Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

Zhang, Guilong; Du, Rongguang; Zhang, Lele; Cai, Dongqing; Sun, Xiao; Zhou, Yong; Zhou, Ji; Qian, Junchao; Zhong, Kai; Zheng, Kang; Kaigler, Darnell; Liu, Wenqing; Zhang, Xin; Zou, Duohong; Wu, Zhengyan

doi:10.1002/adfm.201502868

Cited by 66 publications

(45 citation statements)

References 46 publications

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“…Similarly, Li and co‐workers synthesized core‐shell Fe 3 O 4 @Gd 2 O 3 nanocubes whose r 1 value and r 2 / r 1 ratio were 45.24 m m −1 s −1 and 4.1, respectively ( B 0 = 1.5 T) 24. Furthermore, thermal decomposition technique was employed in synthesizing Gd‐doped iron oxide nanoparticles (NPs) with r 1 value of 7.87 m m −1 s −1 and r 2 / r 1 ratio of 23.2 ( B 0 = 9.4 T) 25. Put together, with respect to the effect of B 0 , the aforementioned strategies yielded Gd‐containing T 1 contrast agents that exhibit appreciably high r 1 values.…”

Section: Introductionsupporting

confidence: 44%

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Wei

Jiang

Pan

et al. 2020

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The market of available contrast agents for clinical magnetic resonance imaging (MRI) has been dominated by gadolinium (Gd) chelates based T1 contrast agents for decades. However, there are growing concerns about their safety because they are retained in the body and are nephrotoxic, which necessitated a warning by the U.S. Food and Drug Administration against the use of such contrast agents. To ameliorate these problems, it is necessary to improve the MRI efficiency of such contrast agents to allow the administration of much reduced dosages. In this study, a ten‐gram‐scale facile method is developed to synthesize organogadolinium complex nanoparticles (i.e., reductive bovine serum albumin stabilized Gd‐salicylate nanoparticles, GdSalNPs‐rBSA) with high r1 value of 19.51 mm−1 s−1 and very low r2/r1 ratio of 1.21 (B0 = 1.5 T) for high‐contrast T1‐weighted MRI of tumors. The GdSalNPs‐rBSA nanoparticles possess more advantages including low synthesis cost (≈0.54 USD per g), long in vivo circulation time (t1/2 = 6.13 h), almost no Gd3+ release, and excellent biosafety. Moreover, the GdSalNPs‐rBSA nanoparticles demonstrate excellent in vivo MRI contrast enhancement (signal‐to‐noise ratio (ΔSNR) ≈ 220%) for tumor diagnosis.

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Section: Introductionsupporting

confidence: 44%

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Wei

Jiang

Pan

et al. 2020

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“…The conjugation of RGD2 resulted in a lower r 1 value and higher r 2 / r 1 ratio, which can be ascribed to the slight aggregation of the nanoparticles induced by RGD2 conjugation. Overall, as measured by a 1.5 T clinical MRI scanner system, the r 1 values of FeGd‐HN3 and FeGd‐HN3‐RGD2 (>70.0 mM −1 s −1 ) are much higher than the reported T 1 ‐weighted MRI contrast agents and Magnevist (a commonly used T 1 ‐weighted MRI contrast agent on the market). The corresponding r 2 / r 1 ratios of FeGd‐HN3 and FeGd‐HN3‐RGD2 (<2.0) are lower than most of the reported T 1 ‐weighted MRI contrast agents and comparable to that of the Magnevist.…”

Section: Methodsmentioning

confidence: 81%

“…The r 1 value was 4.2 mM −1 s −1 and r 2 / r 1 ratio was 4.1 ( B 0 = 3.0 T) . Zhang et al synthesized Gd‐doped iron oxide nanoparticles (GION) based on a thermal decomposition method, whose r 1 value was 7.87 mM −1 s −1 and r 2 / r 1 ratio was 23.2 ( B 0 = 9.4 T) . Jung et al prepared Gd(III)‐DOTA‐modified sonosensitive liposomes using Gd(III)‐DOTA‐1,2‐distearoyl‐ sn ‐glycero‐3‐phosphoethanolamine lipid.…”

Section: Methodsmentioning

confidence: 99%

Dotted Core–Shell Nanoparticles for T₁‐Weighted MRI of Tumors

et al. 2018

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Gd-based T -weighted contrast agents have dominated the magnetic resonance imaging (MRI) contrast agent market for decades. Nevertheless, they are reported to be nephrotoxic and the U.S. Food and Drug Administration has issued a general warning concerning their use. In order to reduce the risk of nephrotoxicity, the MRI performance of the Gd-based T -weighted contrast agents needs to be improved to allow a much lower dosage. In this study, novel dotted core-shell nanoparticles (FeGd-HN3-RGD2) with superhigh r value (70.0 mM s ) and very low r /r ratio (1.98) are developed for high-contrast T -weighted MRI of tumors. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and histological analyses show good biocompatibility of FeGd-HN3-RGD2. Laser scanning confocal microscopy images and flow cytometry demonstrate active targeting to integrin α β positive tumors. MRI of tumors shows high tumor ΔSNR for FeGd-HN3-RGD2 (477 ± 44%), which is about 6-7-fold higher than that of Magnevist (75 ± 11%). MRI and inductively coupled plasma results further confirm that the accumulation of FeGd-HN3-RGD2 in tumors is higher than liver and spleen due to the RGD2 targeting and small hydrodynamic particle size (8.5 nm), and FeGd-HN3-RGD2 is readily cleared from the body by renal excretion.

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“…With increased molar concentration of Gd in the precursor solution, we observed increases in T 1 contrast and longitudinal relaxivity values (Figure a). The GdIO NPs exhibited an r 1 value of 1.55 m m –1 s –1 , which is higher than that for Gd 0.06 Fe 2.94 O 4 with the same concentration . The obtained r 1 value for Gd 0.06 Fe 2.94 O 4 is also higher than those for conventional Gd oxide NPs .…”

Section: Resultsmentioning

confidence: 69%

Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy

et al. 2016

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A facile polyol approach for preparing low‐Curie‐temperature (TC) gadolinium‐doped iron oxide nanoparticles (GdIO NPs) for targeted magnetic hyperthermia and chemotherapy coupled with T1–T2 dual‐model magnetic resonance (MR) imaging (where T1 and T2 are the longitudinal and transverse relaxation times, respectively) is reported. A small amount of Gd doping decreases the TC of iron oxide down to about 400 K. In the presence of ethanolamine, controlled polyol synthesis leads to the formation of low‐TC, highly magnetic (52.87 emu g–1), and size‐controlled (ca. 10 nm) GdIO NPs. A further conjugation with folate and a chemotherapeutic drug has been developed, and the whole system is used for in vitro magneto‐chemotherapy (magnetic hyperthermia and chemotherapy) for cancer treatment. The synthesized GdIO NPs are stable colloids that are hemocompatible and cytocompatible over a wide concentration range and have a high affinity towards cancer cells. The release of a chemotherapeutic drug from the GdIO NPs significantly affects cancer cell viability, and the T1–T2 dual‐model magnetic resonance enhances bioimaging in a breast cancer cell model. We suggest that the chemotherapeutic‐drug‐conjugated GdIO NPs have great potential for cell targeting and magnetic resonance imaging in cancer magneto‐chemotherapy.

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Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

Cited by 66 publications

References 46 publications

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Dotted Core–Shell Nanoparticles for T₁‐Weighted MRI of Tumors

Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy

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Gadolinium‐Doped Iron Oxide Nanoprobe as Multifunctional Bioimaging Agent and Drug Delivery System

Cited by 66 publications

References 46 publications

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Ten‐Gram‐Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

Dotted Core–Shell Nanoparticles for T1‐Weighted MRI of Tumors

Superparamagnetic Gadolinium Ferrite Nanoparticles with Controllable Curie Temperature – Cancer Theranostics for MR‐Imaging‐Guided Magneto‐Chemotherapy

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Dotted Core–Shell Nanoparticles for T₁‐Weighted MRI of Tumors