Gadolinium(III)-Incorporated Nanosized Mesoporous Silica as Potential Magnetic Resonance Imaging Contrast Agents

Abstract

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using longchain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, 29 Si-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r 1 and r 2 , than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

“…[8][9][10] Magnetic resonance imaging (MRI) has become a powerful noninvasive tool in the clinical diagnosis of disease and in vivo imaging through the ability to acquire 3D tomographic images with high spatial resolution. [ 11,12 ] Contrast agents are an important consideration when using MRI; however, most clinical contrast agents such as gadolinium chelated diethylenetriaminopentaacetic acid (Gd-DTPA) are small, nontargeted compounds. As such, they sometimes passively distribute into the interstitial spaces of tissues and organs, resulting in an insuffi cient signal enhancement.…”

Squarely Mesoporous and Functional Nanocomposites by Self‐Directed Assembly of Organosilane

“…[1][2][3][4] These porous materials are normally synthesized by co-assembling bridged silsesquioxanes and surfactants, followed by the removal of surfactant molecules. [2][3][4] Self-directed assembly of bridged silsesquioxanes which exploits non-covalent interactions generally produces mesoscopically ordered lamellar solid materials.…”

Fe_2O_3 and Gd_2O_3 Nanoparticles Embedded in Mesoporous Silica: Magnetic Properties Comparison

“…Due to porous structure of the silica, water can freely move in and out of the matrix and simultaneously, it can be carrier of metal nanoparticles. Additionally, the nontoxic silica can be easily derived and targeted contrast agents can be synthesized [3].…”