Gabosines P and Q, new carbasugars from Streptomyces sp. and their α-glucosidase inhibitory activity

Wei, Jing; Liu, Lingli; Dong, Shuai; Li, Hui; Tang, Dan; Zhang, Qiang; Xue, Qiao; Gao, Jin‐Ming

doi:10.1016/j.bmcl.2016.09.021

Cited by 15 publications

(18 citation statements)

References 23 publications

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“…Recently, several compounds with similar skeleton had also been isolated from the genus Phoma , Eupenicillium , and Aspergillus . Particularly, this group of polyoxygenated cyclohexenoids also occur in genus Streptomyces . Nevertheless, in addition to contribute more new homologues to this type of compounds, our current work indicates that these cyclohexenoids might be a promising source for new α-glycosidase inhibitors.…”

Section: Resultsmentioning

confidence: 74%

Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi

Huang

Jiang

et al. 2018

J. Agric. Food Chem.

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Seven new polyoxygenated cyclohexenoids, namely, phomopoxides A-G (1-7), were isolated from the fermentation broth extract of an endophytic fungal strain Phomopsis sp. YE3250 from the medicinal plant Paeonia delavayi Franch. The structures of these compounds were established by spectroscopic interpretation. The absolute configurations of compounds 1 and 4 were confirmed by X-ray crystallographic analysis and chemical derivative approach. All isolated compounds showed weak cytotoxic activities toward three human tumor cell lines (Hela, MCF-7, and NCI-H460) and weak antifungal activities against five pathogenic fungi (Candida albicans, Aspergillus niger, Pyricularia oryzae, Fusarium avenaceum, and Hormodendrum compactum). In addition, compounds 1-7 showed a promising α-glycosidase inhibitory activity with IC values of 1.47, 1.55, 1.83, 2.76, 2.88, 3.16, and 2.94 mM, respectively, as compared with a positive control of acarbose (IC = 1.22 mM).

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Section: Resultsmentioning

confidence: 74%

Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi

Huang

Jiang

et al. 2018

J. Agric. Food Chem.

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“…8 (Qinling Mountains, Shaanxi, China). Gabosine P ( 124 ) showed α-glucosidase inhibition with an IC 50 value of 9.07 μM, more potent than acarbose (663.28 μM) (Wei et al, 2016a ). 13α-Hydroxy-4-ethyl milbemycin β 3 ( 125 ), 13α-hydroxy-25-ethylmilbemycin β 3 ( 126 ), and 13α-hydroxymilbemycin β 3 ( 127 ), three novel β-class milbemycins, were obtained from a fermentation broth of the genetically engineered strain Streptomyces avermitilis MHJ1011.…”

Section: Terrestrial Microorganismsmentioning

confidence: 99%

Natural Products Research in China From 2015 to 2016

et al. 2018

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“…This section was performed according to our previous publication [15,16]. MMFF and DFT calculations were run with Spartan 10 (Wave function Inc., Irvine, CA) with standard parameters and convergence criteria.…”

Section: Extraction and Isolationmentioning

confidence: 99%

Chaetolactone, A Skeletally New Cyclopentenone from Chaetomium sp. C521

Han

Zhou

et al. 2018

Natural Product Communications

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Chaetolactone, a new polyketide with an unprecedented carbon skeleton, was constructed by Chaetomium sp. C521. Its structure was characterized by a combination of detailed spectroscopic analysis and ECD method, which facilitated the establishment of the absolute configuration for chaetolactone. The new compound was tested for anti-phytopathogenic activity against Botrytis cinerea, Alternaria solani, Gibberella saubinettii, and Magnaporthe oryzae, but exhibited negligible inhibition at a concentration of 20 μM.

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Gabosines P and Q, new carbasugars from Streptomyces sp. and their α-glucosidase inhibitory activity

Cited by 15 publications

References 23 publications

Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi

Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi

Natural Products Research in China From 2015 to 2016

Chaetolactone, A Skeletally New Cyclopentenone from Chaetomium sp. C521

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