Gadolinium embedded iron oxide nanoclusters as T1–T2 dual-modal MRI-visible vectors for safe and efficient siRNA delivery

Wang, Xiaoyong; Zhou, Zijian; Wang, Zhiyong; Xue, Yunxin; Zeng, Yun; Gao, Jinhao; Zhu, Lei; Zhang, Xianzhong; Liu, Gang; Chen, Xiaoyuan

doi:10.1039/c3nr02797j

Cited by 47 publications

(35 citation statements)

References 33 publications

(24 reference statements)

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“…These Gdembedded iron oxide nanoparticles also provided a platform for gene delivery with MRI monitoring. 261 Therefore, doping Gd 3+ into iron oxide nanoparticles is an effective route for the design of T 1 and T 2 CAs, which was further verified by Ye and coworkers. 262 They synthesized PEGylated Gd-doped iron oxide nanoparticles via the polyol route, with r 1 and r 2 of 65.9 and 73.9 mM −1 s −1 , respectively.…”

Section: Lanthanide Nanoparticles For T 1 and T 2 Dual-mode Mrimentioning

confidence: 77%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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Section: Lanthanide Nanoparticles For T 1 and T 2 Dual-mode Mrimentioning

confidence: 77%

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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“…This property can be advantageously exploited for MRI [25][26] producing T 1 -T 2 dual modal magnetic resonance imaging (MRI) contrast agents. [27][28][29][30][31][32][33] Gadolinium-based agents still have relatively low sensitivity, so a high dose of contrast agents should be used. In addition, free gadolinium ions 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 4 leached from the complexes can have toxic side effects such as nephrogenic systemic fibrosis (NSF).…”

Section: Introductionmentioning

confidence: 99%

Doped-Iron Oxide Nanocrystals Synthesized by One-Step Aqueous Route for Multi-Imaging Purposes

et al. 2019

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New doped inorganic nanocrystals (NC) consisting on iron oxide and other metal integrated into the structure have been synthesized in one-step by adapting the oxidant precipitation synthesis route for magnetite. Different metals have been chosen to confer extra and unique properties to the resulting magnetic heteronanostructure: Co and Gd for enhancing transversal and longitudinal relaxivities for Magnetic Resonance Imaging (MRI), and Bi and Au for achieving X-Ray absorption for CT imaging. Apart of that, gold optical properties are interesting for photothermal therapy and iron oxides for magnetic hyperthermia. All metals have been incorporated during the synthesis to the magnetite structure in different ways: by forming a solid solution, by modifying the surface of the NCs or by cocrystallization with the magnetite. The nanostructure formed in each case depends on the ionic radius of the secondary metal ion and the solubility of its hydroxide that control the co-precipitation in the initial steps of the reaction.Magnetic properties and imaging capabilities of the heteronanostructures have been analyzed as a function of the element distribution. Due to the synergistic combination of the different element properties, these magnetic heteronanostructures have great potential for biomedical applications.

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“…12 Here, we focus on the composite material gadolinium-doped magnetite (Gd:Fe 3 O 4 ). Gd doping or labelling has been shown to improve the MRI contrast of iron oxide NPs via T 1 enhancement, [13][14][15][16][17] whereas the MH properties of gadolinium-doped magnetite have received much less attention. 1,18 Whilst doping ions into MNPs is simple in principle, establishing reproducible synthetic procedures can be difficult.…”

Section: Introductionmentioning

confidence: 99%