Gabapentin Versus Vigabatrin as First Add‐On for Patients with Partial Seizures That Failed to Respond to Monotherapy: A Randomized, Double‐Blind, Dose Titration Study

Lindberger, Martin; Ålenius, Martin; Frisén, Lars; Johannessen, Svein I.; Larsson, Sirkku; Malmgren, Kristina; Tomson, Torbjörn

doi:10.1111/j.1528-1157.2000.tb04607.x

Cited by 48 publications

(36 citation statements)

References 13 publications

(9 reference statements)

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“…131 The remaining study was discontinued prematurely and failed to recruit the required number of participants. 132 This study also found baseline differences between treatment groups in the duration of epilepsy and in some cases doses of GBP and VGB exceeded the recommended limit.…”

Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 67%

“…61,131,132 Two studies used treatment periods of 24 weeks 131,132 and the third followed treatment over a period of 18 months. 61 Two trials included patients with partial seizures 61,132 and the third included patients with partial or generalised seizures. 131 Two trials compared GBP with LTG 61,131 and two compared GBP with VGB.…”

Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 99%

“…131 Two trials compared GBP with LTG 61,131 and two compared GBP with VGB. 61,132 Two of the studies used an open-label design. 61,131 One study was only reported as an abstract and it was not possible to assess fully the quality of the study.…”

Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 99%

“…After further examination, 616 of the papers were excluded for the following reasons: literature reviews/background (175); systematic reviews/metaanalyses not meeting criteria (132); not RCT (118); not relevant intervention (9); not relevant population (18); not relevant outcomes (4); dose comparison studies (19); unavailable publications [104; consisting of NRR records of registered trials in progress (92) and unable to obtain the paper (12)]; methodology papers (6); follow-up studies (19); unsure (4); ongoing studies (4); and nonEnglish studies (4). For the 12 papers not obtainable, these were from six journal issues, and comprised conference abstracts (9), foreign language papers (1) and background papers (2).…”

Section: Excluded Studiesmentioning

confidence: 99%

“…61,[131][132][133] The remaining studies all compared newer AEDs with placebo. Forty-six studies used a parallel design and 26 were crossover studies.…”

Section: [Data Have Been Designated Commercial-inconfidence and Have mentioning

confidence: 99%

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Clinical effectiveness, tolerability and cost-effectiveness of newer drugs for epilepsy in adults: a systematic review and economic evaluation

Wilby¹,

Kainth²,

Hawkins³

et al. 2005

Health Technol Assess

199

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Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 67%

Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 99%

Section: Newer Drugs Versus Newer Drugs a Seizure Frequency I Seizumentioning

confidence: 99%

Section: Excluded Studiesmentioning

confidence: 99%

“…61,[131][132][133] The remaining studies all compared newer AEDs with placebo. Forty-six studies used a parallel design and 26 were crossover studies.…”

Section: [Data Have Been Designated Commercial-inconfidence and Have mentioning

confidence: 99%

See 3 more Smart Citations