Gadolinium-based bimodal probes to enhance T1-Weighted magnetic resonance/optical imaging

Yang, Chang‐Tong; Hattiholi, Aishwarya; Selvan, Subramanian Tamil; Yan, Sean Xuexian; Fang, Wei; Chandrasekharan, Prashant; Koteswaraiah, Podili; Herold, Christian; Gulyás, Balázs; Aw, Swee Eng; He, Tao; Ng, David Chee Eng; Parameswaran, P.

doi:10.1016/j.actbio.2020.03.047

Cited by 40 publications

(22 citation statements)

References 165 publications

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“…Semiconducting quantum dot (QD)- and magnetic nanoparticle (NP)-based bioconjugates have been widely employed as either labeling/molecular imaging agents − or therapeutic carriers − for cancer nanomedicine. Conversely, noble metal NPs, − doped nanocrystals, , and upconversion NPs have received a great deal of interest as alternative nanobioconjugates for sensing, imaging, and drug delivery applications.…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Patel

Nadar

Umapathy

et al. 2020

ACS Appl. Nano Mater.

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Herein, we report facile theranostic platinum nanoparticles (PtNPs) conjugated to an anticancer drug, doxorubicin (DOX), in unraveling the inhibition of a cell survival PI3K/AKT (phosphatidylinositol 3-kinase/protein kinase B) signaling pathway in MCF-7 and MDA-MB-231 human breast cancer cells. The significant features of our DOX@PtNPs as a theranostic platform are as follows: (i) drug release studies showed a progressive pH-dependent delivery; (ii) in vitro studies of DOX@PtNPs displayed a relatively higher cytotoxicity to breast cancer cells compared to unconjugated PtNPs and DOX; (iii) intracellular drug release studies showed a specific binding of DOX@PtNPs and their release within the cytoplasm and perinuclear region; (iv) DOX@PtNPs induced the apoptosis of cancer cells by DNA damage via the generation of elevated levels of reactive oxygen species and decreased mitochondrial membrane potential (ΔΨm), as evidenced by fluorescence microscopic studies; and (v) DOX@PtNPs inhibited the PI3K/AKT signaling pathway in breast cancer cells by activating PTEN, a tumor suppressor gene. The induced mitochondrial-dependent apoptotic pathway led to the activation of downstream caspases. Finally, our findings illustrate that DOX@PtNPs may serve as a better theranostic agent for cancer nanomedicine.

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Section: Introductionmentioning

confidence: 99%

Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Patel

Nadar

Umapathy

et al. 2020

ACS Appl. Nano Mater.

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“…Compared with the negative contrast agent, Gd-DTPA can change the T1 signal of the target tissue from black to white (light-on effect) and improve the recognition accuracy. 30 Before IGP@P NP injection, the T1 signal at the tumor site in the mice was iso-signal compared with the adjacent muscle tissue. Three hours and 6 h after the injection of IGP@P NPs, we observed a slightly uneven rise in the T1 signal in the tumor area compared with the adjacent muscle tissue, and the SNR values were statistically higher at both of these time points than the SNR at 0 h ( P < 0.01), confirming the targeting effects of a small portion of the NPs to the tumors ( Figure 7C and E ).…”

Section: Resultsmentioning

confidence: 99%

Theranostic Nanoplatform with Sequential SDT and ADV Effects in Response to Well-Programmed LIFU Irradiation for Cervical Cancer

Zhou¹,

Hou²,

Liu³

et al. 2021

IJN

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Background: Some patients with cervical cancer have the need to preserve fertility; therefore, a minimally invasive treatment option that can effectively inactivate tumors in these patients is necessary. Methods: In this paper, we designed and prepared nanoparticles (NPs) carrying IR780 and perfluorohexane (PFH) and characterized their properties. We focused on the promotion of programmed low-intensity focused ultrasound (LIFU) irradiation on the penetration and treatment of cervical cancer. First we used penetration-enhancing LIFU irradiation to promote the penetration of the NPs into 3D multicellular tumor spheroids (MCTSs) and tumors in tumor-bearing nude mice. Then we used re-therapeutic LIFU irradiation to achieve antitumor effects in vitro and in vivo. Photoacoustic (PA) and magnetic resonance (MR) imaging were used to monitor and evaluate the targeting and therapeutic effects of these NPs on tumor tissues. Results:The NPs prepared in this paper exhibited high affinity for HeLa cells, and can selectively achieve mitochondrial localization in the cell due to IR780 assistance. The penetration-enhancing LIFU irradiation have the ability to promote the penetration of the NPs into cervical cancer models in vivo and in vitro. Under LIFU irradiation, the cytotoxic reactive oxygen species (ROS) produced by IR780 during the first half of the re-therapeutic LIFU irradiation and the physical acoustic droplet vaporization (ADV) effect after PFH phase transition during the second half of the re-therapeutic LIFU irradiation can achieve synergistic minimally invasive treatment of tumors, which can be visualized and evaluated by PA and MR imaging in vivo. Conclusion:Well-programmed LIFU irradiation can promote NP penetration into deep tumor tissue and achieve antitumor effects simultaneously. Linking ROS + ADV effects can induce cell coagulation necrosis and lead to a comprehensive, long-term impact on tumor tissue, providing a conceptual theranostic nanoplatform for cervical cancer.

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“…Liposome-nanoparticle hybrids that include metallic components such as: gold nanoparticles [75,81] or gadolinium nanoparticles (GdNPs) [63,82,83], and ultrasuperand superparamagnetic iron oxide nanoparticles (SPIONs)-called magnetoliposomes (MLs) [60,84,85]-can serve in the visualization of the cancer tissues using CT and MRI. Liposome-based CAs incorporating gadolinium were the first introduced nanostructure that has been widely used in various systems [86][87][88]. Scientists constantly broaden their research in terms of the administration of newly synthesized contrast agents containing liposomes and metallic nanoparticles into different types of cancer tissues.…”

Section: Medical Imagingmentioning

confidence: 99%

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

Musielak

Potoczny

Boś-Liedke

et al. 2021

IJMS

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Nanotechnology has introduced a new quality and has definitely developed the possibilities of treating and diagnosing various diseases. One of the scientists’ interests is liposomes and metallic nanoparticles (LipoMNPs)—the combination of which has introduced new properties and applications. However, the field of creating hybrid nanostructures consisting of liposomes and metallic nanoparticles is relatively little understood. The purpose of this review was to compile the latest reports in the field of treatment and medical imaging using of LipoMNPs. The authors focused on presenting this issue in the direction of improving the used conventional treatment and imaging methods. Most of all, the nature of bio-interactions between nanostructures and cells is not sufficiently taken into account. As a result, overcoming the existing limitations in the implementation of such solutions in the clinic is difficult. We concluded that hybrid nanostructures are used in a very wide range, especially in the treatment of cancer and magnetic resonance imaging. There were also solutions that combine treatments with simultaneous imaging, creating a theragnostic approach. In the future, researchers should focus on the description of the biological interactions and the long-term effects of the nanostructures to use LipoMNPs in the treatment of patients.

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Gadolinium-based bimodal probes to enhance T1-Weighted magnetic resonance/optical imaging

Cited by 40 publications

References 165 publications

Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Doxorubicin-Conjugated Platinum Theranostic Nanoparticles Induce Apoptosis via Inhibition of a Cell Survival (PI3K/AKT) Signaling Pathway in Human Breast Cancer Cells

Theranostic Nanoplatform with Sequential SDT and ADV Effects in Response to Well-Programmed LIFU Irradiation for Cervical Cancer

The Combination of Liposomes and Metallic Nanoparticles as Multifunctional Nanostructures in the Therapy and Medical Imaging—A Review

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