (Unger et al, 1994). In these agents, a hydrophilic chelating residue is covalently linked to a hydrophobic (lipid) chain.…”

Section: Polymeric Micelles Labeled With Paramagnetic Metals For Mrimentioning

confidence: 99%

“…The use of micelles as possible carriers for tumor imaging agents involves the following factors: (i) the incorporation of gamma emitters such as 111 In or 99m Tc for gamma scintigraphy (Reddy, Sharma, Murthy, 2006;; (ii) the incorporation of paramagnetic gadolinium complexes for MRI application (Kabalka, 1989;Torchilin, 1994); and, (iii) X-ray computed tomography using iodine-containing polymeric micelles (Torchilin, Frank-Kamenetsky, Wolf, 1999;Trubetskoy et al, 1997).…”

Section: Polymeric Micelles For Diagnosis and Cancer Therapymentioning

confidence: 99%

Polymeric micelles and molecular modeling applied to the development of radiopharmaceuticals

Grallert

Rangel-Yagui

Pasqualoto

et al. 2012

Braz. J. Pharm. Sci.

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Micelles composed of amphiphilic copolymers linked to a radioactive element are used in nuclear medicine predominantly as a diagnostic application. A relevant advantage of polymeric micelles in aqueous solution is their resulting particle size, which can vary from 10 to 100 nm in diameter. In this review, polymeric micelles labeled with radioisotopes including technetium (99mTc) and indium (111In), and their clinical applications for several diagnostic techniques, such as single photon emission computed tomography (SPECT), gamma-scintigraphy, and nuclear magnetic resonance (NMR), were discussed. Also, micelle use primarily for the diagnosis of lymphatic ducts and sentinel lymph nodes received special attention. Notably, the employment of these diagnostic techniques can be considered a significant tool for functionally exploring body systems as well as investigating molecular pathways involved in the disease process. The use of molecular modeling methodologies and computer-aided drug design strategies can also yield valuable information for the rational design and development of novel radiopharmaceuticals.
Micelas poliméricas compostas de copolímeros ligadas a um elemento radioativo são utilizadas em Medicina Nuclear com aplicação predominantemente diagnóstica. A vantagem relevante da utilização de micelas poliméricas em solução aquosa é o tamanho de suas partículas, as quais podem variar de 10 a 100 nm de diâmetro. Neste trabalho de revisão são apresentadas micelas poliméricas marcadas com radioisotopos, como tecnécio-99m (99mTc) e índio-111 (111In), assim como suas aplicações clínicas em técnicas de diagnóstico como Tomografia por emissão de Fóton Único (Single photon Emission Computed Tomography - SPECT), cintilografia, e Ressonância Magnética Nuclear (RMN). Neste contexto, sua aplicação em diagnóstico de sistema linfático e linfonodo sentinela recebe atenção especial. O emprego de técnicas de diagnóstico pode ser considerado uma ferramenta importante para a exploração de sistemas no organismo humano assim como para a investigação de caminhos moleculares envolvidos nos processos de diversas doenças. O uso de metodologias de modelagem molecular e estratégias de desenvolvimento de fármacos assistidas computacionalmente também pode fornecer informações valiosas para o planejamento e o desenvolvimento racional de novos radiofármacos

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Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver

Cited by 93 publications

References 19 publications

Bis(phenylethylamide) Derivatives of Gd‐DTPA as Potential Receptor‐Specific MRI Contrast Agents

Bis(phenylethylamide) Derivatives of Gd‐DTPA as Potential Receptor‐Specific MRI Contrast Agents

Enhanced tumor MR imaging with gadolinium‐loaded polychelating polymer‐containing tumor‐targeted liposomes

Polymeric micelles and molecular modeling applied to the development of radiopharmaceuticals

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