Gadolinium‐based contrast agents and nephrotoxicity

Morcos, Sameh K.

doi:10.1002/ccd.20929

Cited by 5 publications

(2 citation statements)

References 52 publications

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“…The lanthanide ion Gd 3+ is by far the most frequently chosen MRI contrast agent because it couples a large magnetic moment with a long electron spin relaxation time . However, the free Gd 3+ ion has been shown to be toxic in both in vitro and in vivo studies, − as its radial size is approximately equal to that of the Ca 2+ ion allowing it to disrupt Ca-mediated signaling. Therefore, it must be sequestered by chelation or encapsulation − for in vivo use.…”

Section: Introductionmentioning

confidence: 99%

Colloidal Amphiphile Self-Assembly Particles Composed of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging

et al. 2009

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Gadolinium oleate has been added at various concentrations to a Myverol inverse bicontinuous cubic phase forming system, and the potential of these systems as magnetic resonance imaging (MRI) contrast agents has been investigated. Differential scanning calorimetry (DSC), small-angle X-ray scattering (SAXS), and cryo-transmission electron microscopy (cryo-TEM) measurements on the Gd oleate/Myverol systems indicate that Gd oleate is at least partially incorporated within the cubic phase of Myverol. However, at Gd oleate concentrations greater than 1 wt %, partial phase separation of the system may occur with the formation of a Gd-oleate-rich lamellar phase as well as the cubic phase. Bulk Gd oleate/Myverol mixtures can be dispersed into stable colloidal dispersions. SAXS and cryo-TEM measurements on these dispersions indicate that the presence of Gd oleate in the Myverol system prevents the formation of cubosomes from the bulk cubic phase. Instead, the dispersion consists of putative Gd-oleate-rich nonswelling lamellar nanoparticles as well as colloidal particles lacking ordered internal structure. In vitro studies on these dispersions demonstrated that the relaxivity of select Gd oleate/Myverol systems is much higher than that of pure Gd oleate, exemplifying the promise of this system type for magnetic resonance imaging. The highest water proton relaxivities (r(1) = 34.2 mM(-1) s(-1) and r(2) = 27.3 mM(-1) s(-1) at 20 MHz and room temperature) were obtained at a Gd oleate loading concentration of 1 wt %, with a subsequent decrease in relaxivity with increasing Gd oleate concentration. These maximum relaxivities compare favorably with the relaxivities for the commercial contrast agent, Magnevist (r(1) = 4.91 mM(-1) s(-1) and r(2) = 6.26 mM(-1) s(-1) at 20 MHz and room temperature).

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Section: Introductionmentioning

confidence: 99%

Colloidal Amphiphile Self-Assembly Particles Composed of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging

et al. 2009

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“…The paramagnetic gadolinium(III) ion significantly reduces both the longitudinal and transverse proton relaxation times ( T 1 and T 2 ) relative to that of pure water . Because the free gadolinium(III) ion has been shown to be toxic in both in vivo and in vitro studies, − it is generally sequestered by chelation or encapsulation − in biomedical applications. Commercial contrast agents such as Magnevist, which is the gadolinium complex of diethylenetriamine pentaacetic acid, are all nonspecific and suffer from the shortcomings of limited resolution and relatively low inherent sensitivity .…”

Section: Introductionmentioning

confidence: 99%

Lanthanide Phytanates: Liquid-Crystalline Phase Behavior, Colloidal Particle Dispersions, and Potential as Medical Imaging Agents

et al. 2009

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Lanthanide salts of phytanic acid, an isoprenoid-type amphiphile, have been synthesized and characterized. Elemental analysis and FTIR spectroscopy were used to confirm the formed product and showed that three phytanate anions are complexed with one lanthanide cation. The physicochemical properties of the lanthanide phytanates were investigated using DSC, XRD, SAXS, and cross-polarized optical microscopy. Several of the hydrated salts form a liquid-crystalline hexagonal columnar mesophase at room temperature, and samarium(III) phytanate forms this phase even in the absence of water. Select lanthanide phytanates were dispersed in water, and cryo-TEM images indicate that some structure has been retained in the dispersed phase. NMR relaxivity measurements were conducted on these systems. It has been shown that a particulate dispersion of gadolinium(III) phytanate displays proton relaxivity values comparable to those of a commercial contrast agent for magnetic resonance imaging and a colloidal dispersion of europium(III) phytanate exhibits the characteristics of a fluorescence imaging agent.

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Current awareness: Pharmacoepidemiology and drug safety

2007

Pharmacoepidemiology and Drug

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 20 sections: 1 Reviews; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Teratogens/fetal exposure; 20 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

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Gadolinium‐based contrast agents and nephrotoxicity

Cited by 5 publications

References 52 publications

Colloidal Amphiphile Self-Assembly Particles Composed of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging

Colloidal Amphiphile Self-Assembly Particles Composed of Gadolinium Oleate and Myverol: Evaluation as Contrast Agents for Magnetic Resonance Imaging

Lanthanide Phytanates: Liquid-Crystalline Phase Behavior, Colloidal Particle Dispersions, and Potential as Medical Imaging Agents

Current awareness: Pharmacoepidemiology and drug safety

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