GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats

Rao, T V; Kokare, Dadasaheb M.; Sarkar, Sumit; Khisti, Rahul T.; Chopde, Chandrabhan T.; Subhedar, Nishikant K.

doi:10.1016/j.pbb.2003.08.016

Cited by 52 publications

(22 citation statements)

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“…Nonetheless, it remains possible that the ICV α-MSH treatment reduced the passive responses by some means other than its anti-inflammatory activity. α-MSH is an endogenous peptide that plays a role in appetite, anxiety, and other motivated responses (Gonzalez, Vaziri, & Wilson, 1996;Rao, Kokare, Sarkar, Khisti, Chopde, & Subhedar, 2003). While what is known about these other actions of α-MSH are not easily reconciled with the behavioral effects we observed, we cannot rule out an influence of our ICV infusion of α-MSH on motivational systems independent of inflammatory action.…”

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confidence: 71%

“…Second, the vocalizing of guinea pig pups during isolation procedures is considered to reflect an anxiety-like state (Borsini, Podhorna, & Marazziti, 2002). Since α-MSH has been found to produce anxiogenic effects in some species (Panksepp & Abbott, 1990;Rao et al, 2003) there would be reason to expect α-MSH would increase vocalizing. It may be worth noting in this regard that the subjective impression of the primary observer during Experiment 1 was that α-MSH had a calming effect on the pups.…”

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation

Hennessy

Schiml-Webb

Miller

et al. 2007

Psychoneuroendocrinology

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A previous study found that intracerebroventricular (ICV) infusion of 25 μg of α-MSH reduced the passive responses (crouched stance, eye-closing, piloerection) of guinea pig pups during a 3-hr isolation in a novel environment. Because α-MSH has broad anti-inflammatory properties, the results suggested that proinflammatory factors play a role in mediating the behavior of isolated infants. The present study further investigated this possibility. In Experiment 1, injection of lipopolysacchride (LPS) increased the number of 60-s intervals in which pups expressed the same three responses during a 1-hr test, and ICV infusion of α-MSH significantly reduced the effect of LPS on crouching and piloerection. In Experiment 2, the prostaglandin synthesis inhibitor indomethacin (10mg/kg) reduced the number of 60-s intervals in which pups exhibited both crouching and the full suite of passive responses during a 3-hr isolation in a novel environment. Together these results provide further support for the hypothesis that the passive behaviors exhibited during prolonged isolation are "stressinduced sickness behaviors" mediated by proinflammatory factors. Keywords sickness behaviors; acute phase response; inflammation; maternal separation; isolation; guinea pig Stimulation of the innate immune system results in a systemic physiological and behavioral reaction known as the acute phase response or sickness (Baumann & Gauldie, 1994). Components of the acute phase response include: fever, shifts in the synthesis of liver proteins, activation of the hypothalamic-pituitary-adrenal system, sleepiness, assumption of a curled or hunched posture, piloerection, shivering, and reductions in various activities. Though the behavioral components may appear to be simply the result of debilitation, they are adaptive responses that contribute to recuperation by, for instance, supporting the production of fever (e.g., hunched posture, piloerection, shivering), which in turn, can inhibit further proliferation of pathogens (Aubert, 1999;Hart, 1988). The acute phase response is triggered by the release of proinflammatory cytokines (e.g., IL-1, IL-6, TNF-α) in the periphery and CNS (Dantzer, 2004).Address correspondence to: Michael B. Hennessy, PhD, Department of Psychology, 335 Fawcett Hall, Wright State University, 3640 Col Glenn Hwy, Dayton, OH 45435, 937.775.2943 (voice), 937.775.3347 (FAX), michael.hennessy@wright.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. In the last decade, it has become apparent that aspects of the acute phase response, including sickness behaviors, do not occur solely ...

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confidence: 71%

Section: Discussionmentioning

confidence: 99%

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Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation

Hennessy

Schiml-Webb

Miller

et al. 2007

Psychoneuroendocrinology

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“…Supporting this contention, ICV administration of α-MSH (a melanocortin agonist) enhanced the expression of the gene encoding NUCB2 in the PVN (Oh et al 2006), whereas administration of the melanocortin receptor antagonist, SHU9119, attenuated nesfatin-1-induced satiety (Oh et al 2006). The melanocortin system appears to be involved in the mediation of anxiety-related behaviors, as administration of α-MSH reduced time spent on the open arms of the EPM as well as the number of licks in the Vogel test (Rao et al 2003;Chaki et al 2003). Moreover, pretreatment with SHU9119 dose-dependently attenuated stressor-induced anxiogenic behaviors (measured on the EPM) (Liu et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Nesfatin-1 increases anxiety- and fear-related behaviors in the rat

et al. 2008

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“…The number of entries into the open arms, the time spent in open arms as well as the number of closed-arm entries were recorded for 5 min by a trained observer blind to the treatment protocol. It was indicated in numerous analytical studies that the closed-arm entries may be a more reliable index of general activity levels than the total arm entries (Pellow et al 1985;Lister 1987;Dawson et al 1995;Rodgers and Johnson 1995;Rao et al 2003). An entry was registered only when all the four paws of the animal were put on the arm.…”

Section: Elevated Plus Maze Testmentioning

confidence: 99%

Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats

et al. 2005

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GABAergic agents prevent alpha-melanocyte stimulating hormone induced anxiety and anorexia in rats

Cited by 52 publications

References 47 publications

Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation

Anti-inflammatory agents attenuate the passive responses of guinea pig pups: Evidence for stress-induced sickness behavior during maternal separation

Nesfatin-1 increases anxiety- and fear-related behaviors in the rat

Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats

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