Gabapentin Augmentation for Fluoxetine-Treated Patients With Obsessive-Compulsive Disorder

Corá-Locatelli, Gabriela; Greenberg, Benjamin D.; Martin, Juliet; Murphy, Dennis L.

doi:10.4088/jcp.v59n0907d

Cited by 45 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reduced SICI could result either from less GABA(A)ergic inhibition or more glutamate-mediated excitation of the cortical output neurons in OCD than in healthy individuals. These data are consistent with a preliminary finding that medication modulating the GABA/glutamate balance might have therapeutic effects in OCD [6].…”

Section: Discussionsupporting

confidence: 92%

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Khedr

Elbeh

Elserogy

et al. 2016

Neurophysiologie Clinique/Clinical Neurophysiology

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Khedr

Elbeh

Elserogy

et al. 2016

Neurophysiologie Clinique/Clinical Neurophysiology

View full text Add to dashboard Cite

“…There is limited evidence supporting the use of gabapentin as an anxiolytic, with one small, open study of patients with obsessive-compulsive disorder and a case series of four patients with primary anxiety disorders who experienced clinical improvement with gabapentin [79,80]. The use of gabapentin for neuropathic pain has been demonstrated [81,82].…”

Section: Anticonvulsantsmentioning

confidence: 99%

Cancer pain and anxiety

Thielking

2003

Current Science Inc

View full text Add to dashboard Cite

Anxiety and pain can be understood with a multidimensional framework that accounts for somatic, emotional, cognitive, and behavioral aspects of these conditions. Patients who have cancer or treatment-related pain are more likely to be anxious than cancer patients without pain. Patients with cancer pain and anxiety cause difficult diagnostic dilemmas because some degree of anxiety is a normal response to having a severe medical illness. Furthermore, the somatic symptoms of anxiety often overlap with symptoms related to underlying disease processes or treatment effects. The degree of disruption in a patient's life often is the critical factor in distinguishing normal from maladaptive anxiety. Making an accurate diagnosis will help guide anxiety treatment and screening instruments can facilitate the recognition of those patients in need of further assessment. The relationship between pain and anxiety is complex and bidirectional, with interactions occurring on physiologic and psychologic levels. There are a variety of psychopharmacologic, psychotherapeutic, and complementary/alternative treatments available. A comprehensive approach to care includes these approaches in an individualized way. Terminal sedation is examined as a compassionate option for relieving intractable distress at the end of life.

show abstract

“…Cora-Locatelli et al [62] presented a case report of five patients with obsessive-compulsive disorder (OCD) who all were partial responders to fluoxetine monotherapy. Patients were adjunctively treated with gabapentin at a dosage of 900 to 3600 mg/d for 6 weeks.…”

Section: Gabapentinmentioning

confidence: 99%

Anticonvulsants in anxiety disorders

Kinrys

Wygant²

2005

Curr Psychiatry Rep

View full text Add to dashboard Cite

Anticonvulsant drugs have shown promising results in the treatment of mood disorders, leading to the investigation of their potential efficacy in other psychiatric disorders. Numerous case reports, open-label trials, and placebo- controlled trials investigating the use of anticonvulsants in the treatment of anxiety disorders have yielded broad and varying results. Generally, these studies have indicated a potential role for anticonvulsants in the treatment of anxiety as monotherapy or augmentation therapy; however, these early findings must be supported by additional investigation in large-scale, placebo-controlled studies. This article reviews past and current research being done in this novel area of psychopharmacology.

show abstract

Gabapentin Augmentation for Fluoxetine-Treated Patients With Obsessive-Compulsive Disorder

Cited by 45 publications

References 0 publications

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study

Cancer pain and anxiety

Anticonvulsants in anxiety disorders

Contact Info

Product

Resources

About