GABAergic inhibition and modifications of taste responses in the cortical taste area in rats

Ogawa, Hisashi; Hasegawa, Kayoko; Otawa, Satoshi; Ikeda, Isamu

doi:10.1016/s0168-0102(98)00071-6

Cited by 26 publications

(14 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent simulations suggest explicit mechanisms of between-neuron coupling to explain such a process in olfaction (Bazhenov et al, 2001). The current results are also consistent with research suggesting that the taste specificity of neural responses is partially determined by interconnections among neurons (Ogawa et al, 1998;Smith and Li, 1998).…”

Section: Gustatory Processing Via Coherent Rate Changes In Taste-specsupporting

confidence: 88%

Taste-Specific Neuronal Ensembles in the Gustatory Cortex of Awake Rats

Katz,

Simon,

Nicolelis

2002

J. Neurosci.

View full text Add to dashboard Cite

In gustatory cortex, single-neuron activity reflects the multimodal processing of taste stimuli. Little is known, however, about the interactions between gustatory cortical (GC) neurons during tastant processing. Here, these interactions were characterized. It was found that 36% (85 of 237) of neuron pairs, including many (61%) in which one or both single units were not taste specific, produced significant cross-correlations (CCs) to a subset of tastants across a hundreds of milliseconds timescale. Significant CCs arose from the coupling between the firing rates of neurons as those rates changed through time. Such coupling significantly increased the amount of tastant-specific information contained in ensembles. These data suggest that taste-specific GC assemblies may transiently form and coevolve on a behaviorally appropriate timescale, contributing to rats' ability to discriminate tastants.

show abstract

Section: Gustatory Processing Via Coherent Rate Changes In Taste-specsupporting

confidence: 88%

Taste-Specific Neuronal Ensembles in the Gustatory Cortex of Awake Rats

Katz,

Simon,

Nicolelis

2002

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Indeed, there are no reports consistent with direct inhibitory projections from BLA. That inhibition intrinsic to GC (Yamamoto et al, 2010) can play an active role in sculpting gustatory responses has been shown in recordings before and after local pharmacological block of GABAergic transmission (Ogawa et al, 1998). Whether inhibition results from direct activation of feedforward inhibitory circuits in GC, as in the case of dopaminergic inputs (Ohara et al, 2003) or from recurrent activation of feedback interneurons by pyramidal cells is not known.…”

Section: Discussionmentioning

confidence: 96%

Amygdala Stimulation Evokes Time-Varying Synaptic Responses in the Gustatory Cortex of Anesthetized Rats

Stone

Maffei

Fontanini

2011

Front. Integr. Neurosci.

View full text Add to dashboard Cite

Gustatory stimuli are characterized by a specific hedonic value; they are either palatable or aversive. Hedonic value, along with other psychological dimensions of tastes, is coded in the time-course of gustatory cortex (GC) neural responses and appears to emerge via top-down modulation by the basolateral amygdala (BLA). While the importance of BLA in modulating gustatory cortical function has been well established, the nature of its input onto GC neurons is largely unknown. Somewhat conflicting results from extracellular recordings point to either excitatory or inhibitory effects. Here, we directly test the hypothesis that BLA can evoke time-varying – excitatory and inhibitory – synaptic responses in GC using in vivo intracellular recording techniques in urethane anesthetized rats. Electrical stimulation of BLA evoked a post-synaptic potential (PSP) in GC neurons that resulted from a combination of short and long latency components: an initial monosynaptic, glutamatergic potential followed by a multisynaptic, GABAergic hyperpolarization. As predicted by the dynamic nature of amygdala evoked potentials, trains of five BLA stimuli at rates that mimic physiological firing rates (5–40 Hz) evoke a combination of excitation and inhibition in GC cells. The magnitude of the different components varies depending on the frequency of stimulation, with summation of excitatory and inhibitory inputs reaching its maximum at higher frequencies. These experiments provide the first description of BLA synaptic inputs to GC and reveal that amygdalar afferents can modulate gustatory cortical network activity and its processing of sensory information via time-varying synaptic dynamics.

show abstract

“…When depolarized with KCl, these tissue samples released labeled acetylcholine, GABA, and glutamate, but not dopamine (Lopez-Garcia et al, 1990). Later studies showed that acetylcholine and GABA applied iontophoretically in gustatory cortex modulated tasteevoked neural activity (Ogawa et al, 1998;Hasegawa and Ogawa, 2007).…”

Section: Cortexmentioning

confidence: 99%