Gabapentin: pharmacology and its use in pain management

Rose, Michael; Kam, P. C. A.

doi:10.1046/j.0003-2409.2001.02399.x

Cited by 442 publications

(316 citation statements)

References 110 publications

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“…Pregabalin has analgesic, anticonvulsant, and anxiolytic effects [5,6]. Several studies have demonstrated the efficacy of oral pregabalin on post-operative analgesia and reduction of parenteral analgesics [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Samal

Pattnaik

Swain

et al. 2017

Asian J Pharm Clin Res

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Objectives: The airway instrumentation of direct laryngoscopy and tracheal intubation is powerful noxious stimuli that should be attenuated by appropriate premedication, smooth induction, and rapid intubation. This study compared the efficacy intravenous dexmedetomidine and oral pregabalin premedication for attenuation of hemodynamic pressor response to laryngoscopy and intubation.Methods: A total of 60 patients of age group 20-50 years scheduled for elective surgeries under general anesthesia with American Society of Anesthesiologists physical Status I and II were divided into two groups each of 30. Group D received intravenous dexmedetomidine 1 mcg/kg over 10 minutes before induction, and Group P received oral pregabalin 150 mg 1 hr before intubation. Parameters observed were heart rate (HR) and mean arterial pressure (MAP) at baseline, after induction, immediately after intubation and then 5, 10, 15, and 30 minutes thereafter.Results: Attenuation of HR in group dexmedetomidine (78.12±10.0/minutes) immediately after intubation was statistically significant than group pregabalin (89.76±10.45/minutes). MAP significantly (p<0.05) decreased after intubation with dexmedetomidine. As compared to oral pregabalin, attenuation of HR and MAP was statistically significant till 30 minutes after intubation with intravenous dexmedetomidine. Conclusion:Intravenous dexmedetomidine 1 µg/kg is more effective than oral pregabalin 150 mg in attenuating hemodynamic response to laryngoscopy and orotracheal intubation.

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Section: Introductionmentioning

confidence: 99%

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Samal

Pattnaik

Swain

et al. 2017

Asian J Pharm Clin Res

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“…GBP is effective for neuropathic pain, diabetic neuropathy, postherpetic neuralgia and reflex sympathetic dystrophy (7). GBP has antihyperalgesic actions that selectively affect central sensitization (8). Over the past eight years, many trials have examined the efficacy of GBP for the treatment of early postsurgical pain.…”

mentioning

confidence: 99%

Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty

Clarke¹,

Pereira²,

Kennedy³

et al. 2009

Acute Pain

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“…This is one reason why we chose to use pregabalin instead of gabapentin, which has a lower bioavailability at high doses and reaches peak plasma levels three times more slowly. 18 We therefore consider this dose sufficient to show a clinically relevant interaction, if it existed. Finally, the statistical method used in the present study is robust.…”

Section: Discussionmentioning

confidence: 99%

Preoperative pregabalin does not reduce propofol ED50: a randomized controlled trial

Moreau-Bussière

Gaulin

Gagnon

et al. 2013

Can J Anesth/J Can Anesth

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Background In many studies, gabapentinoids, such as pregabalin, have been shown to reduce preoperative anxiety. This anxiolysis is often accompanied by sedation, one of the most frequent side effects of pregabalin. We hypothesized that pregabalin taken preoperatively could reduce propofol requirements for induction of general anesthesia. Methods A randomized double-blind placebo-controlled trial was conducted after approval by the local ethics committee. Fifty women aged 18-40 yr, American Anesthesiologists Society physical status I and II, and scheduled to undergo elective laparoscopic gynecologic procedures were enrolled after written consent. Treatment group patients were given pregabalin 150 mg po one hour before surgery while patients in the control group received a placebo. The primary outcome was the propofol dose required to achieve a targeted anesthetic depth in 50% of the population, i.e., effective dose (ED) 50 Conclusions Preoperative pregabalin does not reduce propofol requirements in a population of healthy young women undergoing laparoscopic gynecologic procedures. This study failed to show a pre-induction anxiolytic effect of pregabalin in such a population.

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Gabapentin: pharmacology and its use in pain management

Cited by 442 publications

References 110 publications

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Dexmedetomidine Versus Oral Pregabalin to Attenuate Hemodynamic Response to Laryngoscopy and Orotracheal Intubation: A Comparative Study

Gabapentin decreases morphine consumption and improves functional recovery following total knee arthroplasty

Preoperative pregabalin does not reduce propofol ED50: a randomized controlled trial

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