Nesfatin-1 increases anxiety- and fear-related behaviors in the rat

Merali, Zul; Cayer, Christian; Kent, Pamela; Anisman, Hymie

doi:10.1007/s00213-008-1252-2

Cited by 140 publications

(92 citation statements)

References 58 publications

(64 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Central injection of CART and nesfatin/NUCB2 into male rodents increases anxiety (Koylu et al, 2006;Merali et al, 2008). This is in line with our observation of increased CART and nesfatin/NUCB2 mRNA expressions in depressed suicide victims.…”

Section: Discussionsupporting

confidence: 91%

“…The results extend prior observations on the possible involvement of CART and nesfatin/NUCB2 in MDD in humans (Ari et al, 2011;Miraglia del Giudice et al, 2006) and in anxiety-and depressive-like behaviour in rodents (Dandekar et al, 2008;Garcia-Galiano et al, 2010;Merali et al, 2008;Wiehager et al, 2009) in a number of ways. Firstly, we showed that CART and nesfatin-1 were present and colocalized in EWcp neurons.…”

Section: Discussionsupporting

confidence: 88%

“…NUCB2 is a precursor protein that is cleaved by prohormone convertases into multiple fragments with largely unknown biological functions (Foo et al, 2008;Oh et al, 2006). Upon intracerebroventricular administration, nesfatin-1 exerts, besides a strong anorexigenic action, anxiogenic effects as well (Garcia-Galiano et al, 2010;Merali et al, 2008). Interestingly, Ari et al have recently demonstrated higher plasma nesfatin-1 levels in patients with MDD that is positively correlating with the Hamilton Depression Rating scale (Ari et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls

Bloem

Morava

et al. 2012

Neuropharmacology

View full text Add to dashboard Cite

a b s t r a c tAn intriguing novel pathophysiological insight into mood disorders is the notion that one's metabolic status influences mood. In rodents, cocaine-and amphetamine-regulated transcript (CART) and nesfatin-1/NUCB2 have not only been implicated in metabolism, but in the pathobiology of anxiety and depressive-like behaviour, however they have not previously been investigated in depressed subjects. Both peptides are highly expressed in centrally projecting neurons in the Edinger-Westphal nucleus (EWcp) in the midbrain. The EWcp has been implicated in stress adaptation and stress-related mood disorders like major depressive disorder in a sex-specific manner. This is intriguing, given the fact that females have higher prevalence of mood disorders. Here, we hypothesized that the expression of CART and nesfatin-1 in EWcp would exhibit a sex-specific difference between depressed suicide victims vs. controls. We found that CART and nesfatin/NUCB2 colocalized in the human EWcp, and that CART mRNA content was much higher in both male (Â3.8) and female (Â5.9) drug-free suicide victims than in controls (persons who died without any diagnosed neurodegenerative or psychiatric disorder). Similarly, NUCB2 mRNA content was also higher (Â1.8) in male suicides, whereas in female suicide victims, these contents were Â2.7 lower compared to controls. These observations are the first to show changes in the dynamics of CART and nesfatin/NUCB2 expressions in the midbrain of drug-free depressed suicide victims vs. controls.This article is part of a Special Issue entitled 'Anxiety and Depression'.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls

Bloem

Morava

et al. 2012

Neuropharmacology

View full text Add to dashboard Cite

show abstract

“…Most of the authors working on rats and using icv injections investigating different aspects of nesfatin-1's actions have also found the 5 --20 pmol dose range effective, higher doses only caused earlier timing of the effect, and/or enhanced the tendencies observed with lower dose. 5,22,23 We also found the 25 pmol dose as an adequate one, increasing the dose to 100 pmol did not lead to any substantially new observations. Long-lasting effects and interference with the diurnal rhythm are not exclusive among the peptides regulating energy balance.…”

Section: Discussionmentioning

confidence: 53%

Nesfatin-1 exerts long-term effect on food intake and body temperature

Könczöl

Pintér²,

Ferenczi

et al. 2012

Int J Obes

View full text Add to dashboard Cite

OBJECTIVE:To determine whether the anorexigenic peptide, nesfatin-1 affects energy expenditure, and to follow the time course of its effects. DESIGN: Food intake duration, core body temperature, locomotor activity and heart rate of rats were measured by telemetry for 48 h after a single intracerebroventricular injection of 25 or 100 pmol nesfatin-1 applied in the dark or the light phase of the day. Body weight, food and water intake changes were measured daily. Furthermore, cold-responsive nesfatin-1/NUCB2 neurons were mapped in the brain. RESULTS: Nesfatin-1 reduced duration of nocturnal food intake for 2 days independently of circadian time injected, and raised body temperature immediately, or with little delay depending on the dose and circadian time applied. The body temperature remained higher during the next light phases of the 48 h observation period, and the circadian curve of temperature flattened. After light phase application, the heart rate was elevated transiently. Locomotion did not change. Daily food and water intake, as well as body weight measurements point to a potential decrease in all parameters on the first day and some degree of compensation on the second day. Cold-activated (Fos positive) nesfatin-1/NUCB2 neurones have been revealed in several brain nuclei involved in cold adaptation. Nesfatin-1 co-localised with prepro-thyrotropin-releasing hormone in cold responsive neurones of the hypothalamic paraventricular nucleus, and in neurones of the nucleus raphe pallidus and obscurus that are premotor neurones regulating brown adipose tissue thermogenesis and skin blood flow. CONCLUSION: Nesfatin-1 has a remarkably prolonged effect on food intake and body temperature. Time course of nesfatin-1's effects may be varied depending on the time applied. Many of the nesfatin-1/NUCB2 neurones are cold sensitive, and are positioned in key centres of thermoregulation. Nesfatin-1 regulates energy expenditure a far more potent way than it was recognised before making it a preferable candidate anti-obesity drug.

show abstract

“…It stimulates autonomic nervous system activity, increases blood pressure (53), and has been associated with a range of brain functions, including the regulation of feeding. Nucleobindin induces fear and anxiety in rats (54). Nesfatin-1 also elevates the intracellular concentration of Ca 2ϩ in mouse neurons and causes calcium signaling via calcium influx through Ca V 2.2 calcium channels (55).…”

Section: Resultsmentioning

confidence: 99%

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Wong

Morgenstern

Mofiz

et al. 2012

Molecular & Cellular Proteomics

View full text Add to dashboard Cite

Nesfatin-1 increases anxiety- and fear-related behaviors in the rat

Abstract: These findings suggest that in addition to its role as a satiety peptide, nesfatin-1 may also be involved in the mediation of anxiety- and/or fear-related responses.

Cited by 140 publications

References 58 publications

Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls

Sex-specific differences in the dynamics of cocaine- and amphetamine-regulated transcript and nesfatin-1 expressions in the midbrain of depressed suicide victims vs. controls

Nesfatin-1 exerts long-term effect on food intake and body temperature

Proteomics and Deep Sequencing Comparison of Seasonally Active Venom Glands in the Platypus Reveals Novel Venom Peptides and Distinct Expression Profiles

Contact Info

Product

Resources

About